Centre Hospitalier De L'université De Montréal (chum)

This study tests whether a special probiotic supplement can change fat-related molecules in the blood of people with ALS and frontotemporal dementia (FTD). Researchers will compare those taking the probiotic to those taking a placebo over 24 weeks. The goal is to see if the probi…

This study tests a method to make cornea grafts stronger before they are used as a support for the Boston keratoprosthesis type I, an artificial cornea. The goal is to see if strengthening the graft with a special light and vitamin treatment (crosslinking) can prevent the graft f…

This study tests whether giving a laser treatment (transscleral cyclophotocoagulation) to lower eye pressure before a Boston keratoprosthesis (a plastic cornea implant) can prevent or slow glaucoma. Twenty adults who need the implant will receive one of two laser types 4-8 weeks …

This study tests whether adding targeted radiation to spots where prostate cancer has spread can help men whose cancer is already responding to hormone therapy. About 80 men with metastatic prostate cancer will be randomly assigned to get either standard care or standard care plu…

This study looks at whether giving a blood thinner called heparin through a vein can improve the chances that a reattached finger will survive after a traumatic amputation. About 188 adults who have had finger reattachment surgery will be split into two groups: one gets heparin, …

This study looks at whether giving a high-dose prescription stimulant (lisdexamfetamine) for 25 weeks is feasible and acceptable for people with moderate to severe methamphetamine use disorder. About 80 participants will receive either the drug or a placebo alongside their usual …

This study looks at whether giving radiation to the chest after surgery and chemo-immunotherapy can help people with stage III non-small cell lung cancer who still have signs of cancer after treatment. About 118 adults will be randomly assigned to receive or not receive radiation…

This study tests whether adding a high-dose stimulant medication and/or a reward-based program (contingency management) to standard care helps people reduce how often they use methamphetamine. About 440 adults with moderate to severe methamphetamine use disorder will be randomly …

This study compares two ways of using a heart-lung support machine (ECMO) during lung transplants: using it routinely for all patients versus using it only when problems arise. About 218 adults with end-stage lung disease will take part. The goal is to see which approach leads to…

This study tests whether adding the drug fostemsavir to standard HIV treatment can lower the risk of heart disease in people with well-controlled HIV. Researchers will compare heart imaging and blood tests between 150 adults who get the extra drug and those who don't. Participant…

This study tests a new care coordination system called PRONTO-HN for head and neck cancer patients. The system uses a risk model to identify patients likely to need radiation after surgery and then coordinates appointments and alerts to reduce delays. Researchers will compare 85 …

This study tests whether a new type of ultrasound, called quantitative ultrasound (QUS), can find liver cancers that standard ultrasound often misses. About 328 adults at risk for liver cancer will receive both QUS and standard ultrasound, and results will be compared to MRI or b…

This study tests a new method to find air leaks in the lungs during surgery. Doctors blow a visible glycerine smoke into the lungs, and the smoke escapes through any leaks, making them easy to spot. The goal is to reduce complications and hospital stays for 200 lung transplant pa…

This study is testing whether combining a special PET scan (PSMA-PET) with artificial intelligence can help predict how prostate cancer will behave. Researchers will scan 1,000 men with prostate cancer and use deep learning to find patterns in the images that link to survival and…

This study uses donated human lungs to test a new method for detecting and sealing air leaks that can happen during lung surgery. Researchers will place the lungs in a special box, keep them warm, and use a video camera and a bio-adhesive to find and fix leaks. The goal is to red…

This study is testing whether a special PET scan using F-choline can help doctors find and diagnose certain cancers and other medical conditions more accurately. Researchers will enroll 500 adults with known or suspected conditions where this scan might provide useful information…

This study tests a portable device that uses electrical signals to detect early fluid buildup in the lungs of heart failure patients. The goal is to see if it works as well as standard imaging methods like ultrasound. If successful, this device could help patients manage their co…

This study is testing whether a special anti-inflammatory eye drop (infliximab) can prevent glaucoma after a cornea transplant. About 50 adults having their first cornea transplant will use the drops after surgery. Researchers will watch for side effects and check if the drops he…

This study tests whether adding a drug called aprepitant to standard nausea prevention can help high-risk patients avoid vomiting and nausea after outpatient surgery. About 260 adults at high risk for postoperative sickness will take either aprepitant or a placebo before surgery.…

