Can common supplements prevent serious gut damage after poisoning?

NCT ID NCT07229456

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether N-acetyl cysteine (NAC) and vitamin D, given alongside standard care, can reduce the risk of esophageal or stomach strictures (scarring that narrows the passage) in children who have swallowed a corrosive substance. Eighty children aged 0–18 with moderate to severe symptoms are randomly assigned to one of four groups: standard care alone, standard care plus NAC, standard care plus a high-dose vitamin D injection, or standard care plus both NAC and vitamin D. The main goal is to see if these supplements lower the rate of stricture formation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
N-acetyl cysteine and vitamin D
What this could lead to
If it works, this could offer a simple, safe way to prevent serious scarring in the esophagus or stomach after swallowing a corrosive substance.
What could go wrong
This is a small, single-center trial with only 80 children. The results may not apply to everyone, and the supplements might not reduce stricture risk as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Ain Shams University

    Cairo, Egypt