New drug may cause fewer side effects than standard prostate cancer treatment

NCT ID NCT05526248

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 29 times

Summary

This study looked at two drugs, darolutamide and enzalutamide, in men with prostate cancer that had come back after initial treatment but had not yet been treated with hormone therapy. The goal was to see how each drug affects testosterone levels and side effects like breast tenderness. 28 men took part, first all receiving darolutamide, then some switched to enzalutamide for comparison. The study aimed to find out if darolutamide causes fewer hormone-related side effects.

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Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center - Oncology

    Boston, Massachusetts, 02215, United States

  • Central Ohio Urology Group - Gahanna

    Gahanna, Ohio, 43230, United States

  • Mass General Cancer Center

    Boston, Massachusetts, 02114-2696, United States

  • Memorial Sloan Kettering Cancer Center New York - Main Campus

    New York, New York, 10065, United States

  • Unio Specialty Care - Urology - Sherman Oaks

    Sherman Oaks, California, 91411, United States

Conditions

Explore the condition pages connected to this study.