CHRONIC KIDNEY DISEASES

This study looked at whether adults with acute illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. 160 rural patients were randomly assigned to receive hospital-level care at home or usual hospital care. The goal was to see if…

This study tested whether a low-dose blood thinner called rivaroxaban could lower the risk of major heart problems (like heart attack or stroke) in people with advanced chronic kidney disease or kidney failure on dialysis. About 1,753 participants were randomly assigned to receiv…

This study tested a drug called TOUR006 in 143 people with chronic kidney disease and high levels of a blood marker for inflammation (hs-CRP). The goal was to see if monthly or quarterly injections could safely lower inflammation. The study is complete, and results will show if t…

This study tested whether an educational worksheet plus health coaching could help people with chronic kidney disease and high blood pressure lower their blood pressure. 320 adults with moderate to severe kidney disease took part. The goal was to see if this approach improves blo…

This study looked at whether community health workers (CHWs) can improve health outcomes for people with chronic conditions like diabetes, high blood pressure, and obesity. Over 10 months, 202 low-income adults from specific zip codes received either CHW support plus standard car…

This study tested a new treatment called REACT (rilparencel) for people with type 1 or type 2 diabetes who also have chronic kidney disease. The treatment uses a person's own kidney cells to try to slow down kidney damage. 53 adults aged 30 to 80 took part, and the study looked a…

This study tested a drug called Ziltivekimab in 264 adults with advanced chronic kidney disease and signs of inflammation. The goal was to find the right dose to lower inflammation and potentially reduce heart risks. Participants received monthly injections of either a placebo or…

This study tested a new device that creates a connection between an artery and vein using a needle instead of surgery, making dialysis access easier. It involved 24 adults with kidney failure who needed dialysis. The goal was to see if the device worked safely and could offer mor…

This study tested two programs to help people with chronic kidney disease get kidney transplants sooner and more equitably. One program identifies patients who may need a transplant early, and the other provides extra support from social workers and coordinators. Over 1,100 adult…

This study checked the safety of a new dialysis filter called ELISIO™-HX in 22 adults with kidney failure who were already on dialysis. The main goal was to make sure the filter did not lower blood protein (albumin) levels, while also improving removal of certain waste products. …

This study tested a digital program called DDEP that helps people with chronic kidney disease and their care partners make healthy lifestyle changes. 208 participants either received the program plus usual care or usual care alone for six months. The goal was to see if the progra…

This pilot study tested whether people with type 2 diabetes and early kidney disease can take part in a clinical trial from home. Twelve participants collected their own urine, blood, and blood pressure readings remotely. They took empagliflozin first, and based on their response…

This study tested whether dapagliflozin, a diabetes drug, can reduce protein in the urine (proteinuria) and protect kidney function in 55 adults who had a kidney transplant and have chronic kidney disease. Participants took the drug as prescribed and were followed for 6 months. T…

This study tested an experimental drug called KBP-5074 in 162 people with moderate-to-severe chronic kidney disease whose high blood pressure was not well controlled. The goal was to see if the drug could safely lower blood pressure and reduce kidney damage. Participants were ran…

This study tested a new system (everlinQ) to create a connection between an artery and vein in the arm for dialysis. 32 adults with kidney failure who needed dialysis took part. The goal was to see if the connection matured properly and safely, so patients could receive dialysis …

This small study tested a talking therapy program to help reduce tiredness in people with chronic kidney disease. Five adults with moderate-to-severe kidney disease took part in remote sessions. The goal was to see if the program was acceptable and could be tested in a larger fut…

This early-stage study tested a new drug called DISC-0974 in 55 adults with chronic kidney disease (not on dialysis) and anemia. The main goal was to check safety and how the drug moves through the body. Researchers also looked at changes in iron and blood levels. The study is no…

This study looked at whether adding empagliflozin (a diabetes drug) to standard water pills helps people with acute heart failure and moderate-to-severe kidney disease urinate out more excess fluid. 25 adults participated, and researchers measured urine output after combining the…

This study looked back at medical records of 490 patients with liver cirrhosis who also had signs of a liver-kidney syndrome. Researchers compared how well patients with and without chronic kidney disease responded to standard treatment with terlipressin and albumin. The goal was…

