BIPOLAR DISORDER

This study tested a special support program for veterans who have both bipolar disorder and substance use problems after they leave the hospital. Half of the 138 veterans received the new program, while the other half got extra safety check-ins. The goal was to see if the program…

This study tested whether a 4-week ketogenic diet (very low carb, high fat) could improve brain network stability and thinking skills in 71 adults with schizophrenia or bipolar disorder. The diet aims to provide an alternative brain fuel (ketones) that may bypass problems with gl…

This study looked at whether repeated ketamine infusions can help people with bipolar depression who did not get better with other treatments. 41 adults who already responded to an initial course of ketamine received up to 6 more infusions over 12 weeks. The goal was to see if th…

This study tested whether a smartphone app called Quit on the Go helps people with serious mental illness (like bipolar disorder or schizophrenia) quit smoking better than standard methods. 343 smokers who wanted to quit were enrolled. The app was designed specifically for their …

This study tested a therapy called BE-SMART-DR in 65 teens and young adults with bipolar disorder or major depression who had suicidal thoughts or past attempts. The therapy teaches self-guided strategies to regularize sleep and daily rhythms to reduce short-term suicide risk. Pa…

This study tested whether adding aripiprazole to lamotrigine helps people with bipolar I disorder avoid future manic or mixed episodes. Over 1,100 adults took part for up to a year. The goal was to see if the combination kept mood stable longer than lamotrigine alone.

This study tested a program called CARE to help people with bipolar disorder stick to their treatment after leaving prison. 18 adults participated to see if the program was practical and helpful. The goal was to improve mood stability and reduce symptoms.

This study tested a customized program to help 36 teens and young adults with bipolar disorder take their medication as prescribed. Many young people with bipolar disorder struggle with taking their meds, which can lead to relapse and higher suicide risk. The program aimed to imp…

This study tested a special program to help people with both bipolar disorder and substance use problems stick with their treatment after leaving the hospital. 178 adults took part, with half getting the new program and half getting extra safety check-ins. The goal was to see if …

This study tested a program called CARE to help people with bipolar disorder stay on their treatment after leaving prison. 34 adults took part to see if the program was practical and helpful. The goal was to improve mood stability and treatment adherence during the difficult tran…

This study tested a culturally adapted psychoeducation program (CaPE) for adults with bipolar disorder in Pakistan. 303 participants in remission were randomly assigned to receive either CaPE plus usual care or usual care alone. The goal was to see if CaPE could delay mood episod…

This study tested whether adding probiotics (beneficial bacteria) to standard bipolar depression treatments can reduce depressive symptoms. 141 adults with bipolar disorder took either probiotics or a placebo for 12 weeks. The goal was to see if probiotics improve mood and how th…

This study tested a new way to use magnetic brain stimulation (rTMS) to treat depression in 40 adolescents with bipolar disorder. The treatment targeted the back of the head, guided by brain scans, to see if it could improve mood. The goal was to find a safer, non-drug option for…

This study tested whether a non-invasive brain stimulation technique (transcranial electrical stimulation) could reduce mania symptoms in people with bipolar or schizoaffective disorder. Fourteen adults with mild-to-moderate mania received the stimulation targeting a brain area l…

This pilot study tested two simple, drug-free therapies—time-restricted eating and blue-blocking glasses—for people hospitalized with mania from bipolar disorder. The goal was to see if these approaches are feasible and safe, and whether they can help calm manic symptoms and rest…

This study tested a drug called BHV-7000 to see if it safely reduces manic symptoms in people with bipolar I disorder. 274 hospitalized adults took either the drug or a placebo for 21 days. The main goal was to measure changes in mania severity using a standard rating scale.

This study tested a program called Metacognitive Training (MCT) in 18 Taiwanese adults with schizophrenia, major depression, or bipolar disorder. Over four weeks, participants attended eight group sessions aimed at reducing unhelpful thinking patterns linked to symptoms like delu…

This study tested a special nursing program for 60 family caregivers of people with bipolar disorder. The program aimed to reduce their stress and help them feel more resilient and positive. Researchers measured changes in caregiver burden and emotional well-being 12 weeks after …

This study tested a noninvasive brain stimulation technique called transcranial random noise stimulation to see if it could reduce cravings in people with substance use disorder who also have other mental health conditions like ADHD, bipolar disorder, or schizophrenia. 225 adults…

This study tested whether repeated doses of intravenous ketamine can safely and effectively reduce depression in people with bipolar disorder who haven't responded to other treatments. 71 adults with bipolar I or II and current major depression received four ketamine infusions or…

This study looked at whether a type of talk therapy called Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) works for veterans who also have a serious mental illness like schizophrenia or bipolar disorder. 47 veterans took part to see if the therapy was helpful and practica…

This study tested a program called IPS-MA, which helps people with mood or anxiety disorders find and keep a job or return to school. 326 adults who were unable to work within three months took part. The program was added to their usual care to see if it helped them recover and r…

This study tested a 4-week virtual reality (VR) cognitive training program in 62 people with stable mood disorders (depression or bipolar) or psychosis spectrum disorders (like schizophrenia). The program used simulated daily-life challenges to improve thinking and daily function…

