Vaginal disorder

This study tests a new vaccine called Candi5V in 251 women who get frequent yeast infections (at least 3 per year). The vaccine is designed to train the body's immune system to fight Candida fungus. Researchers will check if it's safe and if it reduces future infections.

This phase 3 trial tests whether adding the drug triapine to standard radiation and cisplatin improves survival in women with advanced cervical or vaginal cancer. About 450 participants receive either standard treatment or standard treatment plus triapine. The study aims to see i…

This phase II trial tests whether adding cabozantinib to the immunotherapy drug nivolumab can prevent mucosal melanoma from returning after surgery. About 101 patients with resected mucosal melanoma will receive either nivolumab alone or nivolumab plus cabozantinib. The study aim…

This phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…

This study tests a combination of three drugs—bintrafusp alfa, PDS01ADC, and entinostat—in adults with advanced HPV-related cancers (like cervical, anal, or throat cancer) or certain colon cancers that haven't responded to standard treatment. The goal is to find a safe dose and s…

This early-phase study tested an oral drug called triapine added to standard chemotherapy (cisplatin) and radiation for people with advanced cervical or vaginal cancer. The main goals were to find the safest dose and check how well the body absorbs the drug. Twenty-one participan…

This study tests an HPV vaccine (PRGN-2009) alone or with a drug called M7824 in people with HPV-positive cancers like cervical, anal, and throat cancers. The goal is to find a safe dose and see if the combination boosts the immune system's attack on tumors. The trial includes 39…

This study is for women who previously received a vaginal probiotic (LC106) for bacterial vaginosis in an earlier trial. Researchers want to see if the good bacteria from the probiotic can stay in the vagina over time. About 71 women will be followed, and the main goal is to chec…

This early-phase trial tests whether using MRI scans to guide the placement of internal radiation (brachytherapy) can improve treatment for women with advanced cervical or vaginal cancers linked to HPV. The study involves 26 participants and compares MRI-guided placement to stand…

This phase II trial tests whether combining two drugs, atezolizumab and bevacizumab, can shrink rare solid tumors like appendix cancer, anal cancer, and mesothelioma. About 133 participants with various rare cancers will receive the drugs intravenously. The goal is to see if the …

This study tests a combination of two drugs—TG4001 (a biologic that targets HPV) and avelumab (an immunotherapy)—in people with advanced HPV-16 cancers that cannot be removed by surgery or cured by radiation. The trial has two phases: first, to find a safe dose, and second, to se…

This study tests whether giving menstrual cups to economically vulnerable women in Kenya can lower rates of bacterial vaginosis (BV) and sexually transmitted infections (STIs). The cup is a reusable silicone device that collects menstrual blood and can be worn during sex. Researc…

This early-stage study tests a new treatment called T-Plex for people with advanced solid tumors (like head and neck, cervical, or melanoma) that haven't responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to recognize and…

This study tests whether transferring healthy vaginal bacteria from donors can cure recurrent bacterial vaginosis (BV). Ten women with frequent BV will receive the transplant. The goal is to restore natural balance and prevent repeat infections without antibiotics.

This phase 1 trial is testing a new imaging tracer called 68Ga-FAPI-46 to see where it collects in normal and cancerous tissues. About 30 people with various solid tumors or blood cancers will receive the tracer and then undergo a PET/CT scan. The goal is to understand how the tr…

This study looks at whether a blood test that detects tumor DNA can find early signs of cancer returning in people treated for HPV-positive pelvic cancers (like cervical or anal cancer). Researchers will take blood samples from 172 patients during regular follow-up visits. The go…

This study tests whether a short, modified exposure therapy given soon after rape can prevent post-traumatic stress disorder (PTSD) in women. About 166 women who have experienced sexual assault will be randomly assigned to either the brief therapy or standard care. The goal is to…

This study aimed to find out if checking pregnant women for bacterial vaginosis every two weeks could reduce the chance of early delivery. It planned to include women with a history of preterm birth. However, the trial was withdrawn before any participants were enrolled, so no re…

This study is testing whether virtual reality exposure therapy can help people with vaginismus, a condition where the pelvic floor muscles tighten involuntarily, making vaginal penetration painful or impossible. The idea is that gradually facing feared situations in a safe virtua…

