Prostate cancer drug darolutamide under Real-World microscope

NCT ID NCT04122976

Ongoing Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study follows over 800 men with non-metastatic castration-resistant prostate cancer who are already taking darolutamide as part of their normal care. Researchers are tracking side effects and how well the drug controls the cancer in real-world conditions, outside of a strict clinical trial. The goal is to see if the drug's benefits seen in earlier studies hold up in everyday practice.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Darolutamide (Nubeqa)
What this could lead to: If successful, this study could confirm that darolutamide is safe and effective for delaying cancer progression in everyday medical practice.
What could go wrong: This is an observational study, not a controlled trial, so results may be influenced by patient differences. It does not test a new treatment but monitors existing use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Locations

Advanced Urology Institute

Daytona Beach, Florida, 32114, United States
Arizona Institute of Urology

Tucson, Arizona, 85704, United States
Associated Medical Professional Urology

Syracuse, New York, 13210, United States
Associated Urologists of NC

Raleigh, North Carolina, 27612, United States
Baylor Scott & White Medical Center - Temple

Temple, Texas, 76508, United States
Beacon Cancer Care

Beacon, New York, 83814, United States
First Urology, PSC

Jeffersonville, Indiana, 47130, United States
Genesis Comprehensive Prostate Cancer Center

San Diego, California, 92123, United States
Integrated Medical Professionals, PLLC

North New Hyde Park, New York, 11042, United States
Keystone Urology Specialists

Lancaster, Pennsylvania, 17601, United States
Manatee Medical Research Institute

Bradenton, Florida, 34205, United States
Many locations

Multiple Locations, Argentina
Many locations

Multiple Locations, Austria
Many locations

Multiple Locations, Belgium
Many locations

Multiple Locations, Brazil
Many locations

Multiple Locations, Canada
Many locations

Multiple Locations, China
Many locations

Multiple Locations, Colombia
Many locations

Multiple Locations, Denmark
Many locations

Multiple Locations, France
Many locations

Multiple Locations, Germany
Many locations

Multiple Locations, Greece
Many locations

Multiple Locations, Italy
Many locations

Multiple Locations, Japan
Many locations

Multiple Locations, Russia
Many locations

Multiple Locations, Spain
Many locations

Multiple Locations, Taiwan
MultiCare Institute for Research & Innovation

Tacoma, Washington, 98405, United States
New Jersey Urology

Englewood, Colorado, 07631, United States
Oregon Urology Institute

Springfield, Massachusetts, 01106, United States
Premier Medical Group of the Hudson Valley, PC

Poughkeepsie, New York, 12603, United States
Research by Design, LLC

Chicago, Illinois, 60643, United States
Southcoast Centers for Cancer Care

Fairhaven, Massachusetts, 02719, United States
The Urology Center of Colorado

Denver, Colorado, 80211, United States
University of Washington

Seattle, Washington, 98101, United States
Urology Centers of Alabama

Homewood, Alabama, 35209, United States
Urology San Antonio

San Antonio, Texas, 78229, United States
Urology of Virginia

Virginia Beach, Virginia, 23462, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37203, United States
Wichita Urology Group

Wichita, Kansas, 67206, United States

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