New drug duo shows promise for tough lung cancer

NCT ID NCT06532032

Completed Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This completed Phase 1/2 trial tested a combination of two drugs, amivantamab and docetaxel, in 12 people with advanced non-small cell lung cancer that had spread. The goal was to find a safe dose and see if the combo could shrink tumors. The study focused on patients whose cancer had worsened after standard treatments like chemotherapy and immunotherapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Amivantamab and docetaxel
What this could lead to: If successful, this combination could offer a new treatment option for people with advanced non-small cell lung cancer that has stopped responding to standard therapies.
What could go wrong: This is an early-phase trial with only 12 participants, so results may not apply to everyone. Side effects can be serious, including severe toxicity and lung inflammation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG

Contacts and locations

Locations

Ankara Bilkent Sehir Hastanesi

Çankaya, 06800, Turkey (Türkiye)
Cancer and Blood Specialty Clinic

Los Alamitos, California, 90720, United States
Changhua Christian Hospital

Changhua, 500, Taiwan
Chi Mei Medical Center Liu Ying

Liou Ying Township, 736, Taiwan
Hunterdon Hematology Oncology

Flemington, New Jersey, 08822, United States
Kaohsiung Medical University Hospital

Kaohsiung City, 80708, Taiwan
Leeds Teaching Hospitals NHS Trust

Leeds, LS9 7TF, United Kingdom
National Taiwan University Hospital

Taipei, 10043, Taiwan
Oncology Hematology Associates

Springfield, Missouri, 65807, United States
Taichung Veterans General Hospital

Taichung, 40705, Taiwan
Taipei Medical University

Taipei, 110, Taiwan
The Royal Marsden NHS Trust

Sutton, SM2 5PT, United Kingdom
UCI Health Irvine Hospital

Irvine, California, 92612, United States
University of California Irvine Medical Center Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States

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