First Affiliated Hospital Of Zhejiang University

This early-stage trial tests a two-step approach to target hidden HIV. First, a drug called chidamide wakes up dormant HIV hiding in cells. Then, specially designed natural killer (NK) cells are infused to find and destroy those infected cells. The study enrolls 20 adults with we…

This study tests a pill called iptacopan for people who develop a serious blood vessel condition (TA-TMA) after a stem cell transplant. The drug aims to block harmful immune activity and improve survival. About 30 participants will take the pill and be monitored for up to 2 years…

This study tests a new way to treat a serious tear in the main artery (type B aortic dissection). The standard procedure uses a stent-graft to close the main tear, but blood can still leak through smaller tears, causing the artery to widen and need more procedures. This study add…

This study tests a new combination of drugs (homoharringtonine, a BCL-2 inhibitor, rituximab, and prednisone) in adults whose diffuse large B-cell lymphoma has come back or not responded to standard treatment. The goal is to find the safest dose and see if the combination shrinks…

This study tests if a precise, minimally invasive surgery (stereotactic aspiration) can improve outcomes for people with severe brain stem bleeding compared to standard medical care. The trial will enroll 300 adults with large hematomas and severe symptoms. The main goal is to se…

This study will test a new type of PET/CT scan called 18F-FAPI to see how well it can find lung cancer and predict patient outcomes. About 120 people with lung cancer will get this scan. The goal is to improve diagnosis and help doctors make better treatment decisions.

This study will test a special type of PET scan (18F-FAPI PET/CT) in 120 people whose cancer started from an unknown location. The goal is to see if this scan can better find where the cancer began, help doctors choose the right treatment, and predict outcomes. Participants will …

This study aims to see if combining a special PET scan (18F-FAPI) with detailed MRI can improve how doctors diagnose and predict outcomes for gastric cancer. About 230 people with suspected or confirmed gastric cancer will receive both scans. The goal is to measure how accurate t…

This study will see if a special PET scan (18F-Octreotide) can more accurately find neuroendocrine tumors, help doctors plan treatment, and predict how the disease will progress. About 152 adults who have or are suspected of having these tumors will get the scan. The goal is to i…

This study tests whether a probiotic called Bifidobacterium PB-18 can help adults with mild to moderate depression. Participants will take either the probiotic or a placebo daily for 8 weeks, and researchers will track mood changes and side effects. The goal is to see if improvin…

This study tests whether taking inulin (a fiber) and spirulina (a type of algae) can improve sleep in adults aged 18 to 60 with chronic insomnia. 180 participants will be split into four groups: inulin alone, spirulina alone, both together, or a placebo. They will take the supple…

This study tests a noninvasive brain stimulation technique called transcranial magnetic stimulation (TMS) to see if it can improve memory and thinking in people with bipolar disorder. Researchers will enroll 88 adults with stable bipolar disorder and give them either real or fake…

This study looks at brain wave patterns in 48 adults having arm or leg surgery under nerve blocks and sedation. Researchers want to understand how the brain behaves when a person is unconscious from anesthesia and when they wake up. The goal is to learn more about sedation depth …

This study looks at whether giving a daily G-CSF shot in the morning or evening helps healthy stem cell donors produce more cells for transplant. About 160 donors will get the shot at either 8 AM or 8 PM for five days. The goal is to find a simple schedule that works best for col…

This study looks at different breathing machine settings used during lung surgery (VATS) to find which one causes the fewest lung problems after surgery. About 650 adults over age 50 having lung cancer surgery will take part. The goal is to find the best way to protect the lungs …

This study will observe 132 people who had a procedure to fix a tear or bulge in their main artery (aorta). The goal is to measure different types of discomfort they may feel afterward, such as back pain, skin irritation from bandages, trouble moving, and stress. The results will…

This is a randomized, double-blind, placebo-controlled, parallel-group, prospective, multi-center clinical trial, to evaluate the efficacy of silkworm pupa tablets in improving nutritional status and sarcopenia in patients with malignancies who have completed comprehensive treatm…