First Affiliated Hospital Of Zhejiang University

This study tests whether adding the immunotherapy drug toripalimab to standard chemotherapy before surgery can help eliminate triple-negative breast cancer in 35 women. Participants will receive the combination treatment, then have surgery to check if no cancer remains. The goal …

This study tests a noninvasive brain stimulation technique (temporal interference stimulation) in 70 people with stable bipolar disorder who also have obesity. The goal is to see if targeting a brain region that controls body rhythms can improve metabolism and weight. Participant…

This early-phase study tests a new treatment called A-CAR028 for people with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment uses specially engineered immune cells (CAR-T cells) to find and attack cancer cells. The main goals ar…

This study tests a new treatment plan for adults with a specific type of acute myeloid leukemia (AML) that has a FLT3-ITD mutation. The goal is to see if a combination of targeted drugs (gilteritinib, venetoclax, and azacitidine) followed by high-dose chemotherapy can control the…

This study tests whether a short course of radiation followed by chemotherapy and two immunotherapy drugs can help people with a certain type of locally advanced rectal cancer avoid surgery and keep their rectum. About 116 adults aged 18-75 with MSS or pMMR rectal cancer will tak…

This study tests whether adding venetoclax (a targeted pill) to standard chemotherapy before a donor stem cell transplant can improve outcomes for adults over 50 with acute myeloid leukemia or myelodysplastic syndrome. About 186 participants will be randomly assigned to receive e…

This study tests a new combination of three drugs (mitoxantrone, cytarabine, and venetoclax) for adults whose acute myeloid leukemia has come back or not responded to earlier treatment. The goal is to see if this combination can help more patients achieve remission. About 72 part…

This study tests a new treatment approach for people with rectal cancer that has spread to a limited number of other organs (oligometastases). The treatment combines short-course radiation, chemotherapy, and an immunotherapy drug called serplulimab. The goal is to see if this com…

This study tests whether adding venetoclax to the standard chemotherapy given before a stem cell transplant can help prevent the cancer from coming back in people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). About 138 participants aged 12 to 60 …

This study tests whether a drug called romiplostim N01 can help rebuild platelets faster after a stem cell transplant for blood cancers like leukemia. About 130 adults will receive either the drug or standard care. The goal is to see if the drug reduces bleeding risk and speeds r…

This study tests whether adding two drugs (sintilimab and bevacizumab) to standard chemotherapy before surgery can eliminate all signs of triple-negative breast cancer in 37 women. The main goal is to see how many patients have no cancer left in the removed tissue. This approach …

This study tests two drugs, trastuzumab rezetecan and toripalimab, given before surgery to people with HR-positive, HER2-low breast cancer. The goal is to see if this combination can completely eliminate the tumor in the breast at the time of surgery. About 111 women aged 18-70 w…

This study tests whether etamsylate, a drug that helps blood clot, can prevent serious bleeding in people with very low platelet counts after a stem cell transplant. About 404 adults will receive either etamsylate or a placebo, and researchers will track who has major bleeding or…

This study tests a new drug called gecacitinib (jaktinib) combined with standard steroids as a first treatment for acute graft-versus-host disease (GVHD) in people who had a stem cell transplant. GVHD is a serious condition where donor cells attack the patient's body. The trial w…

This study looks at whether using two types of blood thinners (anticoagulant plus antiplatelet) after a vein stent procedure helps keep the vein open longer and prevents blood clots from returning. About 172 people with deep vein thrombosis and a narrowed iliac vein will take par…

This study tests whether adding etanercept to the standard drug ruxolitinib works better for severe graft-versus-host disease (GVHD) that doesn't respond to steroids. GVHD is a life-threatening complication after a stem cell transplant where donor cells attack the patient's body.…

This study will follow 400 people with early Alzheimer's disease who are taking lecanemab, a drug that removes amyloid plaques from the brain. Researchers want to see if simple blood tests can track the drug's effects as accurately as brain scans. The goal is to make monitoring e…

This study tests a new drug, orelabrutinib, combined with chemotherapy for people newly diagnosed with marginal zone lymphoma, a rare blood cancer. About 69 participants will receive the treatment to see if it improves tumor shrinkage and helps control the disease long-term. The …

This study tests a new treatment plan for people aged 60 and older who have been newly diagnosed with acute myeloid leukemia (AML) and cannot have strong chemotherapy. The treatment uses two different drug combinations given one after the other. The goal is to see if this approac…

This study tests if a special stent can safely block blood flow to brain aneurysms (weak spots in blood vessels). About 164 people aged 18-80 with certain types of aneurysms will receive the stent. The main goal is to see if the aneurysm is fully sealed one year after the procedu…

This study is testing whether a special type of PET/MRI scan can accurately diagnose and track myelofibrosis, a serious bone marrow disorder. About 57 adults with the condition will get both a standard PET scan and the new FAPI PET/MRI. The goal is to see if the new scan can matc…

This study is testing a new type of MRI scan to see if it can find prostate cancer more accurately than current methods. About 2000 men with suspected prostate cancer will get this special MRI, and the results will be checked against standard biopsies. The goal is to develop a be…

This study tests if 12 weeks of supervised dragon boat racing improves body composition, physical function, and quality of life more than unsupervised home exercise in women who had breast cancer surgery. 72 participants will be randomly assigned to either group. The goal is to f…

This study tests a new way to give oxygen during a lung scope (bronchoscopy) to prevent dangerously low oxygen levels. About 50 adults will receive a thin breathing tube through the nose instead of a standard airway device. The goal is to see if this method is safer and reduces b…

This study tests if a newer sedative called remimazolam can lower the chance of low oxygen levels (hypoxia) during a painless lung scope procedure in patients at high risk. About 360 adults with serious health conditions will be randomly assigned to receive either remimazolam or …

This study looks at very small movements (micro-movements) in people who have been unconscious for a long time after a severe brain injury. The goal is to see if these movements can help doctors better understand a patient's level of awareness and improve diagnosis. Researchers w…

This study is developing an AI model to predict the risk of serious bleeding after stomach cancer surgery, helping doctors decide if a second operation is needed. It will involve 7,000 adult patients who have had their stomach removed due to cancer. The AI will analyze routine me…

This study compares a new type of laryngeal mask (GMA) with the traditional one used during general anesthesia. Researchers want to see which one is safer, more effective, and more comfortable for patients. About 1,384 adults having elective surgery will take part, and the result…

This study looks at tiny, involuntary facial expressions (micro-expressions) in 200 people with long-term consciousness disorders. Researchers use emotional stimuli to trigger these expressions and combine them with brain scans (EEG, MRI) to better classify a patient's level of a…