Spastic cerebral palsy

This trial tests whether a virtual reality (VR) gamified rehabilitation program, using Xbox Kinect, can improve functional mobility, balance, and trunk control in children with spastic diplegic cerebral palsy. Forty-two children aged 7-15 years with GMFCS levels II and III will b…

This trial compares two rehabilitation approaches—Modified Constraint-Induced Movement Therapy and Mirror Therapy—to see which better improves grip strength, manual dexterity, and spasticity in children with spastic hemiplegic cerebral palsy. The study involves 42 children aged 5…

This trial investigates whether playing virtual reality-based balance games can improve mobility and brain function in adults with cerebral palsy. Participants will receive standard physical therapy plus either VR games or traditional balance exercises over 8 weeks. Researchers w…

This study tests two rehabilitation methods—proprioceptive neuromuscular facilitation (PNF) and task-oriented training (TOT)—alone or combined, to improve arm and hand function in children aged 6–12 with spastic diplegic cerebral palsy. Sixty-three participants will receive 45-mi…

This trial tests a modified leg therapy for children ages 6 to 8 with hemiplegic cerebral palsy, a condition that affects one side of the body. The therapy uses a knee scooter to encourage use of the weaker leg during walking tasks. Researchers will measure changes in walking pat…

This study tests whether adding immersive virtual reality (VR) games to standard physical therapy helps teenagers with spastic diplegic cerebral palsy improve their balance and coordination more than therapy alone. Forty adolescents aged 10 to 19 will be randomly assigned to rece…

This study tests whether combining task-oriented training with functional electrical stimulation (FES) can improve balance and ankle strength in children aged 6-9 with hemiparesis (weakness on one side). Thirty-six children will participate in a structured exercise program three …

This study tests whether freezing specific nerves (cryoneurolysis) can reduce shoulder pain and improve movement in people with spasticity from conditions like stroke or brain injury. Fifty adults will either receive one session of nerve freezing or one session of Botox injection…

This study tests a surgery that moves a nerve from the neck to help people with arm weakness after a stroke. It is for those whose arm has not improved with rehab. The goal is to see if the surgery can improve arm movement and control.

This study tests whether a child's own bone marrow stem cells can safely improve movement and muscle control in cerebral palsy caused by lack of oxygen at birth. Fifty-eight children aged 1 to 10 will be split into two groups: one gets stem cell infusions right away, the other wa…

This study tests whether dynamic surface exercise training (exercises on unstable surfaces like physio balls) can improve mobility, balance, and coordination in children aged 5-8 with diplegic cerebral palsy. 14 children will be randomly assigned to either the dynamic surface exe…

This study tests whether a child-friendly core exercise program, delivered via video, can improve balance and mobility in children aged 6-12 with spastic cerebral palsy. Half of the 54 participants will do the Fun-Core exercises at home 3 times a week for 8 weeks, while the other…

This study tests a program called Therapy Together, where caregivers lead hand therapy exercises for young children with cerebral palsy who have limited use of one hand. The program lasts 8 weeks and aims to improve hand function and daily skills. Researchers will compare these c…

This study tests whether a smartphone's built-in accelerometer can reliably measure walking patterns in children aged 6 to 12 with unilateral spastic cerebral palsy. Thirty-five children will walk 10 meters at a comfortable speed while a smartphone secured at their lower back rec…

This study tests whether extracorporeal shock wave therapy (ESWT) can reduce spasticity—stiff, tight muscles—in the wrists of people who had a stroke at least six months ago. Researchers will give 32 participants either ESWT plus standard rehab or just standard rehab. They will u…

This trial tests whether a home-based system combining a humanoid robot with virtual reality games can improve arm function in children with cerebral palsy. About 60% of these children have impaired arm use, and doing enough daily exercises is often boring and hard to stick with.…

This trial tests whether delivering electrical pulses to spinal nerves can temporarily calm spastic muscles in children with cerebral palsy. Researchers will stimulate the dorsal root nerves during a planned surgery and measure muscle responses. The goal is to see if this stimula…

This study tests a therapy called HABIT-ILE, which uses structured hand and leg exercises, to see if it can improve both motor skills and cognitive functions like memory and attention in children with spastic cerebral palsy. 42 children will receive 90 hours of therapy and be com…

