INFLAMMATORY BOWEL DISEASES

This study tests whether using a computer dashboard to guide infliximab dosing is more effective and safer than standard dosing for people with Crohn's disease or ulcerative colitis. About 124 participants will receive either dashboard-guided or standard dosing. The goal is to se…

This study tests three different doses of an experimental drug called MORF-057 in 280 adults with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The goal is to see if the drug can safely help patients achieve remission, meaning less bleeding, more no…

This study tests whether a plant-based resistant starch, tailored to each child, can help restore a healthier gut microbiome in 80 children with Crohn's disease or ulcerative colitis. Participants will take the starch or a placebo for a period, and researchers will measure change…

This study looks at whether people with inflammatory bowel disease (IBD) have better outcomes and feel more in control of their health when they can text their medical team and regularly report symptoms via text surveys. About 900 participants will be split into two groups: one g…

This study tests whether a plant-based starch, tailored to each child's needs, can help restore a healthier gut microbiome in children with inflammatory bowel disease (Crohn's or colitis). About 100 children with mild disease or in remission will receive the starch for 6 months. …

This study tests a remote monitoring system (smartphone app and medication support) to help people with inflammatory bowel disease (IBD) take their medications as prescribed and track symptoms. About 123 adults starting a new oral or injectable IBD treatment will use the system o…

This study aimed to test whether stem cells from donated bone marrow could safely help people with severe pouchitis, a complication after colon surgery for ulcerative colitis or Crohn's disease. The trial was withdrawn before enrolling any participants, so no results are availabl…

This study is testing whether a personalized diet supplement (a type of starch) can increase helpful gut bacteria in children with Crohn's disease who are already on anti-TNF medication. The goal is to see if this approach can help maintain remission and reduce the need for highe…

This study tests whether adding high-dose vitamin D3 to standard anti-TNF therapy can improve symptoms and reduce inflammation in people with active Crohn's disease or ulcerative colitis. About 100 adults starting anti-TNF treatment will receive either vitamin D3 or a placebo for…

This study looks at whether a virtual reality (VR) program can help people with inflammatory bowel disease (IBD) manage their pain. About 40 adults with IBD and abdominal pain will try the VR program at home for 4 weeks. Researchers want to see if it is easy to use and if it help…

This study aims to better understand what causes inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and other gut problems by analyzing blood and tissue samples from 1,000 patients. Researchers will use advanced lab techniques to track immune system changes over …

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will look at how genes, lifestyle, and other factors affect disease progression and treatment response. The goal is to find be…

This study follows 15,000 adults and children (age 2+) with inflammatory bowel disease (Crohn's, ulcerative colitis, or indeterminate colitis) for up to 5 years. Researchers will collect information on how the disease progresses, how well treatments work, and any side effects tha…

This study tests a thin probe inserted through the nose to measure how leaky the gut is. It involves 15 healthy adults and checks if the device can accurately measure electrical signals in the intestine. The goal is to see if this tool is feasible for future research on gut disea…

This study tests a program to help teens aged 16-17.5 with Crohn's disease or ulcerative colitis transition from pediatric to adult healthcare. The program includes personalized assessments, a navigator, and online skill-building sessions. Researchers will measure how well partic…

This study is a large registry that follows over 2,200 adults with inflammatory bowel disease (IBD) across North America. It does not test new treatments but instead collects real-world data on how approved IBD medications work, their side effects, and how the disease changes ove…

This study is testing a special thermal probe that measures temperature changes in the lining of the colon during a routine colonoscopy. The goal is to see if the probe can detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerati…

This study is collecting blood, stool, and urine samples from 1,000 people with Inflammatory Bowel Disease (IBD) to learn more about the condition. Researchers hope this information will help improve how IBD is managed and treated in the future. Participants must be between 18 an…

This study looks at whether taking extra random biopsies during a colonoscopy helps find precancerous growths in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 1,600 participants will be randomly assigned to one of two biopsy…

This study aims to develop computer-generated metrics from standard tests like endoscopy and scans to better assess inflammatory bowel disease (IBD). Researchers will compare these computer metrics with human evaluations to see if they can improve accuracy. The study involves 200…

This study follows nearly 5,000 children with Crohn's disease, ulcerative colitis, or indeterminate colitis to monitor the long-term safety of their treatments, including the drug infliximab. Researchers collect information on side effects, disease activity, and quality of life o…