Frozen shoulder combo shot shows small extra benefit in motion

NCT ID NCT07183436

Completed Symptom relief Sponsor: Mahidol University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding hyaluronic acid to a ketorolac injection helps frozen shoulder more than ketorolac alone. Fifty-six adults with frozen shoulder received one shot of either the combination or just ketorolac, then followed a rehab program. After 24 weeks, both groups had similar pain and function improvements, but the combination group gained a little more shoulder rotation and adduction. Both treatments were safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hyaluronic acid and ketorolac injection
What this could lead to: If the combination proves superior in larger studies, it could offer a slightly better option for improving shoulder rotation in frozen shoulder patients.
What could go wrong: This was a small, single-center trial with only 56 participants. The added benefit was modest and limited to certain movements, so the combination may not be meaningfully better than ketorolac alone.

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Conditions

The condition(s) this trial relates to.

bursitis frozen shoulder Shoulder Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADHESIVE CAPSULITIS OF THE SHOULDER

Contacts and locations

Locations

Faculty of Medicine Ramathibodi Hospital, Mahidol University

Bangkok, 10400, Thailand

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