This study used advanced MRI scans to look at the hearts of 276 people with chronic kidney disease, including those on dialysis. The goal was to understand why heart problems are so common in kidney patients and to find better ways to predict and manage these risks. Researchers f…

This study tested a program to improve how older adults (65+) with advanced kidney disease talk with their doctors about dialysis. The program trained doctors in communication and coached patients to share their values and questions. The goal was to see if the program was feasibl…

This study looked at how dapagliflozin, a kidney-protecting drug, changes the gut bacteria in people with chronic kidney disease who do not have diabetes. Researchers measured gut bacteria diversity and related toxins in the blood before and after 12 weeks of treatment. The goal …

This study aimed to create a tool that helps doctors decide which patients with severe acute kidney injury (AKI) would benefit from seeing a kidney specialist (nephrologist) after leaving the hospital. Researchers looked at 319 patients who needed dialysis for severe AKI to find …

This study looked at whether special ultrasound tests can predict if a surgically created blood vessel connection (called an arteriovenous fistula or AVF) will work well for dialysis in people with end-stage kidney disease. Researchers measured artery stiffness and blood flow in …

This study looked at past patient records to see if a computer program could predict who would need to be readmitted to the hospital within 30 days of leaving. Researchers used data from 372 patients treated at home through a hospital program. The goal was to improve care, not to…

This study looked at how certain gene variants (APOL1) are linked to advanced chronic kidney disease in Afro-Caribbean adults. Researchers analyzed blood samples from 88 participants in Guadeloupe to understand the role of these genes. The goal was to gather knowledge, not to tes…

This study tested whether helping low-income African Americans with diabetic kidney disease meet their basic needs (like food, housing, and utilities) could improve their health. Fifty participants received support to address these challenges. The goal was to see if this approach…

This study looked at how sex hormones, like estrogen, affect blood vessel function in women with chronic kidney disease (CKD). Researchers compared pre- and post-menopausal women with CKD to healthy women of the same age. The goal was to understand why women with CKD have higher …

This study tested whether an electronic alert in the medical record system could prompt doctors to order a urine test that checks for early kidney damage in people with type 2 diabetes. About 400 adults who hadn't had this test in the past year took part. The goal was to see if t…

This study tested a computer system that alerts doctors when patients might have chronic kidney disease (CKD) and need further tests or specialist referral. The trial involved 65 primary care centers in Stockholm and used existing health records to measure the system's impact. Th…

This study tested whether community health workers and trauma-informed care training for doctors can improve quality of life for Black and Hispanic patients with advanced chronic kidney disease. 153 patients from high-poverty areas in Philadelphia took part. The goal was to see i…

This study tested whether sending digital letters to patients with chronic kidney disease and their general practitioners could increase use of recommended medications. Over 28,000 adults in Denmark took part. The letters reminded them about updated treatment guidelines. The goal…

This study analyzed health records from nearly 1 million Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers looked at changes in doctor visits, tests, and treatments before and du…

This study looked at data from 526 patients treated at home through a hospital-at-home program. Researchers used a computer algorithm to try to predict if a patient would get worse during their stay. The goal was to see if machine learning could help doctors spot problems earlier…

This study tested whether 3D ultrasound can reliably measure the size of kidneys and kidney tumors, comparing it to standard CT or MRI scans. 53 adults with chronic kidney disease or kidney tumors participated. The goal was to see if this simpler, radiation-free method could be u…

This study tested a program called KidneyTIME that uses videos and text messages to teach kidney patients about getting a transplant from a living donor. Over 400 adults waiting for a kidney took part. The goal was to see if the program helped patients learn more and led to more …

This study tested whether using a more accurate blood pressure reading from the aorta (central BP) instead of the usual arm cuff helps manage hypertension in people with advanced chronic kidney disease. 116 participants were randomly assigned to either central or standard BP targ…

This study looked at how well primary care doctors referred patients with chronic kidney disease to kidney specialists. Researchers checked if referrals happened quickly enough and if patients were on the right treatment. The study involved 345 adults and used medical records fro…