INFLAMMATORY BOWEL DISEASES

This study tests if fecal microbiota transplants (FMT) can help people with primary sclerosing cholangitis (PSC), a rare liver disease often linked with inflammatory bowel disease. About 58 adults will receive either FMT or a placebo to see if it lowers liver enzyme levels over 4…

This study tests whether transplanting healthy stool bacteria (fecal microbiota transplantation) can help control ulcerative colitis, a chronic gut disease. About 85 adults with active colitis will receive either the transplant or a placebo. The main goal is to see if a larger tr…

This study tests whether adding fermented foods to the diet can reduce inflammation and improve quality of life in people with mild-to-moderate ulcerative colitis. About 21 adults with confirmed UC and active symptoms will eat fermented foods and be monitored for changes in a sto…

This study tests if pentoxifylline, a drug used for other conditions, can help people with mild to moderate ulcerative colitis (UC). UC causes inflammation in the colon, leading to belly pain, bloody diarrhea, and urgent bowel movements. The trial will enroll 60 adults and measur…

This study tests whether dapagliflozin, a drug already used for diabetes, can help people with mild-to-moderate ulcerative colitis (a type of inflammatory bowel disease). The goal is to see if it reduces inflammation and improves symptoms like diarrhea and abdominal pain. About 5…

This study tests an experimental drug called MORF-057 in adults with moderate to severe Crohn's disease. The goal is to see if it can reduce gut inflammation and improve symptoms. About 385 participants will receive one of three doses or a placebo, and researchers will check resu…

This study is for adults with mild to moderate Crohn's disease who are already on or about to start an IL-23 therapy. Researchers want to see if adding the antifungal drug fluconazole helps patients respond better to their standard treatment. The trial will compare the combinatio…

This study tests whether long-acting antibodies can help people with moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. About 645 adults will receive the antibodies through an IV infusion followed by regular shots under the skin. The goal is to reduce gu…

This study looks at how well newer medications work for children with inflammatory bowel disease (IBD) whose condition did not improve with standard anti-TNF drugs. About 1,100 kids will answer questions about their symptoms and health over time while taking these newer medicines…

This study looks at whether checking and improving nutrition before surgery can help people with inflammatory bowel disease (IBD) recover better. About 150 adults having bowel surgery will be offered nutrition screening and special shakes. The goal is to see if this approach redu…

This study tests whether swallowing frozen capsules containing filtered or whole donor stool can safely bring ulcerative colitis into remission. About 129 adults with mild-to-moderate active disease who have not responded to standard treatments will take the capsules or a placebo…

This study looks at how well and how safely the drug mirikizumab works over a long period (about 3 years) in children and teenagers with moderate-to-severe ulcerative colitis or Crohn's disease. About 150 participants who have already been in earlier studies will continue treatme…

This study tests whether acupuncture can reduce the number of flare-ups in people with Crohn's disease who are currently in remission. About 106 participants will receive either real or sham acupuncture over several months. The goal is to see if this ancient practice can help kee…

This study tests an experimental drug called TQH3906 in adults with moderate-to-severe ulcerative colitis or Crohn's disease. About 135 participants will receive either the drug or a placebo for 12 weeks to see if it safely reduces inflammation and improves symptoms. The goal is …

This study aims to see if robotic surgery is a safe and effective option for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare robotic surgery to the standard laparoscopic approach, looking at things like bloo…

This study tests a new, inexpensive capsule tool that is attached to a string and inserted into the lower gut to take real-time pictures without sedation. It aims to see if the device can capture clear images of the lower gastrointestinal tract in 30 adults, including healthy vol…

This study is testing a new web-based tool that gives people a personalized estimate of their risk for developing Crohn's disease. The tool is for healthy individuals who have a parent, sibling, or child with inflammatory bowel disease. Researchers want to see if learning their p…

This study tests whether virtual reality (VR) therapy can help manage pain for people hospitalized with inflammatory bowel disease (IBD). About 40 participants will try a VR-based brain-gut behavioral program. The goal is to see if the approach is practical and acceptable for pat…

This study tests a virtual group program that teaches teens with inflammatory bowel disease (IBD) coping skills and heart rate biofeedback to reduce stress, anxiety, and depression. About 128 participants aged 13–18 will be randomly assigned to the program or a waitlist. The goal…

