Sexually transmitted disease

This study tested an experimental gonorrhea vaccine in healthy adults aged 18 to 50. The goal was to see if the vaccine is safe and can prevent gonorrhea infections. Over 1,000 participants received either the vaccine or a placebo (salt water shot) and were monitored for side eff…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This trial compares two surgical methods—carbon dioxide laser ablation and electrocoagulation—for removing genital warts in women. The main goal is to see which technique gives a better cosmetic result six weeks after treatment. Researchers also track operation time, complication…

This study tests whether giving menstrual cups to economically vulnerable women in Kenya can lower rates of bacterial vaginosis (BV) and sexually transmitted infections (STIs). The cup is a reusable silicone device that collects menstrual blood and can be worn during sex. Researc…

This study tests an experimental vaginal insert (ABI-2280) to see if it can safely clear persistent high-risk human papillomavirus (HPV) infection in women aged 25 to 55. Participants must have had HPV for at least a year with no serious cervical changes. The study compares diffe…

This trial tests a community-based approach to HIV prevention for young people aged 15-30 in rural KwaZulu-Natal, South Africa. Peer navigators guide participants to mobile clinics that offer sexual health services, including HIV testing, PrEP, and contraception. The goal is to r…

This study tested whether kudzu, an herbal supplement, can help people who binge drink reduce their alcohol use and related risky sexual behaviors. Researchers enrolled 120 sexually active adults who binge drink and are at high risk for HIV. Participants received either kudzu or …

This study tested a program to help men who have sex with men (MSM) stay on daily PrEP (a pill that prevents HIV) and reduce sexually transmitted infections (STIs). 240 men in Atlanta used a mobile app that flagged when they might stop PrEP, then a peer counselor and doctor stepp…

This study tested three football-based programs for teen girls in Zambia to improve HIV testing, birth control use, and mental health. Over 2,100 girls from 32 schools took part. The programs aimed to make it easier for girls to get sexual health services and stick with HIV treat…

This study tested a new synthetic nitrile condom against a standard latex condom in 305 couples. Each couple used both types five times to see how often they broke or slipped. The goal was to see if the new condom works as well as latex for preventing sexually transmitted disease…

This study tested a rapid fingerstick test that checks for both HIV and syphilis at the same time in pregnant women visiting prenatal clinics in Guatemala. The goal was to see if this quick, on-the-spot screening would lead to more women being diagnosed and treated during pregnan…

This study evaluates a disposable, at-home PCR test that detects chlamydia and gonorrhea from a urine sample. Men aged 14 and older collect their own sample and use the test with app or written instructions. The goal is to see if the test works accurately outside a clinic, potent…

This study compares a new rapid point-of-care test for chlamydia, gonorrhea, and mycoplasma genitalium to standard lab testing. The goal is to see if the faster test helps doctors give the right antibiotics on the same day, reducing unnecessary or missed treatments. Participants …

This study tested three rapid, point-of-care HIV tests to see how well they work compared to standard lab tests. Researchers enrolled 224 adults at high risk for HIV in Baltimore. The goal was to see if faster results help more people start treatment or prevention the same day.

This study looked at better ways to screen teenagers (ages 15-21) for chlamydia and gonorrhea when they visit emergency departments. Researchers compared offering STI tests to everyone versus only to those with certain risk factors. The goal was to find the most effective and cos…

This study tested a strategy of using rapid, point-of-care diagnostic tests for sexually transmitted infections (STIs) in pregnant women attending antenatal clinics in Zimbabwe. Over 1,000 women were offered testing for chlamydia, gonorrhea, trichomoniasis, syphilis, and hepatiti…

This study tested whether a rapid 30-minute desktop test for gonorrhea and chlamydia could help doctors make better treatment decisions compared to the current standard (a gram stain). 98 adults with symptoms of urethritis or cervicitis took part. The goal was to see if the rapid…

This study tests a program called Treat4All that helps people who drink heavily and are at risk for HIV or already have HIV. About 160 adults from an STI clinic in Lilongwe, Malawi, will either get the program or usual care. The goal is to see if the program reduces heavy drinkin…

This study tests whether a single counseling session aimed at reducing stigma can help Black men who have sex with men and use substances stay on PrEP, a daily pill that prevents HIV. Participants receive the counseling and are monitored for PrEP adherence through biological test…

This trial tests a workshop called Floreciendo, designed for Latina teens aged 14-18 and their female caregivers. The workshop covers sexual health basics, condoms and contraception, family communication, and gender relationships. The study aims to see if the program is feasible …

This trial tests a tablet-based decision support tool designed to help women learn about their HIV risk and prevention options, including PrEP. Women aged 18-45 who are not living with HIV will be randomly assigned to use the tool before a clinic visit or to receive standard coun…

This study compares different ways of screening pregnant women for three common sexually transmitted infections (chlamydia, gonorrhea, and trichomonas) to see if treating these infections can reduce the risk of preterm birth and low birth weight. Over 2,200 pregnant women in Sout…

This pilot study tested whether offering sexual health services like HIV prevention pills (PrEP), STI testing, and birth control in hair salons could reach women who might not visit a clinic. About 436 women in Umlazi, South Africa, took part. Some salons offered these services, …

This study tested whether a mobile app (GeoPassport), financial incentives, and peer mentor support could help men who have sex with men and transgender women leaving jail access HIV prevention services like PrEP and testing. 233 participants were enrolled and followed for 9 mont…

This pilot study tested whether taking doxycycline once a week can prevent bacterial sexually transmitted infections (STIs) in cisgender women who are already taking HIV PrEP. Sixty women in Kisumu, Kenya, received the antibiotic weekly under direct observation for six months. Th…

