Bayer

This study tested the drug larotrectinib in 215 adults with various solid cancers that have a specific change in the NTRK gene. The drug is taken orally and works by blocking the action of the altered gene. The main goal was to see how many patients had their tumors shrink or dis…

This study tests whether adding darolutamide to standard hormone therapy (ADT) helps Chinese men with a high-risk form of prostate cancer that has not spread but is no longer responding to hormone therapy alone. Darolutamide blocks the effects of male hormones on cancer cells, po…

This study tested a higher dose (8 mg) of the drug aflibercept against the standard dose (2 mg) in 892 adults with macular edema from a blocked retinal vein. The goal was to see if the higher dose works as well or better while allowing fewer injections. Participants received inje…

This study tested a new drug called BAY3283142 in 75 people with mild to moderate high blood pressure. The drug is designed to relax blood vessels and is being developed for chronic kidney disease. Participants took different doses or a placebo for up to 10 weeks to check for saf…

This study tested a new drug called BAY 3283142 in 1222 adults with chronic kidney disease and high protein in their urine. Participants took either the drug or a placebo on top of their usual treatments for 16 weeks. The goal was to see if the drug could lower urine albumin leve…

This study tested whether a higher dose (8 mg) of the drug aflibercept, given every 16 weeks, works as well as the standard dose (2 mg) given every 8 weeks for Chinese people with diabetic macular edema (DME), a diabetes-related eye condition that causes vision problems. 333 part…

This study tested two drugs, darolutamide and enzalutamide, in 28 men with prostate cancer that had returned after initial treatment. The goal was to see how each drug affects testosterone levels and side effects like breast tenderness. Darolutamide may cause fewer of these side …

This study tested whether adding darolutamide to standard hormone therapy helps men with prostate cancer that has spread to other parts of the body. 669 men participated. The goal was to see if the combination delays cancer growth or death. Results showed improvement in progressi…

This study tested a radioactive drug called radium-223 in 921 men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The goal was to see if it helps them live longer and controls the cancer. Participants received either the drug …

This study tested a drug called finerenone in about 1,580 adults with chronic kidney disease not caused by diabetes. The goal was to see if adding finerenone to standard care could slow kidney function decline better than a placebo. Participants took the drug or placebo daily for…

This study tested a new pill called larotrectinib in 75 adults with advanced cancers that have a specific gene change (NTRK fusion). The main goals were to check the drug's safety, find the best dose, and see how the body processes it. Participants had no other good treatment opt…

This study collected data from 2,400 adults in China with chronic heart failure to see how well the drug vericiguat works compared to standard treatments. Researchers tracked deaths, hospital stays, and side effects over 12 months. The goal is to understand if vericiguat helps co…

This study tested a drug called BAY 3018250 in 258 people with deep vein thrombosis (DVT), a condition where blood clots form in deep leg veins. The drug is designed to dissolve clots, unlike standard blood thinners that only prevent clots from growing. Researchers compared two d…

This study tested the safety of Jivi (BAY 94-9027), a longer-lasting clotting factor, in 36 children aged 7 to 12 with severe hemophilia A. The medicine is already approved for older patients, but this trial focused on younger kids to check for allergic reactions and whether the …

This Phase 3 study tested whether adding darolutamide to standard hormone therapy and chemotherapy helps men with metastatic hormone-sensitive prostate cancer live longer. Over 1,300 participants received either darolutamide or a placebo, along with standard treatments. The main …

This study tested a new scoring method to help doctors choose the best dosing schedule of Jivi (a longer-lasting clotting factor) for people with hemophilia A. 21 participants switched from standard treatments to Jivi, and their dose frequency was based on their personal risk sco…

This completed Phase 4 study tested how much of the drug aflibercept gets into the bloodstream when a high dose (8 mg) is injected into both eyes of adults with diabetic macular edema or wet age-related macular degeneration. Fifty-one participants received the injections and had …

This study looked at how safe and effective Kovaltry is for people with hemophilia A when used in routine medical practice. Researchers tracked 230 patients for side effects and bleeding episodes. The goal was to gather real-world information, not to test a new treatment.

