Ain Shams University

This early-stage trial tests whether the drug dexmedetomidine can reduce acute kidney injury in 78 adults undergoing ascending aortic surgery with a heart-lung machine. Half receive the drug, half get a placebo. The goal is to see if the drug's anti-inflammatory effects help prev…

This study looks at whether dulaglutide, a drug used for type 2 diabetes, can help regulate menstrual cycles in adolescent girls with type 1 diabetes who have poor blood sugar control. Researchers will give some participants dulaglutide plus insulin, while others get only insulin…

This study tests whether adding a microfracture procedure to standard meniscus repair improves knee function and healing. Thirty adults with isolated meniscus tears will be randomly assigned to receive either repair alone or repair plus microfracture. Researchers will measure out…

This study tests three different materials used to treat deep cavities in children's permanent molars that are still growing. The goal is to see which material best keeps the tooth alive and allows the root to finish forming normally. Sixty-nine children aged 7 to 10 will receive…

This study tests a modified pinhole surgical technique for treating localized gum recession. It compares using a bi-layer collagen membrane versus a connective tissue graft to cover exposed tooth roots. The trial involves 18 healthy adults with gum recession and will measure chan…

This study compares two ways of making dental onlays (custom tooth restorations) for damaged molars: milling from a solid block versus 3D printing. Thirty adults with cavities, broken teeth, or old fillings will receive either a milled or 3D-printed onlay. Researchers will check …

This study tests whether a daily dose of alpha lipoic acid, an antioxidant supplement, can lower the risk of heart problems in 50 children who are on regular hemodialysis. Participants will either take the supplement or a placebo pill for a period, and researchers will monitor fo…

This study looks at whether giving extra sodium (salt) to premature babies starting at least one week after birth helps them gain weight and grow better. The trial includes 74 preterm infants with low birth weight. Researchers will track their weight for six weeks and check for s…

This study tests two different varnishes for treating white spot lesions, which are early signs of tooth decay common after braces. One varnish uses a self-assembling peptide to help rebuild enamel, while the other delivers calcium and phosphate. Thirty-eight people aged 15-25 wi…

This phase 3 trial tests whether N-acetyl cysteine (NAC) and vitamin D, given alongside standard care, can reduce the risk of esophageal or stomach strictures (scarring that narrows the passage) in children who have swallowed a corrosive substance. Eighty children aged 0–18 with …

This study looks at whether a strong antibiotic called meropenem (a carbapenem) works better than another antibiotic called piperacillin/tazobactam for treating sepsis in burn patients. Sepsis is a life-threatening infection that can happen after severe burns. The study will trac…

This study tests whether a new nano-based paste (chitosan-coated silver nanoparticles) works better than a standard antibiotic paste for treating infected baby molars in children aged 4-8. The goal is to reduce pain, swelling, and infection, and to see which paste kills bacteria …

This study compares two blood tests—mass change in serum albumin and serum lactic acid—to see which better predicts whether non-surgical ICU patients with sepsis will be discharged or die. Researchers will track 40 adults aged 18-70 with sepsis, excluding those with liver disease…

This study tests whether a newer form of iron (liposomal iron) works better than standard iron drops to prevent iron deficiency anemia in premature babies. About 60 preterm infants born at or before 34 weeks will receive either daily standard iron, daily liposomal iron, or liposo…

This study compares two drugs given as a mist before sinus surgery to see if they reduce emergence agitation—confusion, disorientation, or restlessness when waking from anesthesia. Adults aged 21 to 50 having elective functional endoscopic sinus surgery will receive either dexmed…

This study tests whether adding two ultrasound-guided nerve blocks to standard pain relief can lower opioid use and pain after coronary artery bypass grafting. 88 adults having elective bypass surgery will be randomly assigned to receive either the nerve blocks plus standard medi…

This study compares two types of nerve blocks (retrolaminar block vs. serratus anterior plane block) to see which provides better pain relief after radical mastectomy. About 90 women aged 25-65 undergoing breast cancer surgery will receive one of the blocks before general anesthe…

This study tests whether a special oxygen gel applied to stitches after oral surgery can improve wound healing and reduce bacteria. About 44 healthy adults who need dental surgery will receive either the oxygen gel or standard care. Researchers will check healing at 1 and 2 weeks…

This study compares two treatments for severe tooth pain: vital pulp therapy, which tries to save the tooth's nerve, and standard root canal treatment, which removes it. Researchers will measure pain after 24 hours and one week, and check healing at 6 and 12 months using AI to re…

This study compares two types of nerve blocks—erector spinae plane block and quadratus lumborum block—for pain relief after lumbar spine surgery. Forty adults aged 18 to 65 will receive one of the blocks with a numbing medicine (bupivacaine) before surgery. The goal is to see whi…