This study tested two HIV prevention programs for African immigrant women: one-on-one counseling (Dada Kwa Dada) and group sessions (DADA). The goal was to see which approach increases condom use and PrEP uptake. 149 HIV-negative women from the Boston and New York areas took part…

This study tested a program called HUG-M+ designed to help young Thai men who have sex with men get tested for HIV and reduce risky behaviors. Over 600 men aged 15-29 took part in two cities, one receiving the program and the other standard care. The goal was to see if the progra…

This study tested whether a program designed specifically for women who use drugs could help them reduce their risk of HIV and other sexually transmitted diseases. 501 women were randomly assigned to receive either standard counseling, standard counseling plus a well-woman exam, …

This study tested whether a personal helper (a systems navigator) could help heterosexual men in Malawi keep taking HIV prevention medication (PrEP). 199 men who were getting care for sexually transmitted infections took part. The navigator provided support and reminders to help …

This pilot study tested whether a couples-based counseling program could help young people (ages 16-25) and their partners prevent STIs and HIV. The program added joint health education sessions to existing individual prevention counseling. Researchers enrolled 68 participants fr…

This study tested a tablet-based tool and clinic training to help women learn about HIV prevention, including PrEP. 141 women from a Florida clinic participated. The goal was to see if these tools helped women make informed choices and start prevention methods.

This study tested an online program called itMatters designed to reduce sexually transmitted infections (STIs) among college students. The program focuses on the link between drinking alcohol and risky sexual behavior, such as not using condoms. Over 3,000 first-year students fro…

This completed trial tested a digital program called LuvHub for male couples. The program includes modules on HIV/STI prevention, communication, and relationship goals. Over 16 months, 778 couples used the tool to create personalized prevention plans and agreements. The study mea…

This study looked at whether offering HIV prevention services, including PrEP medication, in family planning clinics helps more young women get tested for HIV and start PrEP. Over 25,000 sexually active, HIV-negative young women in Kenya took part. The goal was to see if integrat…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This observational study measures how often HPV infections and other sexually transmitted infections occur in transgender adults. Researchers will check for HPV at genital, anal, and oral sites, and also look for anal dysplasia, which can be a precursor to cancer. The study inclu…

This study will give 100 migrant women in Turkey three structured training sessions on sexually transmitted infections, self-efficacy, and reproductive autonomy. Researchers will measure changes in knowledge, confidence, and decision-making compared to a control group. The goal i…

This study tested two peer education programs to see which better improves nursing students' knowledge, attitudes, and behaviors about sexually transmitted infections (STIs). Thirty-six first-year nursing students were split into two groups: one received a program based on a beha…

This study looked at how much doxycycline builds up in body tissues after taking it daily for 7 days. Researchers measured levels in rectal and vaginal tissues to help design better ways to prevent bacterial sexually transmitted infections (STIs). 24 healthy adults took part, inc…

This study followed 450 transgender people (300 HIV-negative and 150 living with HIV) from community health centers in Thailand, Vietnam, and the Philippines for 24 months. Researchers tracked new HIV infections, mental health, and social factors like stigma and violence using su…

This study measured how common Mycoplasma genitalium (MG) infection is among HIV-positive men in Hong Kong and checked for antibiotic resistance. Researchers collected samples from 573 men attending an HIV clinic. The goal was to understand the spread of MG and whether common ant…

This study tested two digital programs for parents of children aged 3-7 with behavior problems. Both programs had the same core content, but one included extra features like reminders and progress tracking. Researchers wanted to see if these extras helped parents stick with the p…

This study asked 36 women about their opinions and use of vaginal products designed to prevent HIV and other sexually transmitted infections. Participants completed questionnaires about their sexual behavior and how often they would use such products. The goal was to gather insig…

This completed study offered free rapid testing for HIV, syphilis, and hepatitis B and C to Ukrainian refugees in Bratislava, Slovakia. Over 660 adults were tested at a health center and a community health day. The goal was to measure how common these infections are in this migra…

This study asked 32 men and women about their experiences using different microbicide suppositories and gels during sex. Participants rated things like how smooth, wet, or messy the products felt. The goal was to better understand what people like and dislike, which can help desi…

This study involved 18 men and women who used three different rectal products (a gel, a cream, and a liquid) during anal sex and then rated their experience. The goal was to develop a questionnaire that captures how these products feel—like wetness, messiness, and pleasure—to hel…

This study tested a training program for family medicine doctors in Alabama to help them talk about HIV and STI prevention with teenage girls and young women. 46 doctors took part and completed surveys before and after training to see if their knowledge and practices changed. The…

This study tested whether a pay-it-forward approach—where one person's donation covers testing for the next person—could increase gonorrhea and chlamydia testing among men in China. Over 1,200 men who had sex in the past year but hadn't been tested recently took part. The goal wa…

This study followed 603 pregnant women in South Africa to see if infections or bacteria in the vagina are linked to how early they give birth. Researchers tested for sexually transmitted infections, yeast, and other germs at the start of pregnancy and again at 30-34 weeks. The go…

This study tested how different doses of the antibiotic doxycycline reach tissues in the body. The goal is to combine it with HIV drugs into a single pill that could be taken just before sex to protect against both HIV and other sexually transmitted infections. 45 healthy adults …

This study tested how acceptable HIV pre-exposure prophylaxis (PrEP) is among men who have sex with men and transgender individuals who agreed to HIV/STI testing through a community-based outreach program, both online and in person. Researchers recruited 209 participants via a ge…

This completed study in France looked at 248 people taking PrEP (a daily pill to prevent HIV) to see how their sexual behaviors and rates of other sexually transmitted infections (STIs) changed over time. Researchers compared those on PrEP for over a year to those on it for less …