This Phase 3 trial tested whether finerenone, a drug already approved for kidney disease in type 2 diabetes, can also slow kidney damage in people with type 1 diabetes. 241 adults with both conditions took either finerenone or a placebo for 6 months, alongside their usual care. R…

This early-phase study tested a new drug called BAY 2862789 in 45 people with advanced solid tumors, including non-small cell lung cancer. The drug works by activating immune cells to fight cancer. The main goals were to check safety, find the best dose, and see how the drug move…

This Phase 3 trial tested whether adding the targeted drug copanlisib to the standard antibody rituximab helps people with relapsed indolent B-cell non-Hodgkin's lymphoma live longer without their cancer getting worse. The study included 458 adults who had already received at lea…

This study looked at the long-term safety of the drug riociguat (Adempas) in adults with pulmonary arterial hypertension (PAH), a type of high blood pressure in the lungs. It included 18 people who had already taken riociguat in earlier Bayer studies. The main goal was to track s…

This study tested whether starting the heart failure drug vericiguat at a 5 mg dose (instead of the usual 2.5 mg) is safe and tolerable. 106 adults with chronic heart failure with reduced ejection fraction took the 5 mg tablet daily for about two weeks. The goal was to see if ski…

This study looked at data from 500 people in Germany who started taking vericiguat for chronic heart failure with reduced ejection fraction. Researchers wanted to see how well the drug works outside of clinical trials, in routine medical care. They tracked deaths and hospitalizat…

This study tested the safety of aflibercept, an already-approved eye injection, in 100 Indian adults with diabetic macular edema (DME). Participants received injections every 4 weeks for 5 months, then every 8 weeks for a total of 48 weeks. The main goal was to track any side eff…

This study tested a new contrast agent called gadoquatrane for MRI scans of the body (excluding the brain and spine). The goal was to see if using a lower dose of gadolinium could still produce clear images. 404 adults with known or suspected health issues received two MRI scans:…

This study tested a new daily pill called asundexian in over 12,000 people who recently had a stroke or mini-stroke caused by a blood clot from outside the heart. The goal was to see if adding asundexian to standard antiplatelet therapy could prevent another stroke without increa…

This study tested a gel form of the common decongestant oxymetazoline (found in many nasal sprays) in 120 healthy adults with a stuffy nose from colds or allergies. The gel is designed to stay in the nose longer than a spray. Researchers measured how well a single dose relieved c…

This study tested a drug called elinzanetant in 396 postmenopausal women with hot flashes. Participants took either the drug or a placebo daily for up to 26 weeks. The goal was to see if elinzanetant could reduce how often and how severe hot flashes are. Results showed a meaningf…

This study tested a new medicine called elinzanetant for treating hot flashes in women after menopause. About 400 women took either the drug or a placebo daily for up to 26 weeks. The goal was to see if the drug reduces how often and how severe hot flashes are, using daily diarie…

This study tested a daily pill called elinzanetant for treating hot flashes in 628 postmenopausal women. The drug blocks a protein thought to trigger hot flashes. Participants took either elinzanetant or a placebo for 52 weeks and recorded their hot flashes in a diary. The main g…

This study tests a new drug called elinzanetant to see if it can reduce nighttime waking in menopausal women. About 110 women will take either the drug or a placebo for 12 weeks. Researchers will measure sleep quality using sleep tests and diaries.

This study tested a single acyclovir tablet that sticks to the gum to treat cold sores (herpes labialis) in 2020 adults with frequent outbreaks. Participants applied the tablet or a placebo at home and tracked healing over 14 days. The goal was to see if the drug shortens the tim…

This observational study looks at how women treated their menopause hot flashes before and after taking part in earlier clinical trials for the drug elizanetant. Researchers will survey participants and review their medical records to see which treatments they used, whether they …

This early-stage study tested a new drug called BAY 3389934 in 16 healthy Japanese adults to see if it is safe and how the body handles it. The drug is being developed to treat a serious blood clotting condition that can happen with severe infections (sepsis). Participants receiv…

