New allograft injection could thaw frozen shoulders better than steroids
NCT ID NCT05844930
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether an injection made from human placental connective tissue (ActiveMatrix) works better than the usual steroid shot for frozen shoulder. 56 adults with frozen shoulder received either ActiveMatrix or a corticosteroid injection. Researchers measured pain and disability using a standard questionnaire over 6 months. The goal was to see if the new treatment is safe and more effective at easing pain and restoring movement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Human placental connective tissue-derived allograft (ActiveMatrix) and corticosteroid (triamcinolone) injection
What this could lead to
If it works, this could offer a new treatment option for frozen shoulder that may reduce pain and improve movement better than standard steroid injections.
What could go wrong
This is a small pilot study with only 56 participants, so results may not apply to everyone. The allograft is new for this condition, and its safety and effectiveness are still being tested.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States