This pilot study tests whether a 10-week treadmill training program combined with blood flow restriction (using cuffs on the legs) can safely improve walking speed in 13 children aged 8 to 18 with cerebral palsy. The children will walk on a treadmill three times a week, gradually…

This study is testing whether a non-invasive brain stimulation technique called rTMS, when combined with standard rehabilitation, can improve leg movement and reduce muscle stiffness in children with spastic diplegic cerebral palsy. The study will include 20 children aged 5 to 18…

This study tests whether pairing electrical stimulation of the brain's hand area with stimulation of a wrist nerve can improve hand and arm function in adults with hemiplegic cerebral palsy (hCP). Researchers will measure changes in muscle responses and dexterity tasks like movin…

This study tests whether adding motor imagery (mentally practicing movements) and action observation (watching movements) to standard physical therapy can improve gross motor function, upper limb skills, and quality of life in children with unilateral cerebral palsy. Forty-eight …

This study tests whether adding a sensory walkway to standard physical therapy can improve walking in children aged 5-7 with spastic diplegic cerebral palsy. 44 participants will either receive conventional therapy alone or conventional therapy plus sensory walkway training for t…

This study tests whether a non-invasive technique called transcutaneous spinal cord stimulation (tSCS), combined with specific arm and hand exercises, can improve upper limb function in children and young people (ages 12-21) with hemiplegic cerebral palsy. The treatment involves …

This study looks at whether a 10-week plan with a leucine supplement is practical for children with spastic cerebral palsy. It also checks for early signs of muscle growth using ultrasound. Only 5 children will take part to see if they can stick with the supplement and if it affe…

This study tests a new therapy called MOBILE to help children with cerebral palsy walk better. Fourteen children will try the therapy for 30 hours over 6 weeks. The goal is to see if the therapy is acceptable and helpful for children and families in a community setting.

This study tests whether a non-invasive brain stimulation technique called rTMS, followed by intensive arm training, can reduce muscle stiffness (spasticity) in children aged 7–18 with hemiplegic cerebral palsy. Twenty participants will receive either real or sham rTMS over 10 da…

This study tests whether adding task-specific electrical stimulation to standard physical therapy can improve upper limb gross motor skills in children aged 2 to 6 with spastic quadriplegia cerebral palsy. Thirty children will be split into two groups: one gets standard therapy, …

This study looks at whether adding a single session of whole-body vibration to treadmill training can improve walking and reduce muscle stiffness in children with cerebral palsy. About 20 kids aged 6-17 who can walk will participate. The goal is to see if combining these therapie…

This small safety trial tests whether a non-invasive device that stimulates the vagus nerve through the ear can safely improve hand and arm function in 10 adolescents with spastic cerebral palsy. Participants will use the device during upper limb rehabilitation sessions. The main…

This study tests two new methods to improve hand function in children with cerebral palsy: a virtual reality system called Leap Motion that uses hand-tracking games, and neuromuscular electrical stimulation (NMES) that uses mild electrical pulses to activate muscles. Thirty child…

This study tests whether simple brain gym exercises—like drinking water, cross crawls, and deep breathing—can improve balance and quality of life in children aged 6 to 8 with spastic diplegia, a type of cerebral palsy. Forty-four children will be split into two groups: one doing …

This study tests whether adding playful nerve-gliding activities to standard physical therapy can improve hand grip strength and dexterity in children with cerebral palsy. About 34 children aged 6-12 will be split into two groups: one gets routine therapy plus play-based hand exe…

This study tests a new therapy that combines a brain-computer interface (BCI) with electrical stimulation to help children with cerebral palsy move their arms and hands. Eight children aged 12 to 17 will wear a cap that reads their brain signals, and when they imagine moving thei…

This study tests whether using a ride-on toy for 6 weeks can help children with cerebral palsy use their weaker arm and hand more. Ten children will wear a mitten on their stronger hand to encourage using the other hand while driving and playing. Researchers will measure changes …

This study tests whether a mixed-reality video game called Bootle Blast can help children aged 6–17 with hemiplegic cerebral palsy improve their arm and hand skills through home-based play. About 46 participants will either start the game right away or wait 12 weeks while continu…

This study tests whether a 12-week functional power training program (MegaPower) helps children with cerebral palsy achieve their personal participation and activity goals better than usual care. The trial will include 66 children aged 4-12 who can walk with or without help. Rese…

