Sun Yat-sen Memorial Hospital Of Sun Yat-sen University

This phase 2 trial tests whether adding one of four different drugs to a standard immunotherapy combination can help people with HER2-positive muscle-invasive bladder cancer avoid bladder removal. Participants receive disitamab vedotin and toripalimab plus a sensitizing agent, th…

This study looks at whether taking vitamin B3 (a common dietary supplement) can stop antibiotics from weakening the immune system's ability to fight bladder cancer. The trial includes people with a certain type of bladder cancer who have recently taken antibiotics. They will rece…

This study tests whether combining procedures that block blood flow to liver tumors (TACE or HAIC) with targeted drugs and immunotherapy can help control advanced hepatocellular carcinoma that cannot be surgically removed. The trial enrolls adults aged 18–80 with large or vein-in…

This study tests a combination of two drugs (apatinib and adebrelimab) plus chemotherapy (GEMOX) as a first treatment for people with advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer that cannot be removed by surgery. The goal is to see if this mix shrinks tum…

This study tests a drug called tenecteplase (TNK) for people who have had a stroke caused by a blood clot in the brain. The drug is given up to 24 hours after symptoms start, using only a simple CT scan to decide who can get it. The goal is to see if TNK helps people recover bett…

This phase 2 trial is testing a combination of three drugs—adebrelimab, apatinib, and tegafur—in 32 people with advanced esophageal cancer that has not responded to first-line immunotherapy. The goal is to see if this new mix can shrink tumors or slow the disease. Participants wi…

This study tests whether adding adalimumab to standard chemotherapy and radiation before surgery can help eliminate esophageal cancer more effectively. About 37 adults with resectable esophageal squamous cell carcinoma will receive this combination. The main goal is to see how ma…

This study tests whether adding tofacitinib to standard methotrexate works better than methotrexate alone for people with active rheumatoid arthritis who have a specific 'myeloid-stromal' type. 130 adults will be randomly assigned to either the combo or methotrexate-only group fo…

This phase III trial tests whether adding ribociclib to standard hormone therapy (aromatase inhibitor) can prevent breast cancer from coming back in women with hormone receptor-positive, HER2-negative early breast cancer who still have cancer after initial chemotherapy. About 446…

This study tests whether taking an oral chemotherapy (paclitaxel) along with a fixed-dose injection of two targeted drugs (pertuzumab and trastuzumab) can eliminate all signs of HER2-positive breast cancer before surgery. About 112 adults with early-stage HER2+ breast cancer will…

This Phase 3 trial tests whether a combination of three drugs—camrelizumab, apatinib, and eribulin—works better than standard chemotherapy for advanced triple-negative breast cancer. The study will enroll 246 women aged 18 to 70. Researchers will measure how long the cancer stays…

This study tests whether adding a clot-dissolving medicine directly into the brain's arteries during standard clot-removal procedures helps people recover better after a stroke caused by a medium-sized blockage. About 530 adults with acute ischemic stroke will be randomly assigne…

This early-phase trial is testing a new treatment for people with advanced mesenchymal malignancies (a group of rare cancers including sarcomas). The treatment uses the patient's own immune T cells, which are modified in a lab to recognize and attack cancer cells that carry a pro…

This phase II trial is testing whether adding an immunotherapy drug (PD-1 antibody) to standard chemotherapy (GEMOX) after surgery can help prevent cancer from returning in people with perihilar cholangiocarcinoma that has spread to nearby lymph nodes. The study plans to enroll 6…

This study tests whether giving immunotherapy every 6 weeks instead of every 3 weeks works as well for advanced triple-negative breast cancer. The goal is to keep the cancer under control while reducing side effects and improving quality of life. About 416 participants whose canc…

This study is tracking 300 people with HER2-positive or HER2-low breast cancer who are receiving trastuzumab-rezetecan as part of their routine care. Researchers are monitoring side effects and how well the drug works in real-world conditions, not in a strict lab setting. The goa…

This phase 2 trial tests a new treatment plan for people with a certain type of advanced breast cancer (HR-positive, HER2-low or ultra-low). Participants first receive trastuzumab rezetecan alone for several months, then switch to a combination of CDK4/6 inhibitors and hormone th…

This study tests a drug called tenecteplase in people who have had a stroke and recently took a blood thinner (DOAC). The goal is to see if the drug helps them recover better after 90 days. About 912 participants will receive either tenecteplase or a placebo within 24 hours of th…

This study compares two surgical approaches for papillary thyroid cancer that has spread to lymph nodes in the neck: robotic surgery through the armpit versus traditional open surgery. The goal is to see if the robotic method offers similar cancer control and survival rates while…

This phase 2 trial is testing a drug called Hetrombopag to raise platelet counts in 56 breast cancer patients who developed low platelets (thrombocytopenia) after T-DM1 therapy. The goal is to see if the drug can safely keep platelets at a safe level so patients can continue thei…

This study tests two different ways to give chemotherapy combined with immunotherapy and a targeted drug for people with advanced liver cancer (BCLC stage C). One group gets standard IV chemo plus the drugs camrelizumab and apatinib. The other group gets the same drugs but with c…