This small pilot study tested whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) could help people with bipolar disorder improve their emotion regulation. Nineteen participants, including both patients and healthy controls, completed…

This study looked at how well valbenazine works for tardive dyskinesia (TD), a condition causing uncontrollable movements often linked to long-term use of certain mental health medications. Fifty-nine adults with schizophrenia, bipolar disorder, or major depression took valbenazi…

This small pilot study tested whether a ketone supplement plus a special diet could help people with bipolar disorder. Fifteen adults took part, and researchers measured changes in blood ketone and glucose levels. The goal was to see if this approach is safe and worth studying fu…

This study tested a computer-based cognitive training program in 72 adults with bipolar disorder who also had psychosis. The goal was to see if the training could improve memory, attention, and problem-solving skills compared to a control computer activity. Participants were with…

This study tested whether group-based psychoeducation (classes about bipolar disorder) could reduce stress and mood instability in relatives of people with bipolar disorder. 206 relatives participated, using a smartphone app to track their daily mood. The goal was to see if learn…

This study tested a new artificial intelligence tool called CBTpro that helps therapists improve their skills in cognitive behavioral therapy for people with psychosis. Over 600 adults with conditions like schizophrenia or bipolar disorder took part. The goal was to see if the to…

This study tested a program called Illness Management and Recovery (IMR) for adults with schizophrenia or bipolar disorder. The goal was to see if the program helps improve daily functioning and overall well-being. 198 participants from community mental health centers in Denmark …

This study compared the sense of smell (odor threshold, discrimination, and identification) between 240 people with bipolar disorder and healthy volunteers. Researchers also looked at brain scans to see if smell performance was linked to brain structure or activity. The goal was …

This study looked at whether smartphone data—like activity, sleep, and social patterns—could help track symptoms in 87 veterans with serious mental illnesses such as schizophrenia, bipolar disorder, or PTSD. Participants used an app that passively collected this data. The goal wa…

This study followed 300 pregnant women with and without mood disorder histories to uncover why some develop postpartum depression or psychosis. Researchers collected genetic, hormonal, and environmental data like sleep and stress to identify risk factors. The goal is to eventuall…

This study tested whether sending text message reminders to young people (ages 14-35) who had a first episode of psychosis could help them attend their first appointment at an early psychosis program after being seen in the emergency department. The study involved 186 participant…

This study looked at how alcohol changes the brain and feelings in 60 young adults (21-26 years old), half with bipolar disorder and half without. Participants drank alcohol or a placebo during brain scans and reported how they felt. The goal was to understand why people with bip…

This study looked at how the body builds tolerance to Igalmi (a fast-acting medicine for agitation) and what happens when it's stopped. It involved 29 adults with schizophrenia or bipolar disorder who had frequent agitation. Researchers measured changes in agitation levels and wa…

This study looked at whether a digital training platform helps clinicians use a smartphone app called FOCUS to support people with serious mental illness like schizophrenia or bipolar disorder. 191 adults used the app and received coaching from trained clinicians. The goal was to…

This study tested a new automated phone system called 'My Coach Connect' for people with chronic mental illness, including depression, schizophrenia, and bipolar disorder. Participants called the system twice a week to answer questions about how they were doing, and their respons…

This pilot study tested a telehealth program called CRAFT-EP for families of people with early psychosis who also use alcohol or cannabis. 65 family members took part to see if the program could improve their wellbeing, including reducing depression and anxiety. The goal was to l…

This study looked at how a gentle brain stimulation technique called TBS affects brain activity and emotions in adults with and without bipolar disorder. Researchers wanted to understand what happens in the brain during reward processing. 146 adults took part. The goal was to lea…

This early-stage study tested a new oral drug, SEP-380135, in 43 adults with schizophrenia or major depression (including bipolar disorder). The main goal was to check if the drug is safe and how the body processes it. Researchers measured side effects, vital signs, and mood chan…

This study looked at whether a non-invasive brain stimulation technique called TMS can help people with bipolar disorder regulate their emotions. Researchers used brain scans and special tasks to measure emotional control in 56 participants. The goal was to understand how TMS aff…

This study looked at how the COVID-19 pandemic affected the mental health of 193 Amish and Mennonite adults who already had depression, anxiety, or bipolar disorder. Participants filled out surveys about their symptoms and pandemic-related stress four times over two years. The go…

This study tested a new way to improve thinking skills by combining brain-training games with low-oxygen air (like being at high altitude). 190 healthy adults and people with depression or bipolar disorder took part. The goal was to see if this approach could boost memory, focus,…

This study used brain scans (fMRI) to understand why people with bipolar disorder sometimes have disorganized thoughts and speech. Researchers compared 79 participants—some with bipolar disorder and healthy volunteers—while they performed thinking tasks. The goal was to learn mor…

This study used MRI and PET scans to examine the glutamate system in people with major depression, PTSD, or bipolar disorder. Researchers aimed to understand how a specific glutamate receptor (mGluR5) relates to these conditions. 180 participants aged 18-70 completed cognitive te…

This study tested whether alerting police officers that a person has a serious mental illness during a routine check can reduce arrests and help them stay in treatment. About 1,400 adults with conditions like schizophrenia, bipolar disorder, or major depression who had been arres…