Pulmonary arterial hypertension

This early-stage trial tests whether transplanting gut bacteria from healthy donors, along with antibiotics and fiber, is safe and feasible for people with pulmonary arterial hypertension (PAH), a condition of high blood pressure in the lungs. About 24 adults with PAH will be ran…

This trial tests whether adults with pulmonary arterial hypertension (PAH) can safely switch from selexipag, a pill taken by mouth, to LIQ861, an inhaled form of treprostinil. Participants stop selexipag on day one and start taking LIQ861 four times a day using a handheld inhaler…

This trial tests whether an experimental drug called CS1, taken as a daily pill, can improve blood vessel function in people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes the heart work harder. Participants will receive CS1 o…

This study tests the safety of a new medicine called sotatercept for adults in India with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs become narrow, making breathing hard. About 30 people will receive sotatercept along with their usual trea…

This trial investigates whether semaglutide, a GLP-1 agonist, can shift how the heart produces energy in people with pulmonary arterial hypertension (PAH). The heart in PAH often relies on inefficient fuel sources, and the drug may help it switch to a more efficient form. Researc…

This registry follows adults newly diagnosed with pulmonary arterial hypertension (PAH) who are starting treatment with parenteral treprostinil, a medication given as a continuous infusion under the skin or into a vein. Researchers will collect data from routine care—including do…

This study tests whether people with pulmonary arterial hypertension (PAH) who are doing well on the drug sotatercept can safely stop their background prostacyclin therapy. Prostacyclin drugs can cause side effects and are hard to manage. The trial compares patients who slowly st…

This study tests whether a specially formulated omega-3 supplement, with a high ratio of EPA to DHA, can reduce inflammation and improve blood vessel function in people with pulmonary arterial hypertension (PAH). Participants take four capsules daily for 12 weeks alongside their …

This trial will compare three drugs—dopamine, norepinephrine, and epinephrine—to see which works best for people experiencing a pulmonary hypertensive crisis, a life-threatening spike in blood pressure in the lungs. The study will enroll 75 adults with pulmonary arterial hyperten…

This study tests whether a 12-week tele-pulmonary rehabilitation program, done at home via an app with a physiotherapist, helps people with chronic lung diseases start and stick with rehab better than going to a center. 90 patients will be randomly assigned to either remote rehab…

This phase 2 trial tests a dietary supplement called 2-HOBA in 12 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs strains the heart. Participants take the supplement three times daily for 12 weeks. The study checks if 2-HOBA i…

This study tests the safety and tolerability of sotatercept in Japanese children aged 1 to 18 with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs narrow, making the heart work harder. Participants receive sotatercept injections every three wee…

This study is checking the long-term safety of a daily pill called IKT-001 for people with pulmonary arterial hypertension (PAH), a serious lung condition. About 484 adults who have already completed an earlier IKT-001 study will take the drug for an extended period. Researchers …

This Phase 3 study tests VI-0106, an extended-release form of tacrolimus, in 300 people with pulmonary arterial hypertension (PAH) who still have trouble with daily activities despite taking standard PAH medications. Participants will receive either the drug or a placebo for 24 w…

This phase 2 trial tests whether adding tiprelestat (elafin) to standard care improves blood flow in the lungs for people with pulmonary arterial hypertension (PAH). About 90 adults with moderate to severe PAH will receive either a daily injection of tiprelestat or a placebo for …

This study tests a drug called sotatercept in 40 adults with congenital heart disease and Eisenmenger syndrome, a serious condition where blood flow in the lungs is blocked. The drug is given as a shot every three weeks for 24 weeks. The goal is to see if it safely lowers pressur…

This study will test whether the drug sotatercept can reverse damage to the lung's blood vessels in people with pulmonary arterial hypertension (PAH). Researchers will use special imaging techniques to look inside the arteries and see if they become healthier over 9 months. The s…

This study looks at how well the oral medication selexipag works over the long term for people with a specific type of lung hypertension caused by schistosomiasis (a parasitic infection). Researchers will compare patients who received selexipag as part of routine care to similar …

This Phase 2 trial tests an oral drug called NS-863 in 135 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe. Participants will receive either a low dose, high dose, or placebo for 24 weeks. The main goa…

This early study tests a single dose of stem cells (PNEUMOSTEM®) given into the windpipe of very premature babies with high blood pressure in their lungs. The goal is to see if it is safe and might improve breathing, reduce time on a ventilator, and lower the need for oxygen. Onl…