This study tests a small device placed under the skin near the tailbone that sends mild signals to a nerve, aiming to reduce sudden bowel urgency in people with ulcerative colitis. About 137 adults with the condition will take part. The device is implanted in a same-day procedure…

This study tests whether adjusting sleep timing and using morning light therapy can improve symptoms and quality of life in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 68 adults with active IBD symptoms and poor quality of…

This study tests whether far-infrared (fIR) therapy is safe and can help ease symptoms in people with Crohn's disease. Forty adults with active Crohn's will receive 10 fIR treatments, give blood and stool samples, and fill out questionnaires. Researchers will compare three differ…

This study is creating a large collection of blood samples and medical information from 3,000 people with autoimmune diseases like lupus and scleroderma. The goal is to help researchers find new markers and develop better treatments. Participants will not receive any experimental…

This study is collecting health information and samples from 100 people with inflammatory bowel disease (IBD) when they change treatments. Researchers will use artificial intelligence to analyze this data and find patterns that could help predict when a treatment change is needed…

This study looks at how the immune system damages the gut in diseases like celiac disease and inflammatory bowel disease. Researchers will analyze immune cells and DNA from 200 adults to understand what goes wrong. The goal is to learn more about these conditions, not to test a n…

This study aims to understand how social factors like insurance and medication adherence affect quality of life in Hispanic and Black patients with inflammatory bowel disease (IBD). Researchers will survey 400 adults with IBD to identify barriers to effective treatment. The goal …

This study looks at whether a toxin called deoxynivalenol (DON), found in grains, might be a risk factor for inflammatory bowel disease (IBD). Researchers will measure DON levels in 100 people—some with Crohn's disease and others without IBD—to see how the body processes it. The …

This study uses health insurance data to find out how many children under 18 in Korea develop Crohn's disease or ulcerative colitis each year, and how many are living with these conditions. It will also look at what treatments they receive, how their treatment changes as they gro…

This study looks at how statins, a common cholesterol medicine, change bile acids and gut bacteria in people with primary sclerosing cholangitis (PSC), a serious liver disease with no cure. Researchers will collect samples from 15 adults with PSC to learn more about what causes t…

This study aims to find out if the unique mix of bacteria and fungi in the gut can predict how well a person with Crohn's disease will respond to treatment. Researchers will collect stool, blood, and tissue samples from 100 adults in British Columbia, Canada, and track their heal…

This study looks at whether a non-invasive intestinal ultrasound can predict when Crohn's disease will come back in patients who are currently in deep remission. Researchers will follow 420 adults for 18 months to see who relapses and compare ultrasound results between those who …

This study aims to find out why some people with inflammatory bowel disease (IBD) continue to have abdominal pain even when their disease is not active. Researchers will follow newly diagnosed patients over time, collecting questionnaires, blood and stool samples, and heart rate …

This study aims to identify markers in blood and tissue samples that can predict how patients with inflammatory bowel disease (IBD) will respond to a type of medication called TNF-alpha inhibitors. Researchers will compare samples from 100 participants, including healthy controls…

This study collects DNA from 1200 patients receiving routine care at the University of Chicago. Researchers look for genetic differences that might affect how well a drug works or how likely it is to cause side effects. The goal is to see if giving this genetic information to doc…

This study aims to collect blood, stool, and tissue samples from 200 children with inflammatory bowel disease (like Crohn's or colitis) and children with other gut issues but no inflammation. Researchers will use advanced technology to study the genes and cells in these samples. …

This study is testing a new medical device that measures nerve responses to assess inflammation in children with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The goal is to develop a more precise way to track disease activity and guide treat…

This study looks at how natural cannabis compounds (phytocannabinoids) affect immune cells from 100 people with chronic inflammatory diseases like rheumatoid arthritis, lupus, and inflammatory bowel disease. Researchers will take a blood sample and expose the cells to different c…

This study is creating a detailed registry of people with rare diseases like amyloidosis, sarcoidosis, and many others. Researchers will collect information from medical records and patient reports to learn how these diseases progress, how they are treated, and what outcomes pati…

This study is testing a new device called a wireless thermal capsule—a pill you swallow that measures temperature inside your digestive tract. The goal is to see if it can help detect diseases like Crohn's disease by spotting unusual heat patterns. Ten healthy adults will take pa…

This study looks at how nutrition and body composition (like muscle and fat) impact the health of people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical treatments or having sur…