Frozen shoulder breakthrough? injection combo shows promise in small study

NCT ID NCT04653636

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looked at 55 adults with severe frozen shoulder (pain and stiffness for at least 3 months) who had not improved with standard treatments. They received one to three injections of steroid and numbing medicine into the shoulder joint, followed by intensive physiotherapy. The goal was to find out which patients respond best, based on MRI and clinical factors, with pain and function measured after one month.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
corticosteroid injection (betamethasone or triamcinolone hexacetonide) with lidocaine and saline
What this could lead to
If successful, this could help identify which patients with severe frozen shoulder benefit most from this injection-plus-physiotherapy approach, leading to more personalized treatment.
What could go wrong
This is a small, completed study (55 people) looking for predictive factors, not a large trial testing effectiveness. Results may not apply to all patients, and the procedure carries risks like infection or temporary pain increase.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis

    Paris, IDF, 75014, France

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