This study tests whether a combination of two sedatives (ketamine and dexmedetomidine, called Ketodex) works better than dexmedetomidine alone for keeping patients comfortable during awake deep brain stimulation surgery. The surgery is used for movement disorders like Parkinson's…

This study compares total intravenous anesthesia (TIVA) to balanced anesthesia (using inhaled gas) in 60 diabetic patients undergoing video-assisted chest surgery. The goal is to see which method better controls blood sugar and reduces stress during surgery. Researchers will also…

This early-stage trial tests whether adding either dexamethasone or dexmedetomidine to the numbing drug bupivacaine can improve pain control after rhinoplasty (nose job). The study will enroll 90 adults undergoing nose surgery. The main goal is to see how long it takes before pat…

This study looks at whether sugammadex, a drug used to reverse muscle relaxants, can lower the chance of agitation when adults wake up from nasal surgery. About 486 adults aged 18 to 60 having procedures like septoplasty or sinus surgery will be observed. The goal is to see if th…

This study compares two procedures to relieve chronic tailbone pain (coccydynia) that is not related to cancer. About 74 adults aged 20-70 who have not responded to standard medical treatment will be split into two groups. One group will receive conventional radiofrequency ablati…

This study tests whether a nerve block (injecting numbing medicine near the neck) can reduce pain after ear surgery. 46 adults aged 20-40 will receive either the block plus general anesthesia or general anesthesia alone. Researchers will measure pain scores and how much extra pai…

This study tests whether a smartphone-based AI tool can help doctors give a pain-blocking injection to babies having cleft lip repair. The goal is to reduce pain during surgery and the need for extra pain medicine. The study includes 120 infants aged 5-18 months and compares the …

This study tests whether making tiny holes in the jawbone (micro-osteoperforations) can speed up clear aligner treatment for crowded lower front teeth. Twenty adults aged 18 to 35 with mild to moderate crowding will be split into two groups: one gets aligners alone, the other get…

This study compares two types of nerve blocks—RISS block and quadratus lumborum block—for managing pain after open nephrectomy (kidney removal). Fifty adults aged 40-70 will receive one of the two blocks. The main goal is to see which block delays the first request for extra pain…

This study looks at whether an ultrasound measurement of a large vein near the heart (the inferior vena cava) can predict when a patient's blood pressure will drop dangerously during hip replacement surgery. Researchers will measure this vein's flexibility before cement is used t…

This study uses ultrasound imaging to compare the sealing quality of three different supraglottic airway devices (ProSeal LMA, i-gel, and i-gel Plus) in adults undergoing elective surgery. Researchers will measure how well each device blocks the throat and check for signs of stom…

This study looks at how head and neck position (sniffing vs. ramped) and the type of blade used on a video laryngoscope affect how quickly a breathing tube can be placed in 140 severely obese patients (BMI 40 or higher) undergoing elective surgery. The goal is to find the best co…

This study compares total intravenous anesthesia (using propofol and dexmedetomidine) to inhalational anesthesia (using sevoflurane) in 40 adults undergoing inguinal hernia repair. Researchers measure inflammatory markers in the blood before and after surgery, along with hospital…

This study looks at how kangaroo mother care (skin-to-skin contact) affects energy use in preterm babies born at 32-36 weeks. Researchers will measure urine markers of energy and stress, along with heart rate, breathing, and temperature. The goal is to understand if this simple, …

This study looks at how two types of occlusal veneers (thin covers for back teeth) hold up under different biting forces. Researchers will use computer simulations and check the veneers in 8 adults aged 25-35 with certain cavities. The goal is to see which veneer type resists wea…

This study follows 100 head and neck cancer patients receiving standard radiotherapy to see how their teeth, gums, and saliva change over time. Researchers measure gum health, tooth condition, and quality of life before and after treatment. The goal is to better understand these …

This study looks at 37 children with acute respiratory distress syndrome (ARDS) who are on breathing machines. Researchers want to see if measuring certain inflammation markers in saliva works as well as measuring them in fluid from the lungs. If saliva works, it could lead to a …

This study looks at whether using 3 screws instead of 4 to attach a full lower-jaw dental bridge affects bone loss around the implants. Fourteen men with no teeth in their lower jaw and no major health issues are being followed with X-rays over time. The goal is to see if fewer s…

This study looks at whether using sperm from a second ejaculate (collected 1-2 hours after the first) can improve fertilization and embryo quality in ICSI, a type of IVF. Researchers will compare sperm quality and pregnancy outcomes between first and second ejaculates in 108 coup…

This study compares two ways to predict if placing a breathing tube in a child will be difficult: standard physical checks versus ultrasound measurements of the airway. Researchers will study 130 children having planned surgery under general anesthesia. The goal is to see which m…