Radioactive bullet targets Hard-to-Treat prostate cancer
NCT ID NCT06052306
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study tests a new drug called 225Ac-pelgi for people with advanced prostate cancer that has spread and no longer responds to hormone therapy. The drug delivers a short-range radioactive payload directly to cancer cells, aiming to kill them while sparing healthy tissue. The main goals are to find a safe dose and see if it can shrink tumors or lower PSA levels. About 232 participants will receive up to four treatment cycles and be followed for nearly six years.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Akademiska sjukhuset i Uppsala - Fas 1-enheten
Uppsala, Uppsala County, 751 85, Sweden
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CRST Oy - Clinical Research Services Turku
Turku, Southwest Finland, 20520, Finland
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Cambridge University Hospitals NHS Foundation Trust | Addenbrookes Hospital - Clinical Research Centre
Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
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Centre Hospitalier de l'Universite de Montreal (CHUM) | Oncology
Montreal, Quebec, H2X 0C1, Canada
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Centre hospitalier universitaire de Sherbrooke (CHUS) | Oncology
Sherbrooke, Quebec, J1H 5N4, Canada
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City of Hope - Duarte Cancer Center
Duarte, California, 91010, United States
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Docrates Mehiläinen Syöpäsairaala
Helsinki, Uusimaa, 00180, Finland
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Erasmus Medisch Centrum
Rotterdam, South Holland, 3015 CE, Netherlands
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HUS-Yhtymä, Helsingin yliopistollinen sairaala (HUS) - Syöpäkeskus
Helsinki, Uusimaa, 00029, Finland
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IRCCS Istituto Nazionale Tumori Fondazione Pascale - S. C. Medicina Nucleare e Terapia Metabolica
Naples, 80131, Italy
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Istituto Europeo di Oncologia s.r.l - Medicina Nucleare
Milan, 20141, Italy
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Kantonsspital Baden
Baden, Canton of Aargau, 5404, Switzerland
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Karolinska Universitetssjukhuset - Solna - Fas I-enheten Solna CKC
Stockholm, Stockholm County, 171 76, Sweden
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Kuopio University Hospital, Kuopion yliopistollinen sairaala (KYS) - Syövänhoitokeskus
Kuopio, Northern Savonia, 70210, Finland
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M Health Fairview Masonic Cancer Clinic - Clinics and Surgery Center
Minneapolis, Minnesota, 55455, United States
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Research Institute of the McGill University Health Centre | McConnell Centre for Innovative Medicine
Montreal, Quebec, H4A 3J1, Canada
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Sahlgrenska Universitetssjukhuset - Sahlgrenska Sjukhuset - Klinisk prövningsenhet Fas I/FIH
Gothenburg, Västra Götaland County, 413 46, Sweden
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Skånes Universitetssjukhus - Lund - Onkologens kliniska forskningsenhet
Lund, Skåne County, 221 85, Sweden
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Tampere University Hospital, Tampereen yliopistollinen sairaala (TAYS) - Syöpäkeskus
Tampere, Pirkanmaa, 33520, Finland
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The Newcastle upon Tyne Hospitals NHS Foundation Trust | Freeman Hospital - Cancer Trials Research Centre
Newcastle upon Tyne, Tyne and Wear, NE7 7DN, United Kingdom
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The Royal Marsden NHS Foundation Trust | Sutton - Oak Foundation Drug Development Unit
Sutton, Surrey, SM2 5PT, United Kingdom
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The University of Texas MD Anderson Cancer Center - Texas Medical Center
Houston, Texas, 77030, United States
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Universitair Medisch Centrum Groningen
Groningen, 9713 GZ, Netherlands
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University College London Hospitals NHS Foundation Trust | University College Hospital - NIHR UCLH Clinical Research Facility
London, Greater London, W1T 7HA, United Kingdom
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Universitätsspital Basel
Basel, Canton of Basel-City, 4056, Switzerland
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Univestitätsspital Zürich (USZ)
Zurich, 8091, Switzerland
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Utah Cancer Specialists Cancer Center - Medical Oncology
Salt Lake City, Utah, 84106, United States
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XCancer Omaha
Omaha, Nebraska, 68130, United States