BIPOLAR DISORDER

This study aimed to test whether a 10-week lifestyle program called 'Lifestyle MIND' is a practical way to help people with serious mental illness (like schizophrenia or bipolar disorder) manage their type 2 diabetes. Researchers planned to compare people who started the program …

This study is testing a personalized program designed to help people with bipolar disorder take their prescribed mood-stabilizing medications more consistently. About 190 adults with bipolar disorder who have had trouble taking their medications will participate. The program iden…

This study aims to understand the long-term safety and effectiveness of the drug azetukalner for adults with bipolar depression. It is open to 400 participants who successfully completed a previous Phase 3 trial of the same drug. The main goal is to monitor side effects and see i…

This study is testing how well a combination of medication and a specific type of talk therapy (cognitive behavioral therapy) helps people with various mental health conditions. It involves 107 adults with diagnoses like anxiety, depression, PTSD, bipolar disorder, or schizophren…

This study is testing a new, gentler form of brain stimulation called TEST for people with severe depression that hasn't improved with standard treatments. It aims to see if TEST can safely reduce depression symptoms without the memory problems sometimes caused by stronger therap…

This study is testing if personalized text message reminders can help people who have both high blood pressure and a mood disorder (like depression or bipolar disorder) remember to take their blood pressure medicine. Researchers are comparing two groups: one gets text reminders p…

This study is testing whether a 'shared decision-making' approach helps people with bipolar disorder stick to their long-term medication plan. It involves 300 adults who have recently recovered from a mood episode. Researchers will compare this collaborative approach to standard …

This study is testing whether mindfulness-based therapy can help people with serious mental illnesses like schizophrenia, depression, and bipolar disorder. Researchers are comparing regular treatment alone to regular treatment plus mindfulness therapy delivered by community menta…

This study is testing if adding supervised aerobic exercise to regular medication helps people with bipolar depression get better faster and stay well longer. It will involve 54 participants who are randomly assigned to either do exercise, relaxation, or just get information for …

This study aimed to test a medication called BXCL501, a small dissolving film placed under the tongue, for quickly calming severe agitation in adults with bipolar disorder or schizophrenia arriving at the emergency department. The goal was to see how well and safely it worked in …

This study is testing whether a creative writing group program helps people with serious mental illnesses like schizophrenia, bipolar disorder, or severe depression. About 300 participants will either join the writing groups along with their usual care or continue with usual care…

This study aims to understand how a magnetic stimulation treatment affects the brain in older adults with bipolar depression. Researchers will use brain scans before and after treatment to measure changes in brain activity. The goal is to gather information that could help guide …

This study aims to understand how lithium, a common treatment for bipolar disorder, changes the brain's wiring and activity. Researchers will use MRI brain scans on about 120 people with bipolar depression and healthy volunteers over 26 weeks to see how brain connections shift wi…

This research project aims to understand the genetic and biological roots of serious mental health conditions like major depression, bipolar disorder, and psychotic disorders. It involves collecting DNA, brain scans, and detailed health information from 2,000 participants, includ…

This study aims to identify genes that may increase a person's risk of developing bipolar disorder. Researchers are analyzing DNA from over 4,000 adults who have bipolar disorder or are related to someone with the condition. The goal is to understand the genetic causes better, wh…

This study aims to better understand how bipolar disorder changes and progresses over time. Researchers will follow 126 people in Italy for 18 months, collecting information from interviews, blood tests, and brain scans. The goal is to combine all this data to create a more detai…