BIPOLAR DISORDER

This study looks at whether adding cognitive behavioral therapy (a type of talk therapy) to standard medication can improve symptoms and daily functioning for people with conditions like anxiety, depression, OCD, PTSD, bipolar disorder, schizophrenia, and personality disorders. A…

This study tests a customized program called Customized Adherence Enhancement (CAE) to help people with bipolar disorder take their medications as prescribed. About 190 participants who have trouble sticking to their medication will be randomly assigned to either the CAE program …

This study tests a program to reduce or stop anticholinergic medications in adults with schizophrenia, bipolar disorder, or other serious mental illnesses when these drugs are no longer needed. About 111 participants from UPMC clinics will be guided to taper off these medications…

This study aimed to see if a lifestyle program called Lifestyle MIND could help people with serious mental illness manage or prevent type 2 diabetes. Participants would have been randomly assigned to join the program right away or later. The study was withdrawn before any partici…

This study tests a personalized mobile health program (iTAB-CV + Self-Monitoring) to help people with bipolar disorder or major depression stick to their blood pressure medications. 176 participants will be randomly assigned to use the app plus self-monitoring, or self-monitoring…

This study looks at whether involving bipolar patients in decisions about their preventive treatment helps them take their medication as prescribed. Researchers will compare standard care to a shared decision-making plan in 300 adults after a mood episode. The goal is to see if t…

This study tests the long-term safety and effectiveness of azetukalner in 400 adults with bipolar I or II depression who already completed a previous study on the same drug. Participants will take the medication openly (everyone knows they are getting it) for an extended period. …

This pilot study tests a youth-friendly therapy called NECT-Y to see if it can reduce self-stigma in 96 young people with bipolar disorder or multiple mental health conditions. Participants will either join a 14-week virtual group therapy or continue their usual care. The main go…

This study tests a new treatment called TEST that uses a weaker electric current than standard electroconvulsive therapy (ECT) for people with depression that hasn't improved with other treatments. The goal is to see if TEST is safe, practical, and can help lift depression while …

This study tests a 15-session creative writing program called REWRITALIZE for people with severe mental illness, including schizophrenia and bipolar disorder. The program is led by a professional author and aims to improve personal recovery, thinking skills, and social connection…

This study tests a 6-session virtual program called Future Self-BD for adults with bipolar disorder who want to quit smoking. Participants learn to vividly imagine positive future events that could happen if they stop smoking. The study aims to see if this approach is acceptable …

This study looks at whether moderate-to-vigorous aerobic exercise can speed up recovery from bipolar depression and help prevent future depressive episodes. Fifty-four adults with bipolar disorder and current depression will be randomly assigned to either supervised aerobic exerc…

This study tests whether adding mindfulness-based therapy to usual care helps people with serious mental illness (like schizophrenia, bipolar disorder, or major depression) feel better and improve their quality of life. Researchers will enroll 160 adults from a community mental h…

This study aimed to see if a sublingual film of dexmedetomidine (BXCL501) could quickly reduce agitation in adults with bipolar disorder or schizophrenia visiting the emergency department. It was a single-arm pilot study, but it was withdrawn before enrolling any participants. No…

This study aims to find clues that show which patients with treatment-resistant depression will respond best to a single dose of IV ketamine. Researchers will study 40 adults with depression or bipolar disorder who haven't improved with other treatments. Participants will receive…

This study aims to find genes that may increase the risk of developing bipolar disorder. Researchers will analyze genetic information from 4,185 adults aged 18 and older. The goal is to better understand the biological causes of bipolar disorder, which could lead to improved diag…

This study looks at how lithium, a common treatment for bipolar disorder, affects the brain's wiring. Researchers will use MRI scans to track changes in brain connections over 6 months in 120 adults with bipolar depression. The goal is to understand why lithium works, not to test…

This study aims to collect DNA, brain images, and other biological samples from 2,000 people with major depression, bipolar disorder, or psychotic disorders, as well as healthy volunteers. By analyzing these samples, researchers hope to find physical and genetic factors that can …

This study looks at how low field magnetic stimulation changes brain activity in people aged 60 and older with bipolar depression. About 40 participants will have brain scans before and after real or fake treatment on two separate days. The goal is to understand the brain effects…

This study observes 126 adults with bipolar disorder over 18 months to track how the condition progresses. Researchers collect blood, saliva, and brain scans to find biological markers that could predict changes. The goal is to create a better system for staging the illness, whic…