CHRONIC KIDNEY DISEASES

This study looks at whether mindfulness meditation can improve nerve function in people with chronic kidney disease (CKD). It also tests if a gentle nerve stimulation device can boost the benefits. The study involves 150 adults with moderate CKD and measures changes in nerve acti…

This study tests whether a drug called sodium zirconium cyclosilicate (SZC) can safely lower potassium levels in elderly patients with heart failure and chronic kidney disease. By controlling potassium, doctors hope to give these patients higher, more effective doses of heart-pro…

This Phase 3 trial is testing different treatments to slow the worsening of chronic kidney disease (CKD) and reduce the number of people who develop kidney failure. About 1,000 adults with CKD will receive standard care plus one or more experimental agents. The goal is to find th…

This study tests a program that combines home blood pressure monitors, a mobile app, community health workers, and pharmacist support to help adults with uncontrolled high blood pressure plus diabetes or kidney disease. About 425 participants from 16 clinics will either get usual…

This study tests whether it is possible to transplant a kidney and a bladder together in people who have both kidney failure and bladder problems. Up to 30 participants aged 1 to 60 will receive the combined transplant and be followed for several years. The goal is to see if the …

This study tests a special wrap called SelfWrap placed around blood vessels during fistula creation surgery for dialysis. The goal is to help the fistula mature faster and work without needing extra procedures. About 600 adults with chronic kidney disease will take part, and they…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease better control their blood sugar. Participants will use the system for 8 weeks and then switch to their usual care for another 8 weeks, …

This study looks at how long people with advanced chronic kidney disease should take two blood thinners (aspirin plus clopidogrel or prasugrel) after getting a heart stent. About 900 adults with severe kidney disease will be randomly assigned to either a short or long course of d…

This study tests if a device called the Gemini System can safely lower blood pressure by disrupting certain nerves in the kidney and liver. It includes 175 adults with uncontrolled high blood pressure, with or without other health risks like heart or kidney disease. The main goal…

This study tests a pharmacy-led program to help low-income patients with chronic conditions like diabetes and heart disease take their medications after leaving the hospital. The program provides free medications, bedside delivery, and health coaches to help with follow-up care. …

This study tests a program where a team of doctors and pharmacists work together to safely reduce or stop medications that may be unnecessary or harmful for people with chronic kidney disease. About 424 patients in Qatar will take part. The goal is to lower the number of risky dr…

This early-phase study tests whether stem cells from amniotic fluid can help heal painful skin wounds (calciphylaxis) in people with chronic kidney disease. Nine participants will receive the stem cell treatment, and researchers will measure wound healing and pain levels. The goa…

This early-phase study tests whether a stem cell infusion from the same donor can allow kidney transplant recipients to safely stop their daily anti-rejection medications. Ten adults with a stable, well-functioning kidney from a matched living donor will receive a conditioning tr…

This study tests if giving two medicines—tranexamic acid and desmopressin—before surgery can reduce bleeding in people with kidney problems. About 100 adults with chronic kidney disease or acute kidney injury who need noncardiac surgery will take part. The goal is to see if these…

This study tests whether colchicine, an anti-inflammatory drug, can improve heart function in people with chronic kidney disease. Researchers will measure changes in heart strain and size using ultrasound. The trial enrolls 20 adults aged 21-80 with moderate to severe kidney dise…

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation therapy, a different antidepressant (bupropion), or a placebo, with the option to…

This study tests whether adults with sudden illnesses like infections, heart failure, or asthma can be safely treated at home instead of in a hospital. About 3,000 participants will receive hospital-level care in their own homes, with a caregiver present for the first 24 hours. T…

This study tests whether bone marrow stem cells are safe for people with chronic kidney disease, including those who have had a kidney transplant. About 75 adults will receive stem cells through a vein or directly into the kidney arteries. The goal is to monitor side effects, not…

This study tests a streamlined version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. The goal is to see if a faster approach works just as well as the standard method. About 130 adults with uncontrolle…

This study tests whether patiromer, a drug that lowers potassium, allows people with chronic kidney disease to safely increase their dose of a common blood pressure medication (irbesartan). The goal is to see if this reduces protein in the urine and lowers blood pressure, which c…

This study looks at whether using a home blood pressure monitor plus a dedicated case manager can help people with chronic kidney disease and high blood pressure living in remote areas better control their blood pressure. About 146 participants will either use the monitor with th…

This study tests an experimental cell therapy called REACT (rilparencel) in 685 adults with type 2 diabetes and chronic kidney disease. The goal is to see if up to two injections can slow the loss of kidney function compared to a sham procedure. Participants will be followed for …

This study tests whether gentle shockwave therapy to the kidneys can help lower blood pressure and improve kidney function in people with chronic kidney disease and high blood pressure. 30 adults will receive either real or sham treatments over three weeks. The goal is to see if …

This study tests a new ultrasound technique called shear wave elastography to help doctors quickly tell whether a patient's kidney problem is new (acute) or long-term (chronic). The goal is to make diagnosis faster and safer in the emergency room, avoiding the need for contrast d…

This study is testing a new imaging technique called dynamic full-field optical coherence tomography (OCT) to analyze kidney biopsy samples. The goal is to see if this method can quickly and accurately identify signs of acute kidney injury or chronic kidney disease, compared to t…

This study tests whether a 12-week physical activity program helps teens with chronic kidney disease (CKD) become more active. About 100 teens aged 13-18 with CKD stages II-V (not on dialysis or with a transplant) will wear a Fitbit to track their activity. The goal is to see if …

