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Zapping the back of the brain to lift teen depression?

NCT ID NCT05929183

Symptom relief Sponsor: First Affiliated Hospital of Zhejiang University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new way to use repetitive transcranial magnetic stimulation (rTMS) to treat depressive episodes in 40 adolescents with bipolar disorder. Instead of the usual front-brain target, researchers stimulated the visual cortex at the back of the brain, aiming to affect mood-related circuits. The goal was to see if this approach could safely and quickly improve symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS) device
What this could lead to
If it works, this could point toward a faster, safer way to improve mood in teens with bipolar depression.
What could go wrong
This is a small, early-stage study with only 40 participants. The new stimulation target may not work better than existing methods, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Sep 2022

Finished

Jul 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

14 to 28 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 14-28 years old, regardless of gender; 2. Meet DSM-V diagnostic criteria for bipolar depressive episodes; 3. Young Mania Rating Scale (YMRS) ≤ 6 points; 4. MARDS:12-30 points. 5. Han nationality, right-handed; 6. More than 9 years of education. Exclusion Criteria: 1. History of severe somatic or brain organic diseases and craniocerebral trauma; 2. Abnormal brain structure or any MRI contraindications were found by magnetic resonance examination; 3. Those who do not cooperate or cannot effectively complete the experiment; 4. Drug, alcohol or other psychoactive substance abusers; 5. Pregnant, lactating or planned pregnancy. 6. Severe suicidal ideation and behavior 7. ECT or rTMS treatment was performed within six months

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Conditions

The condition(s) this trial relates to.

bipolar depression bipolar disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bipolar disorder

Contacts and locations

Locations

  • The First Affiliated Hospital of Zhejiang University

    Hangzhou, Zhejiang, 310000, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.