New drug trial targets root cause of debilitating autoimmune disease

NCT ID NCT04968912

Completed Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

Summary

This study tested whether an experimental drug called nipocalimab could reduce disease activity and symptoms in adults with primary Sjogren's syndrome, an autoimmune condition that causes severe dryness, fatigue, and pain. Researchers compared nipocalimab against a placebo in 163 participants over 24 weeks to see if it could lower disease activity scores and improve patient-reported symptoms. The trial was designed to measure both how well the drug worked and how safe it was for people with this chronic condition.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Altoona Center For Clinical Research

Duncansville, Pennsylvania, 16635, United States
Anniston Medical Clinic

Anniston, Alabama, 36207, United States
Arizona Arthritis & Rheumatology Research, PLLC

Mesa, Arizona, 85210, United States
Arizona Arthritis and Rheumatology Research PLLC

Glendale, Arizona, 85306, United States
Austin Regional Clinic

Austin, Texas, 78731-3146, United States
Azienda Ospedaliera Universitaria Integrata Verona

Verona, 37126, Italy
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone

Palermo, 90129, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia Presidio Spedali Civili

Brescia, 25123, Italy
Bay Area Arthritis and Osteoporosis

Brandon, Florida, 33511, United States
CHRU Hôpital de Hautepierre

Strasbourg, 67098, France
CHU de Grenoble Hopital Albert Michallon

La Tronche, 38700, France
Centre Hospitalier Le Mans

Le Mans, 72037, France
Centre for Rheumatology, Immunology and Arthritis

Fort Lauderdale, Florida, 33309, United States
Centrum Medyczne

Poznan, 61 113, Poland
Centrum Medyczne AMED Targowek

Warsaw, 03 291, Poland
Centrum Medyczne Oporow

Wroclaw, 52 415, Poland
Chang Gung Memorial Hospital Linkou Branch

Taoyuan District, 333, Taiwan
Charite Universitaetsmedizin Berlin

Berlin, 10117, Germany
Clinical Investigation Specialists

Gurnee, Illinois, 60031, United States
Colorado Arthritis Associates

Denver, Colorado, 80228, United States
Columbia Arthritis Center

Columbia, South Carolina, 29204, United States
Corporacio Sanitari Parc Tauli

Sabadell, 08208, Spain
Denver Arthritis Clinic

Denver, Colorado, 80230, United States
Dr. Ramesh Gupta

Memphis, Tennessee, 38119, United States
Erasmus Medisch Centrum

Rotterdam, 3015 GD, Netherlands
Hamburger Rheuma Forschungszentrum II

Hamburg, 20095, Germany
Hokkaido University Hospital

Sapporo, 060-8648, Japan
Hopital Pitie Salpetriere

Paris, 75013, France
Hopital Saint Joseph

Marseille, 13285, France
Hosp Clinico Univ de Salamanca

Salamanca, 37007, Spain
Hosp Reina Sofia

Córdoba, 14004, Spain
Hosp Univ A Coruna

A Coruña, 15006, Spain
Hosp. Infanta Luisa

Seville, 41010, Spain
Hosp. de Merida

Mérida, 6800, Spain
IRCCS Ospedale San Raffaele

Milan, 20132, Italy
Inland Rheumatology Clinical Trials, Inc.

Upland, California, 91786, United States
Instituto Portugues de Reumatologia

Lisbon, 1050-034, Portugal
Malopolskie Badania Kliniczne Sp z o o

Krakow, 30-002, Poland
Medisch Centrum Leeuwarden

Leeuwarden, 8934 AD, Netherlands
Medycyna Kliniczna

Warsaw, 00-874, Poland
Nagasaki University Hospital

Nagasaki, 852-8501, Japan
Narodowy Instytut Geriatrii Reumatologii i Rehabilitacji im prof dr hab med Eleonory Reicher

Warsaw, 02 637, Poland
Nasz Lekarz Przychodnie Medyczne

Bydgoszcz, 85-065, Poland
Nihon University Itabashi Hospital

Tokyo, 173 8610, Japan
North Mississippi Medical Clinics

Tupelo, Mississippi, 38801, United States
Omega Research Consultants

Orlando, Florida, 32835, United States
P.O. Vittorio Emanuele Azienda Ospedaliero Universitaria 'Policlinico Vittorio Emanuele'

Catania, 95100, Italy
PMG Research of Salisbury

Salisbury, North Carolina, 28144, United States
REUMED Zespol Poradni Specjalistycznych Filia nr 2

Lublin, 20-607, Poland
Rheumatology Associates Of South Florida

Boca Raton, Florida, 33486, United States
St. Jude Heritage Medical Group

Fullerton, California, 92835, United States
St. Luke's International Hospital

Tokyo, 104 8560, Japan
St. Paul Rheumatology P A

Eagan, Minnesota, 55121, United States
Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy

Bydgoszcz, 85-168, Poland
Tokyo Metropolitan Tama Medical Center

Fuchū, 183 8524, Japan
Tri-Service General Hospital

Taipei, 11490, Taiwan
Trinity Clinical Research, LLC

Carrollton, Texas, 75007, United States
ULSAM, EPE - Hospital Conde de Bertiandos

Ponte de Lima, 4990-078, Portugal
Uniklinik Köln

Cologne, 50923, Germany
Universitatsklinikum Carl Gustav Carus Dresden

Dresden, 01307, Germany
Universitatsklinikum Tubingen

Tübingen, 72076, Germany
University of Florida Health Jacksonville

Jacksonville, Florida, 32209, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Tsukuba Hospital

Tsukuba, 305-8520, Japan
West Tennessee Research Institute

Jackson, Tennessee, 38305, United States
Zespolu Opieki Zdrowotnej w Konskich

Gmina Końskie, 26 200, Poland
medius KLINIK KIRCHHEIM

Kirchheim unter Teck, 73230, Germany

Conditions

Explore the condition pages connected to this study.

SJOGREN'S SYNDROME