This study looks at whether a simple home-based walking program can help improve memory, thinking speed, and brain structure in older adults who have both chronic kidney disease and mild cognitive impairment. About 144 participants aged 55 and older will walk regularly for 6 mont…

This study tests a small device that gently stimulates a nerve in the ear to see if it can safely improve nerve-related symptoms in people with chronic kidney disease. Thirty adults with stage 3-5 kidney disease will use the device for 15 minutes a day over two weeks. The main go…

This study tests whether a smartphone app can help people with kidney problems control body swelling by guiding daily adjustments of their water pills (diuretics). Thirty participants will use the app for 90 days, entering their weight and blood pressure daily and following the a…

This study tests whether a 12-week high-velocity resistance training program is safe and doable for 30 older adults with advanced chronic kidney disease. Participants will either do the strength exercises or attend weekly healthy lifestyle group sessions. The goal is to see if th…

This study tests if a medicine called difelikefalin is safe for teenagers aged 12 to 17 who have severe itching due to kidney disease and are on dialysis. All 18 participants will receive the medicine during their regular dialysis visits for up to 12 weeks. The goal is to see if …

This study is collecting blood and urine samples from 5,000 adults with kidney disease or at risk for it, including transplant recipients. Researchers will analyze genes, proteins, and immune cells to find patterns that predict disease progression, complications, or response to t…

This study looks at how social needs like food, housing, or transportation affect self-care and health in African American adults with diabetic kidney disease. Researchers will talk with 330 participants to understand these challenges and design a program that fits their culture.…

This study looks at how the eyes, brain, and kidneys interact in adults with chronic kidney disease (CKD). Researchers will use non-invasive MRI scans and eye imaging to see if changes in the brain and retina are linked to thinking problems and kidney function. About 1,500 partic…

This study is collecting kidney tissue samples from 1,000 people with acute kidney injury or chronic kidney disease, including those with diabetes. Researchers will use advanced technology to analyze the tissue and identify different disease subtypes. The goal is to better unders…

This study looks at a rare but life-threatening condition called calciphylaxis, where small blood vessels in the skin harden. It happens mostly in people with advanced kidney disease, but doctors don't know exactly why or how to treat it effectively. Researchers will compare 860 …

This study looks at how chronic kidney disease affects the immune system, specifically T-cells, which help fight infections. Researchers will analyze blood samples from 100 patients to understand immune weakness. They will also test a new lab technique to engineer T-cells that mi…

This study looks at why people with chronic kidney disease (CKD) often lose muscle mass and strength, a condition called sarcopenia. Researchers will follow 1,000 adults with CKD to find risk factors for sarcopenia and see how it relates to worse health outcomes like disease prog…

This study will screen 3,000 adults at a large hospital to find out how many have chronic kidney disease, especially those who don't know it yet. Participants are over 50, or over 18 with conditions like diabetes or high blood pressure. The goal is to measure how common the disea…

This study looks at 300 people with type 2 diabetes who have high levels of protein in their urine, a sign of kidney trouble. Researchers will take small kidney samples (biopsies) and analyze blood, urine, and genetic data to find patterns that help diagnose diabetic kidney disea…

This study looks at easier methods to measure how well the kidneys can handle extra work (kidney reserve). Researchers will give a protein drink and check changes in kidney function. The study includes 44 adults with sickle cell disease or who have donated a kidney. No treatment …

This study looks at how the sedative remimazolam behaves in 30 adults receiving a kidney transplant. Researchers will measure drug levels in the blood and check how deeply patients are sedated during anesthesia. The goal is to understand the drug's safety and effects in this spec…

This study looks at whether a single dose of equol, a substance made from soy, can improve blood vessel function in postmenopausal women. It includes women with and without chronic kidney disease (CKD). Researchers will measure changes in artery health over a few hours after taki…

This study looks at how blood pressure and artery stiffness change between day and night in 120 people at increased risk for heart disease, including those with kidney issues. Researchers want to understand who lacks the healthy nighttime blood pressure drop and whether taking me…

This study looks at how dapagliflozin, a drug used for diabetes, affects heart and lung function in people with chronic kidney disease and early signs of heart failure. Researchers will measure heart strain, oxygen use during exercise, and blood markers. About 60 adults with mode…

This study looks at how common sleep apnea is in people with chronic kidney disease and whether it makes their kidney function worse over time. Researchers will follow 356 adults with moderate kidney disease for several years, tracking their health and any heart or kidney problem…

This study looks at whether it's possible to run a larger trial of a drug called empagliflozin (a type of SGLT2 inhibitor) in 40 children and teens with chronic kidney disease. Participants are randomly assigned to take the drug or continue usual care for 3 months. The goal is to…

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease after they leave the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms and questions fo…

This study follows 300 babies born early (preterm) and at full term to understand how early birth affects kidney and heart health later in life. Researchers use ultrasound and blood/urine tests to spot early warning signs of kidney disease and high blood pressure. The goal is to …

This study looks at whether doing handgrip exercises at home for 8 weeks can help lower blood pressure in people with chronic kidney disease (stages 3 and 4). About 50 adults aged 45-85 who do not exercise regularly will take part. Researchers will measure blood pressure, artery …

This study follows 200 adults with advanced chronic kidney disease as they start dialysis at home or in a center. Researchers will track changes in quality of life, frailty, fatigue, and mood every 3 months for a year. The goal is to see if home dialysis helps patients stay healt…