Sun Yat-sen Memorial Hospital Of Sun Yat-sen University

This study tests a new approach for treating high-grade cervical precancer (HSIL) using a cream called HAL that is activated by a special light, instead of standard surgery. About 230 women will be randomly assigned to receive either the light therapy or surgery. The main goal is…

This trial tests whether giving trilaciclib before chemotherapy and immunotherapy can protect bone marrow in people with advanced head and neck cancer. The goal is to reduce dangerous drops in blood cell counts, allowing patients to receive their full chemo doses on schedule. Abo…

This trial investigates whether giving radiotherapy after surgery can prevent local recurrence in people with a rare breast tumor called phyllodes tumor, specifically those with high-risk molecular subtypes (MN1 or MN2). Participants who have had complete tumor removal will be ra…

This study tests a combination of the immunotherapy drug sintilimab and a chemotherapy regimen called FOLFIRI as a second-line treatment for people with advanced HER2-negative stomach cancer that has progressed after initial therapy. The goal is to see if this approach can delay …

This study tests whether a new drug, trastuzumab rezetecan, works as well as or better than the current drug trastuzumab deruxtecan for women with advanced HER2-positive breast cancer that has worsened after previous treatment. About 100 women will be randomly assigned to one of …

This phase 2 trial is testing a combination of three drugs—inavolisib, ribociclib, and fulvestrant—in 160 Chinese women with a specific genetic mutation (PIK3CA) in hormone receptor-positive, HER2-negative advanced breast cancer that has stopped responding to endocrine therapy. T…

This early-stage trial tests whether tocilizumab, an anti-inflammatory drug, can help women with a rare breast condition called granulomatous lobular mastitis that hasn't improved with steroids. About 31 women aged 20-50 will receive two doses of the drug intravenously. The main …

This study tests a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) in 23 smokers aged 40-75 with PRISm, a lung condition that often progresses to COPD. Participants will use the inhaler twice daily for 12 weeks. The goal is to see if it improves lung funct…

This study compares a new method that combines a non-invasive genetic test (NICS) with artificial intelligence (AI) against the standard way of picking embryos by looks alone. It includes 520 women aged 35-43 or with a history of recurrent miscarriage who are doing IVF. The goal …

This study looks at whether removing keloids surgically and then applying a radioactive patch (32P) can prevent them from returning. About 401 people with keloids will get this treatment and be checked every 6 months for 2 years. The goal is to see how well the combo works and wh…

This study tests a daily pill called hetrombopag to see if it can safely raise low platelet counts in women with gynecological cancers (like ovarian or cervical cancer) after chemotherapy. About 244 women whose platelets dropped too low will take the drug to help them complete th…

This study compares a single chemotherapy drug (paclitaxel) to the standard two-drug combo (paclitaxel plus carboplatin) as initial treatment before surgery for advanced ovarian cancer. It is for patients whose tumors have high levels of a protein called PARK2, which may make the…

This study tests whether blocking the artery that feeds a bile duct tumor before surgery can make it possible to remove the cancer safely. It includes 33 adults with advanced bile duct cancer that currently cannot be operated on. The main goal is to see how many patients are aliv…

This study tests a new mRNA vaccine designed to help the immune system attack cancer cells. The vaccine targets a protein found only in tumors and is given together with an immunotherapy drug (anti-PD-1). About 60 adults with advanced solid tumors that cannot be removed by surger…

This phase 2 trial tests a combination of three drugs—liposomal irinotecan, sintilimab, and anlotinib—in 36 people with recurrent or persistent ovarian clear cell carcinoma. The goal is to see if the treatment can shrink tumors and control the disease. Participants must have alre…

This study tests three different doses of the drug famitinib combined with camrelizumab in 120 people with recurrent or metastatic cervical cancer that cannot be cured by standard treatments. The goal is to find a dose that keeps the cancer under control while causing fewer sever…

This study tests whether adding the steroid methylprednisolone to standard clot-removal treatment helps people recover from severe stroke. About 912 adults aged 18–85 with a large clot in the front part of the brain will receive either the steroid or a placebo for three days. The…

This study tests a drug called sacituzumab in 22 people with a rare and aggressive type of ovarian cancer (clear cell carcinoma) that has worsened after immunotherapy. The drug is an antibody-drug conjugate designed to target and kill cancer cells. The main goal is to see how man…

This phase 2 trial tests whether combining the targeted chemotherapy sacituzumab govitecan with the immunotherapy toripalimab works better than toripalimab plus standard chemotherapy (nab-paclitaxel) for people with advanced triple-negative breast cancer that is PD-L1 positive. A…

This study looks at whether a special ultrasound can accurately detect if breast cancer has completely disappeared from lymph nodes after chemotherapy. About 150 women with cancer that spread to their lymph nodes will have a small clip placed in a cancerous node before treatment.…

This study tests an artificial intelligence (AI) model that uses images from prostate biopsies to predict when prostate cancer will become resistant to hormone therapy. Researchers will enroll 150 patients with intermediate- to high-risk prostate cancer who are starting hormone t…

This study tests a surgical technique done at the same time as breast cancer lymph node removal to prevent arm lymphedema (chronic swelling). The procedure uses a small flap of tissue from the side of the chest to rebuild the armpit area and support fluid drainage. One hundred hi…

This study compares two ways of giving a large-volume subcutaneous injection of targeted therapy (pertuzumab and trastuzumab) to 40 women with HER2-positive breast cancer. Each patient will receive one injection by a nurse using a stopwatch to mimic a steady speed, and another in…

This study tests if a new treatment—mild nerve stimulation on the ear plus personalized music—can reduce the annoyance of chronic tinnitus (ringing in the ears) better than standard therapy. About 386 adults with bothersome tinnitus for at least 6 months will be randomly assigned…

This study will test an artificial intelligence system designed to give early warning of cancer spreading to other parts of the body. Current imaging can only see larger tumors, but this AI analyzes routine scans and patient data to detect signs of microscopic spread. Researchers…

This study looks at whether a color Doppler ultrasound feature called the 'twinkling artifact' can make breast tissue marker clips easier to see. These clips are placed to mark suspicious areas in the breast or lymph nodes. The study will review past images from about 86 women wi…

This study looks at how well immunotherapy shrinks tumors and lymph node metastases in 5,000 people with various cancers. Researchers will track changes in tumor and lymph node size after treatment and explore factors like beta-blocker use that might affect results. The goal is t…

This study looks at whether a clot-dissolving medicine called tenecteplase is safe and effective for people having a stroke when given more than 4.5 hours after symptoms began. Researchers will follow 3000 patients in China to see how many recover with little or no disability aft…

This study will track 3,000 stroke patients in China who received clot-busting medication more than 4.5 hours after their symptoms began. Researchers want to see if this later treatment is still safe and helps reduce disability. The study is observational, meaning it simply watch…