New drug combo aims to stall advanced breast cancer
NCT ID NCT07037199
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests a new treatment plan for people with a certain type of advanced breast cancer (HR-positive, HER2-low or ultra-low). Participants first receive trastuzumab rezetecan alone for several months, then switch to a combination of CDK4/6 inhibitors and hormone therapy. The goal is to see if this sequence can delay cancer growth. The study will enroll 45 patients and track how long they live without the disease getting worse.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Trastuzumab rezetecan, CDK4/6 inhibitors (dalpiciclib, abemaciclib, ribociclib, palbociclib), and endocrine therapy (fulvestrant or aromatase inhibitors)
What this could lead to
If successful, this sequential treatment approach could provide a new option to control advanced breast cancer for longer before the disease worsens.
What could go wrong
This is a small, early-phase trial with only 45 participants, so results may not apply to all patients. Side effects from the drug combination could be significant.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Sun Yat-sen Memorial Hospital
RECRUITINGGuangzhou, Guangdong, 510120, China
Contact Phone: •••-•••-•••• Email: •••••@•••••