Can a targeted drug keep working after cancer progresses? new trial aims to find out

NCT ID NCT07389265

Recruiting now Disease control Sponsor: University of Campania Luigi Vanvitelli Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether continuing cetuximab (a targeted antibody) with chemotherapy after first-line treatment stops working can improve outcomes in metastatic colorectal cancer. About 480 adults whose tumors have specific genetic markers (RAS and BRAF wild-type) will receive either cetuximab plus chemo or bevacizumab plus chemo. The study measures tumor response, survival, and safety, with regular scans and blood tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cetuximab (Erbitux) combined with chemotherapy
What this could lead to: If successful, this could show that continuing cetuximab beyond initial progression helps control metastatic colorectal cancer better than switching to a different drug.
What could go wrong: This is a Phase 3 trial, but results may not confirm a benefit. The treatment involves chemotherapy side effects and requires ongoing medication, not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC COLORECTAL CANCER (MCRC)

Contacts and locations

Locations

A.O. 'Pia Fondazione Cardinale G.Panico'
NOT_YET_RECRUITING

Tricase, Italy
A.O.U. Careggi
NOT_YET_RECRUITING

Florence, Italy
A.O.U. Federico II
NOT_YET_RECRUITING

Naples, Italy
A.O.U. Ospedali Riuniti
NOT_YET_RECRUITING

Ancona, Italy
A.O.U. Pisana
NOT_YET_RECRUITING

Pisa, Italy
A.O.U. Sassari
NOT_YET_RECRUITING

Sassari, Italy
A.O.U. dell'Università degli studi della Campania 'Luigi Vanvitelli'
RECRUITING

Naples, Italy
AORN S. Giuseppe Moscati
NOT_YET_RECRUITING

Avellino, Italy
ARNAS Civico - Di Cristina-Benfratelli - P. O. 'Civico e Benfratelli'
NOT_YET_RECRUITING

Palermo, Italy
ASST Grande Ospedale Metropolitano Niguarda
NOT_YET_RECRUITING

Milan, Italy
Azienda Ospedaliero-Universitaria Renato Dulbecco
NOT_YET_RECRUITING

Catanzaro, Italy
Azienda USL IRCCS di Reggio Emilia
NOT_YET_RECRUITING

Reggio Emilia, Italy
Casa di Cura Villa Maria
NOT_YET_RECRUITING

Mirabella Eclano, Italy
Casa di cura Macchiarella
NOT_YET_RECRUITING

Palermo, Italy
Centro di Riferimento Oncologico (C.R.O.) IRCCS
NOT_YET_RECRUITING

Aviano, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
NOT_YET_RECRUITING

Milan, Italy
Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza
NOT_YET_RECRUITING

San Giovanni Rotondo, Italy
Fondazione Poliambulanza Istituto Ospedaliero
NOT_YET_RECRUITING

Brescia, Italy
Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS
NOT_YET_RECRUITING

Roma, Italy
Hospital General Universitario Santa Lucía
NOT_YET_RECRUITING

Cartagena, Spain
Hospital Universitari Vall d´Hebron
NOT_YET_RECRUITING

Barcelona, Spain
Hospital Universitario 12 de Octubre
NOT_YET_RECRUITING

Madrid, Spain
Hospital Universitario Gregorio Marañón
NOT_YET_RECRUITING

Madrid, Spain
Hospital Universitario Marqués de Valdecilla
NOT_YET_RECRUITING

Santander, Spain
Hospital Universitario Regional de Málaga
NOT_YET_RECRUITING

Málaga, Spain
Hospital Universitario Reina Sofía
NOT_YET_RECRUITING

Córdoba, Spain
Hospital Universitario Virgen de las Nieves
NOT_YET_RECRUITING

Granada, Spain
Hospital Universitario de Navarra
NOT_YET_RECRUITING

Pamplona, Spain
Hospital del Mar
NOT_YET_RECRUITING

Barcelona, Spain
IRCCS I.N.T. 'Fondazione G. Pascale'
NOT_YET_RECRUITING

Naples, Italy
IRCCS Istituto Tumori "Giovanni Paolo II"
NOT_YET_RECRUITING

Bari, Italy
IRCCS Istituto clinico Humanitas
NOT_YET_RECRUITING

Rozzano, Italy
IRCCS Ospedale Sacro Cuore Don Calabria
NOT_YET_RECRUITING

Veneto, Italy
Instituto Catalán de Oncología. Hospital Duran i Reynals
NOT_YET_RECRUITING

L'Hospitalet de Llobregat, Spain
Istituto Europeo di Oncologia
NOT_YET_RECRUITING

Milan, Italy
Istituto Oncologico Veneto IRCCS
NOT_YET_RECRUITING

Padova, Italy
Istituto Romagnolo per lo Studio dei Tumori 'Dino Amadori'
NOT_YET_RECRUITING

Meldola, Italy
Nome EnteA.R.N.A.S. Garibaldi - P.O. Garibaldi-Nesima
NOT_YET_RECRUITING

Catania, Italy
Ospedale IRCCS 'Saverio de Bellis'
NOT_YET_RECRUITING

Castellana Grotte, Italy
Ospedale San Giuseppe Moscati
NOT_YET_RECRUITING

Statte, Italy
P.O. 'Vito Fazzi'
NOT_YET_RECRUITING

Lecce, Italy

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