Which drug first? Real-World study aims to optimize colorectal cancer treatment sequence
NCT ID NCT05839951
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed observational study examined the real-world use of two approved drugs, regorafenib and TAS-102 (sometimes with bevacizumab), in 818 adults with metastatic colorectal cancer that had stopped responding to other treatments. Researchers analyzed electronic health records to see how the order of these drugs affected treatment duration, side effects, and survival. The goal is to provide practical guidance for doctors on the best sequence to use in everyday practice.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Regorafenib, TAS-102 (trifluridine/tipiracil), and bevacizumab
What this could lead to
If successful, this study could help doctors choose the best order of these approved drugs for people with advanced colorectal cancer, potentially improving survival and quality of life.
What could go wrong
This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by patient differences and real-world variability.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Many locations
Whippany, New Jersey, 07981, United States