This phase 2 trial tests whether injecting platelet-rich plasma (PRP) into the vulva and vagina can improve symptoms of genitourinary syndrome of menopause (GSM) in breast cancer survivors. GSM causes dryness, burning, and pain, often worsened by cancer treatments. The study enro…

This study tests a product called pHyph for treating thrush (a vaginal yeast infection) in adult women. The goal is to see if pHyph reduces symptoms like itching, burning, and irritation. 48 women will either use pHyph daily for 6 days or receive no treatment, and researchers wil…

This study aimed to see if adding a hyaluronic acid-based vaginal moisturizer to standard vaginal estrogen therapy provides extra relief for menopause-related vaginal symptoms. It planned to enroll postmenopausal women aged 45 and older who had not used these treatments recently.…

This study tests four different vaginal treatments (estrogen, DHEA, estrogen with probiotics, and a moisturizer) in 160 breast cancer patients who have vaginal atrophy due to hormone therapy. The goal is to see which treatment best relieves symptoms like dryness and pain, and imp…

This study tests a non-hormonal laser treatment for genitourinary syndrome of menopause (GSM) in women who have completed cancer treatment. GSM causes symptoms like vaginal dryness and pain, which can affect quality of life. The study will compare the laser therapy to a control g…

This study tests a gel called Hyalo Gyn® to see if it helps with vaginal dryness in women who have had breast cancer and are past menopause. About 156 women will use the gel or a placebo every three days for 12 weeks. The goal is to see if the gel reduces dryness and other sympto…

This study tests a device called INNEA AQUA, used in the vagina, to see if it safely reduces symptoms of vulvo-vaginal atrophy (VVA) in adult women. VVA can cause itching, soreness, and pain during sex. The trial compares the device to standard care in 62 women aged 18-75. Resear…

This study looks at two treatments for vaginal dryness in women with estrogen receptor-positive breast cancer who are taking aromatase inhibitors. One group uses a vaginal estrogen ring that releases a low dose of estrogen over 90 days, while the other uses a non-hormonal vaginal…

This study tests an online program called Day by Day for women with stage III or IV gynecologic cancer who have high fear of their cancer getting worse or coming back. The program teaches skills to manage anxiety and reframe worries. About 23 women will try the program for 12 wee…

This study tests whether injecting platelet-rich plasma (PRP) — made from a woman's own blood — into the vaginal wall can improve sexual function and reduce dryness caused by menopause. Thirty postmenopausal women with genitourinary syndrome of menopause will receive either PRP o…

This study follows 21 patients who had a very extensive surgery called pelvic exenteration for recurrent gynecologic cancer. The goal is to understand how the surgery affects their quality of life and sexuality using standard questionnaires. The results will help doctors better p…

This study follows 72 women with pelvic cancers (anal, cervical, endometrial, rectal, vaginal, or vulvar) who are receiving radiation therapy. Researchers will use pelvic exams and surveys to measure changes in vaginal health, sexual function, and quality of life over two years. …

This study looks at 120 Canadian women to understand why some get repeated yeast infections while others don't. Researchers will compare the vaginal yeast and bacteria of women with their first infection, those with recurrent infections, and those with yeast but no symptoms. Part…

This study watches a single gynecology resident as they learn to perform a hysterectomy through the vagina using a special camera, leaving no belly scars. The goal is to see how quickly the resident improves, measuring surgery time and any complications. Nineteen women with benig…

This study follows women who have had pelvic exenteration—a surgery removing the lower colon, rectum, and bladder—for gynecologic cancers like cervical or endometrial cancer. Researchers want to see if factors like tumor size or surgery type affect complications, quality of life,…

This trial was designed to test whether an online mental health program could help women with advanced gynecologic or breast cancer manage their fear of the cancer returning or getting worse. The study planned to compare the online program to standard educational materials. Howev…

This study in Nepal tests whether using rapid point-of-care tests for sexually transmitted infections can reduce the overuse of antibiotics for vaginal discharge. About 1,500 women will be split into three groups: standard care, test-guided treatment, or test-guided treatment plu…

This study is creating a biobank—a collection of blood samples and health data—to help researchers better understand gynecological disorders, infertility in men and women, and pregnancy-related conditions. Up to 3,000 participants will provide samples at San Raffaele Hospital in …