This Phase 3 trial tests whether a combination of trastuzumab and neratinib works better than the standard trastuzumab and pertuzumab for women with a certain type of breast cancer (HER2-positive, hormone receptor-positive) who still have small amounts of cancer after initial che…

This study tests whether adding hydroxychloroquine (an anti-inflammatory drug) to levothyroxine (a thyroid hormone) can increase live birth rates in women with thyroid antibodies and unexplained recurrent pregnancy loss. About 800 women will take either the combination or levothy…

This study is testing whether a genetic test called RecurIndex can identify breast cancer patients with cancer in their lymph nodes who can safely skip radiation to the lymph nodes. The goal is to reduce side effects like arm swelling and pain without increasing the risk of cance…

This early-phase trial tests a personalized cell therapy called TCR-T cells, engineered to recognize and attack cancer cells with a specific KRAS mutation. Up to 18 adults with advanced pancreatic cancer who have exhausted standard treatments will receive a single infusion of the…

Urological diseases like kidney stones, prostate cancer, and bladder cancer are common but require expert diagnosis. This study will develop and test an AI assistant called UroAgent that helps doctors make decisions by analyzing patient records and images. Researchers will use 2,…

This study aims to develop an AI model that combines ultrasound images and cell slide images to more accurately predict cancer risk in thyroid nodules that have uncertain results from a needle biopsy. About 396 patients with these uncertain results will be included. The goal is t…

This study tests whether adding contrast-enhanced ultrasound to standard ultrasound can improve the diagnosis of thyroid cancer. Researchers are comparing two scoring methods in 800 participants with thyroid nodules. The goal is to see which method better identifies cancer and re…

This study looks at whether a special type of ultrasound (contrast-enhanced ultrasound) can predict how much cancer has spread to lymph nodes in patients with early-stage thyroid cancer. Researchers will review past images from 600 patients and compare them to surgical results. I…

This study is developing an artificial intelligence (AI) model to detect whether cancer has spread to lymph nodes by analyzing digital images of tissue slides. Researchers will compare the AI's accuracy to that of pathologists using slides from 10,000 cancer patients. The goal is…

This study tests whether giving vaginal progesterone gel for a longer time can prevent preterm birth in women who became pregnant through IVF with a fresh embryo transfer. About 100 women aged 20-40 with a single pregnancy will be enrolled. Researchers will compare preterm birth …

This study tests whether wearing compression gloves and stockings during chemo, plus acupuncture after, can prevent nerve damage (peripheral neuropathy) in breast cancer patients. About 384 people will be randomly assigned to one of four groups: compression only, acupuncture only…

This trial tests whether using surface-guided radiation therapy (SGRT) with an open-face mask can make radiotherapy more comfortable and precise for people with head and neck cancer. Forty newly diagnosed patients will be randomly assigned to receive radiation with either the ope…

This study tests whether taking probiotics can prevent severe diarrhea in women with HER2-positive breast cancer who are treated with neratinib. About 308 participants will be randomly assigned to receive either probiotics or a placebo for six weeks, alongside standard diarrhea p…

This study compares a newer, less invasive mastectomy technique (endoscopic skin-sparing) with the standard approach in 258 women with breast cancer. The goal is to see if the endoscopic method leads to fewer wound complications and higher patient satisfaction. Participants are r…

This study tests whether adding fascial manipulation to standard shock wave therapy improves pain and knee function in people with patellar tendinitis (jumper's knee). 38 adults aged 18-45 will be randomly assigned to receive either shock wave therapy alone or combined with targe…

This study compares two painkiller combinations—dezocine plus sufentanil versus nalbuphine plus sufentanil—for pain relief after oral cancer surgery with flap reconstruction. Sixty adults will receive one of the two combinations through a patient-controlled pump. The goal is to s…

This study looks at whether combining a non-invasive brain stimulation technique called rTMS with hearing aids can improve cognitive function in older adults with age-related hearing loss. About 189 participants, including those with and without hearing aids, will receive two 14-…

This study tests if an external oil can reduce severe breast pain in premenopausal women. About 190 women will apply either the oil or a placebo for three menstrual cycles. The main goal is to see if the oil cuts pain by at least half. This is a phase 3 trial, meaning it's in the…

This study tests whether a personalized form of brain stimulation (TMS) can better reduce chronic tinnitus (ringing in the ears) than the standard approach. 116 adults with bothersome tinnitus for over 6 months will receive five days of stimulation, with their progress tracked fo…

This study tests whether a large language model (AI) can help junior doctors write more accurate and efficient cancer treatment reports. Forty doctors will be split into two groups: one using AI assistance, the other using traditional methods. The reports will be scored by expert…

This study is developing an artificial intelligence system to help surgeons find and check the blood supply of the parathyroid glands during thyroid surgery. The parathyroid glands are small and hard to see, and damaging them can cause serious side effects. The AI will be trained…

This observational study looks at 255 women with HER2-low breast cancer to understand how certain gene changes (HRD/HRR) relate to survival. Researchers will analyze tumor and blood samples to map these genetic features. The goal is to learn more about this cancer type, not to te…

This study looks at whether women with a certain type of breast cancer (hormone-sensitive, HER2-negative, with 1-3 positive lymph nodes and a low RecurIndex score) can safely avoid radiation therapy to the lymph nodes. Researchers will follow 635 participants over time to see how…