This study is testing a French-language iPhone app called Joint Effort 2.0 that gives personalized feedback and tips to help cannabis users adopt safer habits. About 110 adult cannabis users in Quebec will use the app for a period and report how often they use protective strategi…

This study looks at a procedure called EUS-guided celiac plexus neurolysis (EUS-CPN) to help manage pain from pancreatic cancer. Doctors usually inject a numbing drug (bupivacaine) before alcohol to prevent pain, but it's unclear if it helps or might even reduce the procedure's e…

This early-stage study tests a new drug called KAN-004 in 21 adults who have diarrhea or colon inflammation from cancer immunotherapy. The main goal is to see if the drug is safe and tolerable. Participants must have a solid tumor and be at least 18 years old.

This study explores whether adding Acceptance and Commitment Therapy (ACT) to ketamine treatment is practical for 30 adults who have both alcohol use disorder and treatment-resistant depression. Participants will receive weekly ketamine infusions and ACT sessions for 8 weeks. The…

This study compares three robotic-assisted surgery methods for lung removal to see which causes the least chronic pain. 120 adults having lung surgery will be followed for 6 months. The goal is to find a technique that reduces nerve damage and long-term chest pain.

This study tests whether trazodone, a medication often used for depression, can improve sleep in adults aged 65 and older with chronic insomnia. Forty participants will take either trazodone or a placebo for 28 days, then switch after a break. They will track their sleep with dia…

This study collects tear samples from 300 people with dry eye, infectious keratoconjunctivitis, mucous membrane pemphigoid, or allergic conjunctivitis. Researchers will analyze the proteins and metabolites in tears to create a unique fingerprint for each condition. The goal is to…

This study tests a new device called STING-MARK that helps doctors mark the exact location of a tumor for image-guided treatments. Researchers will use donated organ samples (not live patients) to see if the marker is easy to place, stays in place, and shows up clearly on scans. …

This study follows 15,000 adults aged 45+ (or 65+ without risk factors) who are having same-day noncardiac surgery. The goal is to learn how often heart problems and other complications happen after these surgeries, and to create tools that help doctors predict and reduce risks. …

This study uses donated human lungs to develop a standard method for a new freezing catheter that can take tissue samples (biopsy) and destroy abnormal tissue (ablation). Researchers will test different freezing times and temperatures to find the safest and most effective techniq…

This study checks the safety of a radioactive substance called N-13 ammonia, made at the hospital's own lab, for use in heart scans. About 20,000 adults who need a heart scan will receive this substance and be watched for any side effects. The goal is to make sure the substance i…

This study tests three different methods of numbing the chest (paravertebral block) to see which provides the best pain relief after video-assisted lung surgery. Researchers will check how much sensation is lost in the chest area using ice and a special filament. The goal is to f…

This study will measure how many women at a high-risk pregnancy clinic experience postpartum depression. Researchers will use a standard questionnaire called the Edinburgh Postnatal Depression Scale (EPDS) to screen 100 women who gave birth 4 weeks to 6 months ago. The goal is to…

This study tests a special method of removing the breathing tube after abdominal surgery to prevent lung problems. It involves 270 adults at moderate or high risk of lung complications. The goal is to see if a protective extubation approach is practical and followed correctly by …

This study aims to understand how young adults aged 18-24 use cannabis in their everyday lives. Over 350 regular users will report their consumption patterns, product types, and experiences through a mobile app for two years. The goal is to identify different use patterns and how…

This study tests whether a low-methionine diet can change the gut microbiome and reduce inflammation in 40 healthy adults. Participants follow a plant-based, low-methionine diet for several weeks, with some also taking methionine supplements or a placebo. Researchers will measure…

This study is testing whether different doses of cannabidiol (CBD) can reduce the psychoactive effects of THC in healthy adults who use cannabis occasionally. One hundred participants will inhale various combinations of CBD and THC and report their experiences. The goal is to fin…

This pilot study is testing a new ultrasound tool that measures how much the lungs stretch (strain) in patients on breathing machines in the ICU. The goal is to collect initial data from 10 adults with lung disease to see if this technique can help doctors better monitor and prev…