INFLAMMATORY BOWEL DISEASES

This study looked at whether transferring gut bacteria from healthy donors (via fecal microbiota transplantation) can help people with ulcerative colitis, a type of inflammatory bowel disease. 102 participants with mild-to-moderate disease received the treatment. The goal was to …

This study looked at 688 people in South Korea with ulcerative colitis, Crohn's disease, or pouchitis who received Kynteles (Vedolizumab) as part of their normal care. The main goal was to track side effects and see how many patients felt better after treatment. The results help …

This study tested whether adding a drug called bezlotoxumab to a fecal transplant (FMT) could better prevent repeat C. diff infections in adults with inflammatory bowel disease (IBD). About 61 participants received either FMT plus bezlotoxumab or FMT plus a placebo. Researchers t…

This study tested an experimental oral drug called MORF-057 in 39 adults with moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. The goal was to see if the drug could reduce gut inflammation and improve symptoms over 12 weeks. Participants took the drug …

This study looked at 150 adults with Crohn's disease to see if advanced imaging could predict how well the drug Ustekinumab controls inflammation. Researchers measured changes in the gut wall and compared them to standard tests. The goal was to improve treatment monitoring for th…

This study tested whether a blood test measuring proteins can help doctors choose the best treatment for people newly diagnosed with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. 300 patients were split into two groups: one where doctors had …

This study tested whether adding atorvastatin (a cholesterol-lowering drug) to standard mesalamine treatment improves quality of life and reduces inflammation in adults with ulcerative colitis. 54 participants completed the trial. The goal was to see if the drug's anti-inflammato…

This study looked at whether adding the antibiotic minocycline to standard mesalamine therapy can better control ulcerative colitis symptoms. 46 adults with mild to moderate UC took part. The main goal was to measure changes in disease activity using the Partial Mayo Scoring Inde…

This study looked at four new blood markers to help diagnose inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers measured these markers in 70 newly diagnosed patients before and after treatment. The goal is to develop a simple, noninvas…

This study tested whether a special diet called Tasty & Healthy could lower the risk of developing Crohn's disease in 29 healthy people who have a close relative with the disease. Participants followed the diet for 8 weeks, and researchers measured gut inflammation and other risk…

This study looked at whether eating gluten-free can reduce stomach symptoms and tiredness in people with ulcerative colitis. Fifteen adults each spent one week on a gluten-free diet and one week eating high-gluten foods, while tracking their symptoms. The goal was to see if a glu…

This study tested whether ondansetron, a common nausea medicine, helps children aged 2 to 20 better tolerate the bowel preparation needed before a colonoscopy. 41 participants were randomly assigned to receive ondansetron or a placebo. The goal was to see if the drug improved bow…

This study looked at whether fenofibrate, a drug usually used for high cholesterol, can reduce inflammation and improve symptoms in people with mild to moderate ulcerative colitis. Sixty adults took part. The main goal was to see if the drug improved disease activity and quality …

This study looked at whether a short-term, low-calorie plant-based diet (called a fasting mimicking diet) could help reduce depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with mild-to-moderate depression and IBD completed three 5-day diet cycles. R…

This small study tested whether an AI-powered virtual reality app could safely provide mental health support to 22 adults with inflammatory bowel disease (IBD) who also had mild anxiety or depression. The goal was to see if the digital session was practical and acceptable, not to…

This study tested a comprehensive self-management program for people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The program included eight sessions covering topics like symptom tracking, relaxation, diet, and pain management. Research…

This study tested whether nurse coaching could help people with inflammatory bowel disease (IBD) better manage their symptoms, improve self-care, and enhance quality of life. Forty adults with IBD in remission participated. Researchers measured changes in symptom burden, self-car…

This study looked at how being isolated during the 2020 COVID-19 pandemic affected the mental health of 232 people with inflammatory bowel disease (IBD). Researchers used questionnaires to measure feelings like depression, anxiety, and hopelessness. The goal was to understand the…

This study tested whether a transition coach could help 16-17 year olds with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease prepare for adult medical care. 27 teens took part in a coaching program to build self-management skills. The goal was to see if the program wa…

This study took small tissue samples from 16 people with or without inflammatory bowel disease during routine colonoscopies. Researchers grew these samples into mini-organs called organoids in the lab. They then tested how radiation and potential treatments affect these organoids…

This study looked at physical fitness in 100 children and teens (ages 10-17) with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis, or unclassified colitis) and compared them to healthy kids of the same age, weight, and sex. Researchers measured cardiorespi…

This study looked at whether giving nutrition through a small vein in the arm, instead of a large central vein, helps patients recover better after colorectal surgery. 200 adults who had surgery for conditions like cancer or inflammatory bowel disease took part. The goal was to s…

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds precancerous growths better: high-definition white light or dye spraying. Both are standard techniques used during screening. The goal was to learn which appr…

This study looked at how hormonal birth control might help manage inflammatory bowel disease (IBD) symptoms that get worse during a woman's period. Researchers surveyed 50 women with IBD to understand their preferences for birth control and whether they would join a future trial.…

This study analyzed data from over 8,700 pregnant women with inflammatory bowel disease (Crohn's or ulcerative colitis) to see how often doctors follow treatment guidelines and what the risks are for both mother and baby when using antiTNFα drugs. The goal was to better understan…

This study looked at how inflammatory bowel disease (IBD) affects oral health and daily life. Researchers compared 138 adults with IBD to people without IBD, using a questionnaire to measure oral health-related quality of life. The goal was to understand which factors, like medic…

This study aims to create a tool that helps nurses better assess and care for the sexual health needs of men with inflammatory bowel disease (IBD). The research involved 792 participants, including men with IBD and their partners, as well as healthcare professionals. The goal is …

This study looked at whether people with inflammatory bowel disease (IBD) have a higher risk of developing atherosclerosis, a condition where arteries harden and narrow. Researchers measured artery stiffness and thickness in 115 adults with IBD. The goal was to understand the con…

This study looked at colon tissue samples from 40 people to create a detailed map of the cells and genes in the colon. The goal was to better understand how diseases like diabetes, colon cancer, and inflammatory bowel disease develop. No treatments were tested; this was a researc…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This study looked at how well two newer biologic drugs (ustekinumab and vedolizumab) work for Crohn's disease in 50 Chinese patients. Researchers checked for things like healing of the gut lining and symptom improvement, and also looked for side effects. The goal was to find out …

This study looked at whether taking a bowel-cleaning liquid before a capsule endoscopy helps doctors see the small intestine better and find more problems. 230 adults scheduled for the procedure were randomly assigned to get either a split dose, a single morning dose, or no speci…

This study looked at tiny, lab-grown versions of the intestine (called organoids) made from tissue samples of people with inflammatory bowel disease (Crohn's or ulcerative colitis), those with a genetic condition causing colon polyps, and healthy volunteers. The goal was to under…

This study watched 92 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) who were taking vedolizumab as either an IV infusion or a shot under the skin. Researchers did not give any treatment but simply recorded which route patients chose, why they switched or …

This study looked at 40 children aged 6 to 17 with inflammatory bowel disease (Crohn's or ulcerative colitis) to understand how DNA that escapes from cells might make inflammation worse. Researchers analyzed blood, stool, and gut tissue samples to see if a specific pathway (cGAS-…

This study looked at gut bacteria in 15 people with inflammatory bowel disease (IBD) or Parkinson's disease, comparing them to healthy individuals. Researchers analyzed stool and blood samples to see which bacteria were present and whether bacteria were leaking from the gut into …

This early-stage study tested a new oral drug, IPG11406, in 66 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo. This research does not treat any disease but is a necessary first step before testing the drug in …