DEPRESSION - MAJOR DEPRESSIVE DISORDER

This study tests whether a nurse-led program can help women aged 45-64 in Hong Kong better manage their health and use medical resources wisely. Over 1,700 participants will either receive personalized nurse guidance or general health advice. The goal is to improve health confide…

This study tests whether a robot that can be personalized by older adults helps reduce loneliness and depression better than a standard robot or usual care. About 90 people aged 65 and older living in a community center will interact with the robot for 20 minutes twice a week ove…

This study tests whether a smartphone app called MENTINA can help people with current or past depression better manage their symptoms. About 660 adults from Denmark, Germany, and Spain will use the app for 12 months. The goal is to see if the app's feedback reduces depressive sym…

This study tests a device that uses mild electrical currents to stimulate the brain in people with major depression. The device adjusts the stimulation based on the person's brain activity. The goal is to see if the device works correctly and if it can help reduce depression symp…

This study tests whether a non-invasive brain stimulation technique called accelerated theta burst stimulation (aTBS) can safely reduce symptoms of depression in people with autism spectrum disorder (ASD). Researchers will compare the active treatment to a sham (placebo) procedur…

This study tests whether Compound Ciwujia Granules, a traditional Chinese herbal medicine, can help reduce depression symptoms in people with a specific syndrome (heart-spleen deficiency). About 60 adults with major depressive disorder will take either the granules or a placebo t…

This study tests whether a 4-month anti-inflammatory diet can reduce symptoms of anxiety and depression in 60 adults. Participants will be assigned to either the special diet or their usual eating habits. Researchers will also use AI to analyze speech and facial expressions to se…

This study looks at whether data from smartphones and Fitbit devices can help predict when a depressive episode might come back. Over 12 months, 540 people with mood disorders or at high risk will wear a Fitbit, use a mood app, and have five check-ins. The goal is to build AI mod…

This study looks at whether emphasizing certain words in a mental health questionnaire changes how people respond. Researchers will ask 200 adults with depression or anxiety to fill out the same survey twice in one day, with different instructions. The goal is to understand if th…

This study is testing a type of magnetic brain stimulation called theta-burst rTMS in 54 adults with depression that hasn't improved with other treatments. The main goal is to see if brain scans and electrical activity measurements can predict who will get better. Researchers wil…

This study looks at how esketamine nasal spray helps reduce suicidal thoughts in people with severe depression. Researchers want to know if symptoms like loss of pleasure (anhedonia) and emotional pain can predict who benefits most. The study analyzes data from 456 patients who t…

This study explores whether artificial intelligence (AI) can analyze a person's speech to help diagnose mental health conditions like depression, anxiety, ADHD, and autism. Researchers will collect speech samples from 500 people aged 16-60 who are being evaluated for mental healt…

This study looks at whether viral infections can trigger or worsen mental health conditions like anxiety, depression, bipolar disorder, and schizophrenia. Researchers will analyze health records from about 100,000 people in Israel to compare those with many past infections to tho…

This study looks at whether Black, Indigenous, and People of Color (BIPOC) face more barriers to starting or sticking with antidepressants after a one-time psychiatric consultation. Researchers will survey 60 adults diagnosed with depression to see if race affects medication reco…

This study looks at blood samples from 46 people with treatment-resistant depression who took psilocybin in a previous trial. Researchers want to see if inflammation levels in the blood before and after treatment are linked to how well the depression improves. The goal is to bett…

This study tests whether adding stigma-reduction counseling to standard depression treatment helps adults living with HIV in Malawi. Researchers will enroll 200 people and measure if the approach is acceptable, feasible, and improves depression symptoms and HIV care engagement. T…

This study was designed to see if a drug called LY-2940094 could protect healthy people from developing depression or anxiety after stress. Researchers planned to measure brain responses to rewards and fear using tasks and questionnaires. However, the study was withdrawn before a…