New combo therapy shows promise for Tough-to-Treat rheumatoid arthritis
NCT ID NCT06028438
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether adding nipocalimab to the standard drug certolizumab works better than certolizumab alone for people with active rheumatoid arthritis. It involved 103 adults who still had moderate to severe symptoms despite trying other advanced treatments. The main goal was to see if the combination reduced joint swelling and tenderness more effectively after 12 weeks.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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ARCIS Salud SRL Aprillus asistencia e investigacion
CABA, C1406AGA, Argentina
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Altoona Center For Clinical Research
Duncansville, Pennsylvania, 16635, United States
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Arizona Arthritis and Rheumatology Research PLLC
Phoenix, Arizona, 85032, United States
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Atlanta Research Center for Rheumatology
Marietta, Georgia, 30060, United States
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Bay Area Arthritis and Osteoporosis
Brandon, Florida, 33511, United States
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Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz
Gyula, 5700, Hungary
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Budai Irgalmasrendi Korhaz
Budapest, H-1027, Hungary
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CMed Rehabilitacios es Diagnosztikai Kozpont
Székesfehérvár, 8000, Hungary
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Centro Privado de Medicina Familiar
Buenos Aires, C1417, Argentina
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Centro de Investigaciones Medicas Tucuman
San Miguel de Tucumán, T4000AXL, Argentina
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Centrum Medyczne Reuma Park
Warsaw, 02 665, Poland
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Clinical Research of West Florida
Clearwater, Florida, 33765, United States
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Graves Gilbert Clinic
Bowling Green, Kentucky, 42101, United States
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Hamburger Rheuma Forschungszentrum II
Hamburg, 20095, Germany
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Hospital Central Militar Cirujano Mayor Dr Cosme Argerich
Buenos Aires, C1426BOR, Argentina
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Inland Rheumatology Clinical Trials Inc.
Upland, California, 91786, United States
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Integral Rheumatology And Immunology Specialists
Plantation, Florida, 33324, United States
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Kings College Hospital
London, SE5 9RS, United Kingdom
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MICS Centrum Medyczne Warszawa
Warsaw, 00 874, Poland
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Mautalen Salud e Investigacion
CABA, C1128AAF, Argentina
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Medway NHS Foundation Trust
Gillingham, ME7 5NY, United Kingdom
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NZOZ Lecznica MAK MED S C
Nadarzyn, 05 830, Poland
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Newport Huntington Medical Group
Huntington Beach, California, 92648, United States
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Porcika Klinika - Vasarhelyi Sarkanyfu Kft.
Hódmezővásárhely, 6800, Hungary
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Rheumazentrum Ratingen
Ratingen, 40878, Germany
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Rheumazentrum Ruhrgebiet
Herne, 44649, Germany
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STAT Research S A
Buenos Aires, C1023AAB, Argentina
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Sanatorio Agote
Buenos Aires, C1425EOE, Argentina
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Southwest Rheumatology Research LLC
Mesquite, Texas, 75150, United States
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Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy
Bydgoszcz, 85-168, Poland
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Vital Medical Center Orvosi es Fogaszati Kozpont
Veszprém, 8200, Hungary
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Western General Hospital
Edinburgh, EH4 2XU, United Kingdom
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Other studies related to the condition(s) this trial covers.
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