Centre Hospitalier De L'université De Montréal (chum)

This study aims to determine the best way to use a heart-lung machine (called ECMO) during lung transplant surgery. Researchers will compare using the machine for every patient versus only using it when problems arise during surgery. The goal is to see which approach helps patien…

This study is testing whether adding a specific type of talk therapy (Acceptance and Commitment Therapy) to ketamine treatment is a practical and helpful approach for people struggling with both alcohol use disorder and depression that hasn't responded to other treatments. It wil…

This study is testing whether adding radiation therapy after chemotherapy, immunotherapy, and surgery helps patients with stage III non-small cell lung cancer who still have some cancer cells left. It will compare survival and cancer control between patients who receive the extra…

This study is testing whether adding a medication called fostemsavir to standard HIV treatment can lower the risk of heart disease in people whose HIV is already well-controlled. Researchers will compare heart scans, physical tests, and blood markers over two years between 150 pa…

This study is testing whether people with moderate to severe methamphetamine addiction can safely take a high-dose stimulant medication for 25 weeks alongside standard treatment. Researchers want to see if participants stay in the program, take their medication regularly, and are…

This study is testing two different approaches to managing fluids given during liver transplant surgery. One approach uses less fluid overall, while the other uses more fluid to keep the heart pumping strongly. The goal is to see which method helps patients recover better after s…

This study is testing if a specific 'open lung' technique for removing the breathing tube after abdominal surgery can reduce lung complications like pneumonia or collapsed lung. It will involve 270 adults at high risk for these problems. The main goal is to see if running this la…

This study is testing if adding a high-dose stimulant medication and a reward-based program to standard addiction treatment helps adults with methamphetamine use disorder reduce their drug use. Researchers will compare four different combinations of these approaches over 15 weeks…

This study is testing a new hospital coordination system designed to help patients with head and neck cancer start their follow-up radiation therapy faster after surgery. Long delays between surgery and radiation are common and linked to worse outcomes. The system uses automated …

This study is testing a new system that uses glycerine smoke to find air leaks in lungs during surgery. Air leaks are common complications after lung operations that can lead to longer hospital stays. The system creates visible smoke that flows through any leaks, helping surgeons…

This study is testing a new portable device that measures chest electrical signals to detect early fluid buildup in the lungs of people with heart failure. Researchers want to see if the device's readings match those from standard lung ultrasounds and CT scans. If accurate, this …

This study aims to see if artificial intelligence (AI) can analyze a new, highly sensitive type of PET scan to predict how prostate cancer will progress and how patients will respond to treatment. It will enroll 1000 patients at a Montreal hospital who are already scheduled for t…

This study is checking the safety of a radioactive tracer called N-13 ammonia used during advanced heart imaging scans. The tracer helps doctors see blood flow to the heart more clearly than older methods. Researchers will monitor 20,000 patients for any side effects after receiv…

This study is testing new, advanced ultrasound techniques to improve the detection and diagnosis of liver cancer. It aims to see if these new methods can find small tumors that standard ultrasound often misses, especially in patients at high risk. Finding cancer earlier is critic…

This study is testing if adding a medication called aprepitant to the standard prevention plan works better to stop nausea and vomiting after outpatient surgery. It will involve 260 adults who are at high risk for these side effects. The main goal is to see if patients who get th…

This study is testing if the medication trazodone is better than a placebo at reducing insomnia symptoms in adults aged 65 and older. Participants will take either trazodone or a placebo pill for 28 days, then switch to the other option after a break. Researchers will measure cha…

This study compares three different robotic surgery techniques for removing lung tumors to see which causes less long-term pain. Researchers are testing whether avoiding putting instruments between the ribs reduces nerve damage and chronic pain that often follows these operations…

This study aims to find the best way to numb the chest wall after minimally invasive lung surgery to control pain. Researchers will compare three different techniques for placing a nerve block in 90 patients. The goal is to understand why current pain relief sometimes falls short…

This research aims to develop better methods to find and fix air leaks that can happen during lung surgery. Researchers will use donated human lungs that are not suitable for transplant to create a realistic lab model. They will test a new bio-adhesive sealant to see if it can ef…

This study aims to understand how often heart problems and other complications happen after same-day outpatient surgery. It will follow 15,000 adults for 90 days after their procedure to identify risk factors and create better tools to predict which patients are safest for this t…

This small pilot study aims to test a new ultrasound tool that measures strain on the lungs of critically ill patients who are on breathing machines. The goal is to gather initial data to see if this tool can help doctors detect when a patient's lungs are being overstretched by t…

This study aims to understand if taking cannabidiol (CBD) changes the mind-altering effects of tetrahydrocannabinol (THC), the main psychoactive part of cannabis. Researchers will recruit 100 healthy, occasional cannabis users to inhale different combinations of CBD and THC. They…

This study aims to develop a better, standardized technique for using freezing catheters to take lung tissue samples and treat lung lesions. Researchers will test the procedure on donated human lungs to see if it can be a safer, less invasive alternative to current surgical metho…

This study aims to understand how young adults (ages 18-24) use cannabis in their daily lives. Researchers will follow 350 regular cannabis users for two years, tracking what products they use, how much, and how often through a mobile app. The goal is to identify different patter…

This study aims to find out how common postpartum depression is among new mothers visiting a high-risk pregnancy clinic. Researchers will test a simple screening questionnaire during routine check-ups to identify mothers who may need mental health support. The goal is to see if t…

This study is testing whether a specific diet low in the nutrient methionine can change the bacteria in your gut and reduce inflammation in the body. It involves 40 healthy adults who will follow the special diet for short periods while researchers check their stool, blood, and i…