Synovium disorder

This study tested a drug called pexidartinib (TURALIO) in 9 Japanese adults with tenosynovial giant cell tumor (TGCT), a rare, non-cancerous growth in the joints that causes pain and limits movement. The goal was to see if the drug is safe and can shrink tumors in people whose tu…

This study tested whether injecting bevacizumab (a drug that blocks blood vessel growth) into the joints of people with hemophilia can prevent repeated bleeding episodes. Eighteen participants with chronic synovitis (joint inflammation) received the injection. Researchers measure…

This study tested nilotinib, a drug originally used for leukemia, in 17 patients with relapsed or metastatic pigmented villonodular synovitis (PVNS) or related giant cell tumors. The goal was to see if the drug could stop tumor growth or improve symptoms. Results focused on how l…

This trial tests whether using an iPhone with interactive rehabilitation software (HappyGoGo) for daily home exercise can improve pain, range of motion, and quality of life in people with frozen shoulder. Thirty participants are randomly assigned to either standard rehab plus the…

This trial tests whether virtual reality exercise games or electrical muscle stimulation can reduce shoulder pain and improve movement in people with chronic kidney disease who are on dialysis. Participants will receive one of the two therapies several times a week for eight week…

This trial tests whether a wide-awake local anesthesia technique called WALANT can match the results of general anesthesia for shoulder manipulation in people with frozen shoulder. Adults who have had symptoms for at least six months without improvement are randomly assigned to o…

This trial tests two ways to deliver a steroid injection for adhesive capsulitis, or frozen shoulder — a condition that causes pain and stiffness. One method injects into the shoulder joint, the other into the tissue around it, both guided by ultrasound. Researchers want to see w…

This study investigates whether adding osteopathic visceral manipulation (OVM) — gentle mobilization of the liver and diaphragm — to a standard physical therapy program can reduce pain, improve range of motion, and lessen disability in people with right shoulder adhesive capsulit…

This study compares two injection treatments for frozen shoulder (adhesive capsulitis). One group receives a standard steroid injection, while the other gets the same steroid plus extra saline to gently stretch the shoulder capsule. Researchers will measure pain, range of motion,…

This study compares two treatments for frozen shoulder (adhesive capsulitis): applying an anti-inflammatory gel through ultrasound (phonophoresis) versus a muscle relaxation exercise technique (post-isometric facilitation). About 45 adults aged 30–40 with the second stage of froz…

This study tested whether steroid injections given every two weeks can improve shoulder function and reduce pain in people with frozen shoulder. Forty adults received either an ultrasound-guided injection into the shoulder or a shot in the buttock, plus a placebo. The goal was to…

This study compares two ultrasound-guided injection treatments for adhesive capsulitis, also known as frozen shoulder. One group receives a steroid and numbing medicine injected directly into the shoulder joint, while the other group gets the same medicine injected near the supra…

This study compared two physical therapy techniques—Cyriax capsular stretching and Mulligan mobilization—for people with frozen shoulder (adhesive capsulitis). Thirty adults aged 30–65 with symptoms lasting over three months took part. Researchers measured pain, shoulder movement…

This study tested two hands-on treatments for frozen shoulder (adhesive capsulitis) in 66 adults aged 40-65. One group received quick thrusts (HVLA), the other a gentler muscle energy technique (MET), both alongside standard physical therapy for four weeks. Both approaches reduce…

This study looked at whether adding ultrasound-guided hyaluronic acid injections to a standard rehab program helps people with frozen shoulder. Sixty adults aged 40 to 70 with frozen-phase adhesive capsulitis took part. One group got three weekly injections plus six weeks of reha…

This study tested whether virtual reality-based exercises are more effective than standard physical therapy for people with frozen shoulder (adhesive capsulitis). 90 adults aged 18-65 with limited shoulder motion took part. Researchers measured pain, range of motion, and daily fu…

This study tested a new injection treatment called PIT (using a sugar-water solution) against TENS (a mild electrical stimulation device) for people with shoulder pain. Thirty-two adults with ongoing shoulder pain received either PIT or TENS, plus exercises, over two weeks. The g…

This study compared two injections for sacroiliac joint pain: platelet-rich plasma (PRP) made from the patient's own blood, and a standard steroid/anesthetic mix. Fifty adults with confirmed sacroiliac joint pain received one of the two injections. Researchers measured pain level…

This study looked at whether adding a technique called tissue flossing (wrapping an elastic band around the lower leg and doing exercises) to standard heel-drop exercises can reduce pain and improve movement in people with Achilles tendinopathy. Thirty adults aged 20-45 with long…

This study tested two different physical therapy programs for people with chronic shoulder pain caused by subacromial bursitis. All 60 participants received three ultrasound-guided steroid injections, then were randomly assigned to either a special movement therapy (PNF) or stand…

This study tested whether adding Niel Asher Technique (a type of massage) and scapular clock exercises to standard physical therapy helps people with frozen shoulder (adhesive capsulitis). 34 adults aged 40-55 took part. The goal was to see if the combo reduced pain, improved mov…