This study tests a treatment that uses precise radiation beams to target nerves in the back, aiming to reduce muscle tightness (spasticity) caused by stroke, spinal cord injury, or cerebral palsy. About 22 people will be randomly assigned to receive either the real treatment or a…

This study looks at whether botulinum toxin type A injections can improve hand and leg function and quality of life in 30 children aged 8 to 17 with spastic hemiparetic cerebral palsy. Participants receive one injection and are followed for 12 weeks. The goal is to see if this tr…

This study tests a structured exercise program called task-oriented circuit training in 34 children aged 5-12 with hemiplegic cerebral palsy. The program includes 14 stations targeting walking, balance, and strength. Researchers will measure improvements in walking distance and d…

This study tests whether adding a robotic glove to standard hand therapy (CIMT) can improve hand dexterity and grip strength in children aged 6-12 with hemiplegic cerebral palsy. Half of the 34 participants will receive CIMT alone, while the other half will also use a robotic glo…

This study tests a 10-week hand strength training program for 14 children aged 6-12 with spastic cerebral palsy. The goal is to see if it improves their grip strength and ability to manipulate objects in their hand. Researchers will measure changes using a dynamometer and the Mel…

This study tests whether adding a special exercise program (kinesiotherapy) to standard physical therapy can improve arm movement and daily living skills in children aged 8-13 with hemiplegic cerebral palsy. 28 children will be split into two groups: one gets kinesiotherapy plus …

This study tests whether adding a mild electrical stimulation to the skin of the affected hand (called SAES) can improve hand function in children aged 6-18 with hemiparesis (one-sided weakness) due to cerebral palsy or stroke. 34 participants will be randomly assigned to receive…

This pilot study investigates whether children with cerebral palsy walk differently in a gait lab compared to daily life. Researchers think that being watched (the Hawthorne effect) and the absence of everyday distractions (dual-tasks) may cause lab results to be misleading. By t…

This study is looking at whether the brains and spinal cords of adults with cerebral palsy shrink or change over time, which might explain why some people lose function as they age. Researchers will collect and compare past and new MRI scans from 30 adults with CP across the U.S.…

This study looks at how muscles grow and change in children with cerebral palsy (CP) by examining tiny samples from leg muscles. Researchers will compare these microscopic findings with muscle images and movement tests. The goal is to better understand why muscles in CP develop d…

This study looks at muscle problems, metabolic issues, and chronic inflammation in adolescents and young adults (ages 14-30) with moderate to severe spastic cerebral palsy. Researchers will compare them to less affected and healthy peers, then have the more affected group do a 12…

This study looks at how botulinum toxin (Botox) injections change muscle structure in children with spastic cerebral palsy. Using advanced imaging like MRI and 3D ultrasound, researchers will measure muscle size, fat content, and stiffness in 51 children. The goal is to understan…

This study looks at 72 children aged 5 to 8 with hemiplegic cerebral palsy to see how well they can use their affected arm and how that relates to their participation in everyday activities. Researchers will measure arm movement quality and compare it to how much the children tak…

This study looks at how a 2-week, personalized therapy program helps children aged 4-12 with conditions like cerebral palsy, autism, or genetic disorders. Kids get about 2.5 hours of tailored therapy each day, focusing on skills like movement, attention, and communication. The go…

This study looks at how ankle-foot orthoses (AFOs) change the way leg muscles work in 30 children with cerebral palsy (ages 6–17). Researchers will measure muscle activity while children walk barefoot and with their prescribed AFO, both on a treadmill and overground. The goal is …

This study aims to understand how muscles change over time in children with spastic cerebral palsy. Researchers will use 3D ultrasound to measure muscle size, length, and quality in 229 children. The goal is to link these changes to brain injury and treatments, helping improve fu…

This study looks at children with spastic cerebral palsy to see if ultrasound images of their muscles can predict how well they can move. Researchers will measure muscle thickness, stiffness, and blood flow, and compare these to standard tests of motor function. The goal is to fi…

This study is working to create better methods for evaluating how children with and without stroke or cerebral palsy use their arms and hands. Researchers will observe 80 children, including those with perinatal stroke and typically developing infants, using video and play-based …

This study looks at whether a child's ability to imagine movements is connected to how well they walk, balance, and move in daily life. Researchers will test 99 children with diplegic cerebral palsy aged 5 to 18. No treatment is given; the goal is simply to understand the relatio…