Bayer

This study is testing whether adding a drug called darolutamide to standard hormone therapy works better than hormone therapy alone for men whose prostate cancer has spread. Researchers want to see if this combination helps patients live longer without their cancer getting worse.…

This early-stage study is testing a one-time gene therapy called BAY2599023 (DTX201) for adults with severe hemophilia A. The therapy uses a modified virus to deliver a healthy copy of the gene needed to make clotting Factor VIII, with the goal of helping the body produce this pr…

This study is testing a drug called aficamten in Japanese adults with a heart condition where the heart muscle thickens, making it hard to pump blood and causing symptoms like shortness of breath. The main goal is to see if taking aficamten daily for 6 months improves blood flow …

This study allows cancer patients who are already taking regorafenib in other Bayer studies to continue their treatment if it's working for them. Researchers want to understand how safe and tolerable the continued treatment is for people with solid tumors. The study includes 13 p…

This study compares two different approaches for men whose prostate cancer has spread to their bones and has stopped responding to one type of hormone therapy. Participants will receive either a radioactive drug (Radium-223) given by injection, which targets cancer cells in the b…

This early-stage study is testing a new oral immunotherapy drug called BAY2965501 in people with advanced solid tumors that have spread and are hard to treat. Researchers want to find the safest dose and see how the body handles the drug, both alone and combined with other cancer…

This study observes men with prostate cancer that hasn't spread but has stopped responding to standard hormone therapy. It tracks their experience after their doctor has already decided to treat them with the drug darolutamide. The main goal is to understand the drug's real-world…

This study is observing how a kidney-protecting drug called finerenone is used and how safe it is for patients with chronic kidney disease and type 2 diabetes in real-world Chinese hospitals. It will track 5,000 patients' health records to see how their kidney function and potass…

This study is testing if a higher dose (8 mg) of an eye injection called aflibercept can treat diabetic macular edema (DME) as effectively as the standard lower dose (2 mg), but with fewer injections needed. About 333 Chinese adults with DME will receive injections either every 8…

This study aims to monitor the long-term safety of Jivi, an approved medication for hemophilia A, over at least four years. It will follow 62 patients who are already receiving Jivi regularly to prevent bleeding episodes. Researchers will collect health data during patients' rout…

This study is collecting real-world health records from 150,000 people in the US who have both chronic kidney disease and Type 2 diabetes. Researchers want to understand if the already-approved drug finerenone helps prevent serious heart problems like heart attacks and hospitaliz…

This early-stage study is testing a new oral medication called BAY 2927088 for people with advanced non-small cell lung cancer that has specific genetic changes (EGFR or HER2 mutations). The main goals are to find a safe and tolerable dose, understand how the drug moves through t…

This study is observing adults with hemophilia A who are taking the medication Jivi to see if long-term use improves their joint health. Researchers will use ultrasound scans to check the condition of participants' joints before starting Jivi and again after two years of treatmen…

This study is monitoring the safety of an approved blood thinner called rivaroxaban in Japanese patients with peripheral artery disease (PAD) who have had leg surgery to improve blood flow. Researchers are reviewing existing medical records of 1,500 patients to track serious blee…

This study tested the safety and correct dosing of a drug called riociguat in children aged 6 to 18 with pulmonary arterial hypertension (PAH), a serious condition causing high blood pressure in the lungs. Researchers carefully adjusted the dose for each child based on their age,…

This early-stage study is testing a new radioactive drug called 225Ac-pelgi in men with advanced prostate cancer that has spread and stopped responding to standard treatments. The drug is designed to seek out and deliver radiation directly to cancer cells while sparing healthy ti…

This early-stage study is testing a new immunotherapy drug called BAY 3375968 for people with advanced solid tumors that have not responded to standard treatments. The drug aims to boost the immune system's ability to fight cancer by targeting specific cells that suppress immunit…

This study is monitoring the long-term safety and effectiveness of molidustat, a medication for anemia caused by kidney disease. Researchers are following over 1,000 Japanese patients for up to two years to see how well the drug works in real-world use and to track potential side…

This study is testing whether a new drug called BAY 3283142 can help people with chronic kidney disease by reducing the amount of protein leaking into their urine, which is a sign of kidney damage. About 700 participants will take either the new drug or a placebo pill for 16 week…

This study collects real-world data on how well aflibercept 8 mg eye injections work for people with vision loss from two common eye conditions: neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). Researchers will follow 2500 patients who are alr…

This study is monitoring the safety and long-term effectiveness of the drug sorafenib (NEXAVAR®) in patients with advanced thyroid cancer that cannot be removed by surgery. It will follow 453 patients in Japan for up to two years to track side effects and survival rates. The goal…

This study is testing whether adding the drug darolutamide to standard hormone therapy can better control prostate cancer that has started to return after initial treatment. It involves about 985 men whose blood tests show rising PSA levels but whose scans don't yet show visible …

This study aims to understand how well the medication Jivi works for people with Hemophilia A in their daily lives. It will follow 371 patients who have been treated before to see how many bleeding episodes they have, monitor side effects, and measure their satisfaction with trea…

This study is collecting real-world safety information about rivaroxaban, a blood-thinning medication, in children who have undergone Fontan heart surgery. Researchers are monitoring 61 pediatric patients to better understand the risks of major and minor bleeding events during tr…

This study is testing a new drug called elinzanetant to see if it can reduce the number and severity of hot flashes experienced by women with hormone-positive breast cancer who are taking anti-cancer therapy. About 474 women will take either the study drug or a placebo (a pill wi…

This study looks back at existing health records to understand how doctors in Japan use aflibercept 8 mg, an injection for two common eye conditions that cause blurry vision. Researchers will analyze data from about 3,000 patients who already received this approved treatment as p…

This study aims to understand the relationship between sepsis (a life-threatening infection), dangerous blood clots (VTE), and a serious clotting disorder (DIC). Researchers will analyze the past medical records of 10,000 people who were in intensive care with sepsis and blood cl…

This study is observing 4,500 adults with chronic kidney disease and type 2 diabetes who are starting the medication finerenone as part of their regular doctor's care. Researchers will collect information for one year to learn how the drug is used in real-world settings, includin…

This study aims to learn more about how the drug finerenone works for people in India who have chronic kidney disease and type 2 diabetes. Researchers will look back at the medical records of about 1,200 patients who were already prescribed this approved medication. The goal is t…

This study aims to find out if enough pregnant women with Multiple Sclerosis (MS) in Finland and Sweden used the medication interferon-beta during their second and third trimesters. Researchers are analyzing existing health records to count these cases. The goal is to determine i…

This study looks back at existing medical records to understand how the heart failure drug vericiguat is actually used and how well it works for patients in India. Researchers are analyzing data from about 1,200 Indian adults who were already prescribed this approved medication f…

This study looks back at the medical records of 700 Canadian men with advanced prostate cancer that has spread to other parts of the body. Researchers want to understand what treatment combinations doctors actually use in real-world practice and how long patients stay on these tr…

This study is collecting safety information on an approved prostate cancer drug combination in real-world medical practice. It will follow about 100 Japanese men with advanced prostate cancer that has spread and is still sensitive to hormone therapy. The main goal is to monitor f…