This study compared digital physical therapy (using an app or online guidance) with standard in-person therapy for people with frozen shoulder (adhesive capsulitis). 40 adults aged 35-55 took part. The goal was to see which approach better reduces pain and disability, and which i…

This study tested whether injecting hyaluronic acid into the shoulder joint could help people with frozen shoulder. 46 participants received either the injections plus physical therapy or physical therapy alone. Researchers measured shoulder movement and disability over 26 weeks …

This study tested whether an injection made from human placental connective tissue (ActiveMatrix) works better than the usual steroid shot for frozen shoulder. 56 adults with frozen shoulder received either ActiveMatrix or a corticosteroid injection. Researchers measured pain and…

This study looked at two different physical therapy techniques—Gong mobilization and Spencer technique—to see which works better for diabetic patients with frozen shoulder. 36 adults with diabetes and stage II frozen shoulder took part. Researchers measured pain, range of motion,…

This study looked at whether a technique called gong mobilization, with or without a quick spinal adjustment, can reduce pain and improve movement in people with frozen shoulder (adhesive capsulitis). Thirty-six adults aged 40 to 60 with stage 2 frozen shoulder took part. They re…

This study compared two common physiotherapy techniques—Mulligan and Maitland mobilizations—in 42 adults aged 35-50 with frozen shoulder (adhesive capsulitis). The goal was to see which method better reduces pain, improves shoulder movement, and enhances daily function and qualit…

This study tested two physical therapy techniques—repeated contractions and hold-relax—on 66 people with frozen shoulder (stage 2). The goal was to see which method better reduces pain, improves range of motion, and eases disability. Participants did scapular exercises in diagona…

This study tested whether a shorter, 6-session exercise and education program could help people with gluteal tendinopathy, a common cause of hip pain in women over 40. 65 adults aged 35-70 with chronic hip pain took part. The goal was to see if a larger trial is possible, not to …

This study tested two common treatments for Achilles tendinopathy in 24 male football players aged 18-30: eccentric calf exercises (lowering the heel off a step) and wearing heel insoles. Over 12 weeks, researchers measured pain, ankle movement, and function. The goal is to find …

This study tested whether a combination of two medicines (etoricoxib and betamethasone) works better than just one (etoricoxib) for reducing pain from sudden joint swelling conditions like bursitis, tendinitis, or synovitis. About 89 adults with pain in their shoulder, elbow, kne…

This study tested different doses of shockwave therapy in 48 adults with frozen shoulder (adhesive capsulitis). Participants received focused shockwaves to the shoulder, and researchers measured changes in range of motion and shoulder function. The goal was to find the most effec…

This study looked at whether Pilates exercises can reduce shoulder pain and improve function in people with subacromial impingement syndrome, a common cause of shoulder pain. 34 adults with shoulder pain for at least three months took part. They were split into two groups: one di…

This study tested whether adding brain-based treatments—like pain education and sensory training—to standard physical therapy helps people with frozen shoulder more than therapy alone. 21 adults with chronic frozen shoulder were split into two groups: one received only convention…

This study looked at whether inhaling a mixture of oxygen and nitrous oxide (sometimes called laughing gas) during physical therapy helps people with frozen shoulder. 75 adults with frozen shoulder took part. Some received the gas mix during therapy, while others inhaled a placeb…

This pilot study tested an ultrasound-guided injection of triamcinolone (a steroid) mixed with lidocaine (a numbing agent) directly into the knee's medial plica fold. The goal was to see if this targeted approach could reduce pain and improve function in 30 people with medial pli…

This study tested whether adding hyaluronic acid to a ketorolac injection helps frozen shoulder more than ketorolac alone. Fifty-six adults with frozen shoulder received one shot of either the combination or just ketorolac, then followed a rehab program. After 24 weeks, both grou…

This study tested a treatment called pulsed radiofrequency, which uses gentle electrical pulses to calm the nerve that supplies most of the shoulder's feeling. It was given to 32 patients over 65 with frozen shoulder (adhesive capsulitis), a condition that causes pain and stiffne…

This study looked at 55 adults with severe frozen shoulder (pain and stiffness for at least 3 months) who had not improved with standard treatments. They received one to three injections of steroid and numbing medicine into the shoulder joint, followed by intensive physiotherapy.…

This study tested whether giving general practitioners a simple, evidence-based guideline improves care for people with shoulder pain. 160 adults with shoulder pain took part in Norwegian GP clinics. Researchers measured pain, disability, and quality of life to see if the guideli…

This study looked at 60 people with frozen shoulder to understand how fear of movement (kinesiophobia) relates to pain, stiffness, and daily life. Participants had their shoulder motion measured and filled out questionnaires. The goal was to see if this fear makes symptoms worse,…

This study compared shoulder muscle strength and fatigue between 60 people with frozen shoulder (adhesive capsulitis) in the recovery phase and healthy individuals. Researchers used a special machine to measure peak torque and fatigue index of shoulder muscles. The goal was to un…

This study looked at 87 people with frozen shoulder to see if their level of central sensitization—a condition where the nervous system is extra sensitive to pain—affected how well they responded to a shoulder injection. Researchers measured central sensitization using a question…