Janssen Research & Development, Llc

This study tested whether a new vaccine called ExPEC9V can prevent serious, invasive E. coli infections in adults aged 60 and older who have had a urinary tract infection in the last two years. Nearly 18,000 participants received either the vaccine or a placebo shot and were foll…

This was a first-in-human study to test the safety and find the right dose of a new oral drug, JNJ-64619178, for people with advanced cancers that have not responded to other treatments. It involved 114 adults with specific advanced solid tumors, non-Hodgkin lymphoma, or a type o…

This study tested an investigational oral medication called JNJ-77242113 for people with moderate-to-severe plaque psoriasis. It involved 255 participants who took different doses of the drug or a placebo for 16 weeks. The main goal was to see how well the drug cleared skin plaqu…

This study tested an experimental drug called M281 (nipocalimab) in pregnant women at high risk for a severe fetal blood disease called HDFN. The goal was to see if the drug could help babies be born alive after 32 weeks of pregnancy without needing risky blood transfusions while…

This study tested a one-time gene therapy injection for people with X-linked retinitis pigmentosa (XLRP), a genetic condition that damages the retina and leads to vision loss. The goal was to see if delivering a corrected gene directly into the eye could slow or stop disease prog…

This study tested whether adding a new daily pill called aticaprant to a person's current antidepressant could better treat major depression, specifically for people who experience a severe lack of pleasure (anhedonia). Over 500 adults who weren't getting enough benefit from thei…

This study tested whether the drug niraparib could help control advanced prostate cancer that had stopped responding to standard hormone therapies and had spread. It specifically enrolled 289 men whose cancer had specific problems with DNA repair, a genetic weakness the drug is d…

This study tested whether adding an experimental drug called nipocalimab to an existing arthritis medication (certolizumab) works better than the existing drug alone. It involved 103 adults with active rheumatoid arthritis whose symptoms weren't controlled by other advanced treat…

This study tested whether an intravenous medication called golimumab could reduce symptoms of active ankylosing spondylitis, a chronic inflammatory disease that causes back pain and stiffness. 208 participants were randomly assigned to receive either the drug or a placebo infusio…

This large, completed Phase 3 study tested whether adding a targeted drug (daratumumab) to a standard two-drug therapy (lenalidomide and dexamethasone) was better at controlling newly diagnosed multiple myeloma. It involved 737 older adults or those ineligible for intensive stem …

This study tested whether an experimental drug called JNJ-77242113 could help adults with moderate-to-severe ulcerative colitis who hadn't responded well to standard treatments. Researchers compared the drug against a placebo in 252 participants over 12 weeks to see if it reduced…

This early-stage study tested a new drug, JNJ-70218902, in men with advanced prostate cancer that had stopped responding to standard treatments. The main goals were to find a safe dose and see how the body handles the drug. The drug works by guiding the patient's own immune cells…

This study tested an intravenous medication called golimumab in children with active polyarticular juvenile idiopathic arthritis who weren't getting enough relief from their current methotrexate treatment. Researchers wanted to understand how the drug moves through the body, how …

This study tested whether a medication called ustekinumab could help children with moderate to severe Crohn's disease get their symptoms under control and stay in remission. It involved 101 young participants who first received the drug through an IV and then through injections. …

This study tested whether an experimental injection into the eye (called JNJ-81201887) could slow the progression of geographic atrophy, a late-stage form of age-related macular degeneration that causes permanent vision loss. It involved 305 participants who received either the r…

This large, completed study tested whether adding an experimental oral medication called milvexian to standard care could better prevent future major heart problems in people who recently had a heart attack or unstable chest pain. Over 14,000 high-risk participants were randomly …

This study tested whether an oral pill called erdafitinib could help people with a specific type of high-risk bladder cancer stay cancer-free longer than standard chemotherapy washes into the bladder. It involved 107 people whose cancer had returned after a common treatment calle…

This study tested the safety of adding a new drug called daratumumab to two existing medications (lenalidomide and dexamethasone) for people with multiple myeloma that had returned after previous treatments. The trial involved 45 participants and aimed to find the safest and most…

This study tested whether the drug guselkumab is safe and effective for treating moderate-to-severe plaque or scalp psoriasis specifically in people with skin of color. It involved 213 participants who identified as non-white or non-Caucasian. The main goal was to see if the drug…

This study tested whether giving two different arthritis drugs together as injections works better than one alone for people with active psoriatic arthritis. It involved 91 adults whose symptoms weren't well-controlled by their previous standard treatments. Researchers compared t…

This study tested whether an experimental drug called nipocalimab could reduce disease activity and symptoms in adults with primary Sjogren's syndrome, an autoimmune condition that causes severe dryness, fatigue, and pain. Researchers compared nipocalimab against a placebo in 163…

This study provided continued access to treatment for people with mantle cell lymphoma that had returned or stopped responding to previous therapies. It compared a combination of ibrutinib and rituximab against other standard drug combinations chosen by doctors. The main goal was…

This study followed 42 adults and children for up to 5 years after they received an experimental gene therapy for a genetic eye disease called X-linked retinitis pigmentosa. The main goal was to check for any long-term safety issues from the treatment. Researchers also tracked wh…

This study tested how well and how safely the medication ustekinumab (brand name STELARA) works for Chinese adults with moderate to severe Crohn's disease. It involved 182 participants who received the treatment for one year. Researchers measured whether the drug reduced gut infl…

This study tested whether an experimental drug called nipocalimab could better control active systemic lupus compared to a placebo. It involved 228 adults with moderate-to-severe lupus who were already on standard treatments. Participants received either the drug or a placebo for…

This was the first human study of a new experimental drug called JNJ-75348780 for people with advanced non-Hodgkin lymphoma or chronic lymphocytic leukemia that has returned or stopped responding to other treatments. The main goals were to find a safe dose and understand the drug…

This large, completed Phase 3 trial tested whether adding a drug called daratumumab to a standard three-drug therapy (CyBorD) works better for people newly diagnosed with AL amyloidosis. AL amyloidosis is a serious disease where abnormal proteins build up and damage organs like t…

This study tested whether adding a new drug called aticaprant to a person's current antidepressant could help improve symptoms in adults with major depression who also experience a severe loss of pleasure (anhedonia) and haven't gotten enough relief from their current medication.…

This was the first study in people to test the safety of a new oral drug called JNJ-74856665 for advanced blood cancers like acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The main goal was to find the highest dose patients could tolerate without severe side ef…

This study tested an investigational oral medication, JNJ-77242113, to see how well it controls moderate-to-severe plaque psoriasis over a longer period. It involved 227 people who had already completed a prior 16-week study with the same drug. The main goal was to measure how ma…

This study aimed to find a new way to detect pulmonary hypertension (PH) earlier using a simple blood test. Researchers analyzed blood samples from 907 people to look for tiny genetic markers (called miRNAs) that might signal the disease. They compared the accuracy of this potent…

This study aimed to better understand the health journey of pregnant women and their babies who are at high risk for a severe blood disease in newborns. Researchers observed the standard medical care and outcomes for 17 participants without testing a new treatment. The goal was t…