This study followed 990 women who chose either Essure or laparoscopic sterilization to compare rates of pain, abnormal bleeding, allergic reactions, and the need for further surgery. Researchers collected blood samples and tracked health outcomes over time. The goal was to better…

This study examined 150 adults with sepsis in the ICU to find blood markers that signal when the condition turns into a dangerous clotting problem called DIC. Researchers collected blood samples and hospital data over up to 56 days, but did not test any new treatments. The goal i…

This study looks at data from children under 18 in Japan who were prescribed either rivaroxaban or warfarin for blood clots. Researchers want to see how often major bleeding happens in real-world use. No new treatments are given—only existing medical records are reviewed.

This completed study analyzed electronic health records from over 6,500 patients in China who started taking finerenone for chronic kidney disease and type 2 diabetes. Researchers tracked kidney function, potassium levels, and side effects like high potassium. The goal was to see…

This study looked at data from 348 people with type 2 diabetes in Germany who use the myTherapy app. Researchers wanted to see how many had high levels of a protein called albumin in their urine, which is a sign of kidney damage. They also tracked how these levels changed over a …

This study looked at the safety of the blood thinner rivaroxaban in 1500 Japanese patients with peripheral arterial disease (PAD) who had surgery to improve blood flow in their legs. Researchers used existing health records to track bleeding events and heart-related deaths. No ne…

This study reviewed medical records of over 640,000 people in the US who had acute respiratory distress syndrome (ARDS) and were in the ICU. Researchers wanted to find out what new health problems—physical, mental, or emotional—arise after such a stay, known as post-intensive car…

This study looks at data from 121 people with metastatic colorectal cancer who received two approved treatments—regorafenib and TAS (with or without bevacizumab)—in different orders. Researchers want to see which sequence works better and how long patients live. Since this is an …

This study looks at how moderate liver problems change the way the body handles sevabertinib, an experimental cancer drug for tumors with HER2 mutations. About 20 people—10 with liver impairment and 10 healthy volunteers—will take a single dose and have their blood levels measure…

This early-stage study tested how well new tablet versions of the drug elinzanetant are absorbed by the body compared to the original soft gel capsule. Eighteen healthy women took single and multiple doses of each form. The goal was to see if the new pills deliver the same amount…

This study looked at health records from over 5,700 adults in Japan with sepsis (blood poisoning) to see how many also developed a serious blood clotting disorder called DIC. Researchers collected information from hospital databases to track DIC rates and severity scores. The goa…

This study looked at sleep disturbances in 750 women going through menopause. Researchers collected data from health records, questionnaires, and smartwatches to understand how often women wake up at night and how it affects their quality of life. The goal was to learn more about…

This completed observational study examined the real-world use of two approved drugs, regorafenib and TAS-102 (sometimes with bevacizumab), in 818 adults with metastatic colorectal cancer that had stopped responding to other treatments. Researchers analyzed electronic health reco…

This study followed over 1,400 men with metastatic castration-resistant prostate cancer who were already receiving Radium-223 as part of their routine care. Researchers tracked serious side effects and the development of new cancers over several years. The goal was to better unde…

This study followed about 100 babies who were treated for retinopathy of prematurity (ROP) with either Eylea injections or laser therapy in an earlier trial. Researchers checked their vision and eye health years later to see how well the treatments held up. The goal is to underst…

This study analyzed data from nearly 5,000 Japanese patients with chronic heart failure who started taking vericiguat as part of their regular care. Researchers tracked outcomes like hospital stays and deaths over one year to see how the drug performs in everyday practice. The go…

This study looked at how the drug radium-223 spreads in the bones of men with prostate cancer that has spread to bones. Researchers gave the drug intravenously every 4 weeks for up to 6 doses and used imaging scans to measure its distribution in both tumor and healthy bone. The g…

This study followed 1,500 women in higher-income countries who chose to take multivitamins or folic acid before or during pregnancy. Researchers tracked pregnancy outcomes like full-term birth, anemia, preeclampsia, and baby birth weight. The goal is to gather real-world data on …