This phase 2 trial tests whether a triple combination of three drugs—sotatercept, an endothelin receptor antagonist, and a phosphodiesterase-5 inhibitor—can improve blood flow in the lungs of people newly diagnosed with pulmonary arterial hypertension (PAH). The study will enroll…

This study tests whether adding an injectable medication called treprostinil to standard oral therapy can improve heart function in people with intermediate-risk pulmonary arterial hypertension (PAH). About 32 adults will receive the drug for 3 months, with heart scans and walkin…

This study follows 32 adults with pulmonary arterial hypertension (PAH) whose doctors decide to switch them from inhaled iloprost (taken several times a day) to oral selexipag (a pill). Researchers will use questionnaires to see if the switch improves quality of life, treatment s…

This study is creating a large collection of blood samples and medical information from 1000 adults with or suspected of having pulmonary hypertension (PH). Researchers hope this resource will help them find new ways to diagnose and treat PH. Participants will provide a blood sam…

This study looks at whether environmental toxins, drugs, and workplace exposures play a role in causing pulmonary arterial hypertension (PAH), a rare and serious lung condition. Researchers will compare 150 newly diagnosed patients with PAH to those with another form of pulmonary…

This study looks at how tiny particles called extracellular vesicles travel through the bloodstream in people with systemic sclerosis, an autoimmune disease that affects blood vessels and organs. Researchers will take blood samples from different points in the circulation to see …

This study looks at how well the right side of the heart works with the lungs in people who have high blood pressure in their lung arteries caused by schistosomiasis, a parasitic infection common in parts of Africa and South America. Researchers will use echocardiography to measu…

This study will look at 60 adults with a type of high blood pressure in the lungs (pre-capillary pulmonary hypertension) to see if measurements from a CT scan match those from a standard invasive heart catheter test. If the CT scan proves reliable, it could offer a safer, less in…

This pilot study will use special PET/CT scans to see how the experimental drug sotatercept affects blood vessel remodeling in the lungs and heart of people with pulmonary arterial hypertension (PAH). About 15 adults with PAH will receive sotatercept and have imaging at the start…

This study looks at whether mindfulness-based stress reduction can help Black teenage girls who have been involved with the justice system and their parents or caregivers. About 90 participants will report on stress, PTSD symptoms, and other outcomes before and after the program.…

This study looks at whether placing patients face-down (prone) soon after heart surgery can improve how well the right side of the heart works. The idea is that this position helps open up collapsed parts of the lungs, making it easier for the heart to pump blood. About 80 adults…

This study will create and test a new questionnaire to measure quality of life in Chinese patients with pulmonary arterial hypertension (PAH), a serious lung condition. Researchers will work with 300 adults to ensure the tool is accurate and useful for doctors and health policy. …

This study follows 60 adults with pulmonary hypertension (high blood pressure in the lungs) for 2 years. Researchers will measure breathing problems during sleep and heart rate changes to see how they relate to the disease. No new treatment is given; participants continue their u…

This study looks at how changes in the cells lining blood vessels relate to lung resistance in people with pulmonary artery hypertension (PAH). Researchers will measure certain blood markers and lung pressure in 6 adults with PAH. The goal is to better understand the disease, not…

This study looks at whether different types of exercise (like walking or strength moves) and timing (morning vs. evening) can safely lower blood pressure in people with glaucoma and high blood pressure. About 60 adults will try four exercise sessions, and their blood pressure and…

This observational study will review medical records of 15 adults with pulmonary arterial hypertension (PAH) who switched from one medication (a PDE5 inhibitor) to riociguat while already on triple therapy. The goal is to see if this switch improves exercise ability, symptoms, an…

This study aims to find genetic variants that may explain why some people with a rare liver bypass condition (congenital portosystemic shunt) develop a serious lung complication called portopulmonary hypertension. Researchers will analyze blood samples from 120 patients and their…

This study will follow 200 adults with pulmonary arterial hypertension who experience a sudden worsening of right heart failure. Researchers will collect medical data to see how many survive or need a lung transplant within 3 and 12 months. The goal is to identify better ways to …

This study uses a short questionnaire to learn where patients with pulmonary hypertension and their caregivers search for health information, what topics they look for, how satisfied they are, and which sources they trust most. Researchers will enroll 100 adults in Brazil. The go…