INFLAMMATORY BOWEL DISEASES

This study tests a new drug called ATH-063 in people with moderate-to-severe ulcerative colitis who have not responded to biologic treatments. About 120 adults will receive either the drug or a placebo to see if it can reduce symptoms like diarrhea and bleeding. The goal is to fi…

This study tests if xylitol, a common sweetener, can safely clear C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 99 adults with mild or inactive IBD will take either a low or high dose of xylitol or a placebo for four weeks. Researchers …

This study tests a blood-filtering device called Efferon LPS in 40 adults with Crohn's disease or ulcerative colitis during a flare-up. The device is designed to remove harmful substances from the blood to reduce inflammation. Participants will either receive standard care alone …

This study tests whether a brain-training technique called neurofeedback can help reduce muscle and joint pain in people with inflammatory bowel disease (IBD). Researchers will enroll 80 adults with IBD who have persistent pain. Participants will use a special device to learn how…

This study will test a one-day acceptance and commitment therapy (ACT) program designed for veterans who have both inflammatory bowel disease (IBD) and mental health conditions like depression, anxiety, or PTSD. The goal is to help them improve their daily functioning and quality…

This study tests a self-management program designed to help people with inflammatory bowel disease (IBD) improve their health and quality of life. Researchers will enroll 40 adults with active IBD to see if the program is practical and acceptable. The goal is to understand if cha…

This study tests whether duloxetine, a medication that affects brain signals, can reduce disability and psychological distress in adults with inflammatory bowel disease (IBD). About 32 participants will take duloxetine for a period, and researchers will measure changes in anxiety…

This study tests whether a nutraceutical supplement called GenesiDol can reduce musculoskeletal pain in 40 adults with inflammatory bowel disease (IBD) who have persistent joint or muscle pain without active joint inflammation. Participants take the supplement for 8 weeks, and re…

This study will check if low vitamin D levels are linked to more active disease in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will measure vitamin D in 100 adults with IBD and compare it to their current disease act…

This study will check if certain blood cell measurements (platelet count, size, and shape) are linked to how active inflammatory bowel disease (IBD) is. Researchers will compare these blood test results with standard disease activity scores in 84 adults with IBD. The goal is to s…

This study looks at how anxiety, depression, and stress might make advanced treatments for inflammatory bowel disease (IBD) less effective. About 450 people with IBD who are on infusion therapies will fill out questionnaires about their mental health. Researchers will then track …

This study aims to see if anemia (low red blood cells) can help predict how inflammatory bowel disease (IBD) will progress in patients. Researchers will follow 83 adults with IBD at Assiut University Hospitals in Egypt and track their hospitalization rates. The goal is to find a …

This study will use a detailed heart ultrasound technique called speckle tracking to look for early signs of heart trouble in 100 adults with inflammatory bowel disease (IBD). Researchers want to see if this method can catch heart changes before they become serious and how those …

This study follows 75 adults with Crohn's disease or ulcerative colitis who are starting guselkumab, a drug used for inflammatory bowel disease. Researchers want to see if the drug also helps with joint pain and stiffness linked to spondyloarthritis. Participants will report symp…

This study is building a new questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will talk to 275 adults with Crohn's disease or ulcerative colitis to understand their self-care habits, then test the questionnaire to…

This study looks at whether showing patients with inflammatory bowel disease (IBD) a video tailored to their specific disease type helps them prepare better for a colonoscopy. About 300 adults with ulcerative colitis or Crohn's disease will be split into two groups: one gets stan…