New allograft injection could thaw frozen shoulders better than steroids
NCT ID NCT05844930
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether an injection made from human placental connective tissue (ActiveMatrix) works better than the usual steroid shot for frozen shoulder. 56 adults with frozen shoulder received either ActiveMatrix or a corticosteroid injection. Researchers measured pain and disability using a standard questionnaire over 6 months. The goal was to see if the new treatment is safe and more effective at easing pain and restoring movement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Human placental connective tissue-derived allograft (ActiveMatrix) and corticosteroid (triamcinolone) injection
- What this could lead to
- If it works, this could offer a new treatment option for frozen shoulder that may reduce pain and improve movement better than standard steroid injections.
- What could go wrong
- This is a small pilot study with only 56 participants, so results may not apply to everyone. The allograft is new for this condition, and its safety and effectiveness are still being tested.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ADHESIVE CAPSULITIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Hormone therapy may thaw frozen shoulders faster — a trial puts it to the test
- Can a neck glide unlock a frozen shoulder?
- Can a specific mobilization technique unfreeze a frozen shoulder faster?
- Can a smartphone game help heal a frozen shoulder?
- Precision injection showdown: which spot stops frozen shoulder pain best?
- Microembolization may outlast steroid shots for frozen shoulder