Osteoarthritis, hip

This study tests whether a supervised resistance exercise program, done for 2 weeks before and 12 weeks after total hip replacement, improves muscle mass and strength in adults aged 60 and older with severe hip osteoarthritis. Participants are randomly assigned to either the exer…

This study will test a new cementless hip stem (Mfinity collared stem) in 95 adults needing total hip replacement due to osteoarthritis. The main goal is to see how many implants survive without needing revision after one year, with a follow-up at two years. Researchers will trac…

This study tests an experimental injection called TG-C for people with early hip osteoarthritis. The injection contains cells that release a growth factor to help repair damaged cartilage. 255 adults will receive either TG-C or a placebo, and researchers will track pain and hip f…

This study will follow 100 adults who receive the 5C® MEDic Knee System during knee replacement surgery. Researchers want to see how long the implant lasts without needing another operation and track any complications over 5 years. Participants will also fill out health questionn…

This study tests a new CT scan technique to see if it can accurately detect loose hip implants before revision surgery. 600 patients scheduled for hip replacement revision will get the special CT scan, and the results will be compared to what the surgeon finds during the actual o…

This study compares two ways to diagnose bleeding problems during surgery: a quick bedside test (viscoelastic test) and standard lab tests. The goal is to see which method gives faster results, helping doctors treat bleeding sooner. About 210 adults having high-risk surgeries (li…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study looks at a personalized plan to help older adults prevent falls. It includes 50 people aged 65 or older who have sarcopenia (muscle loss) and knee or hip arthritis. Researchers will test balance, strength, and range of motion to create a tailored fall prevention strate…

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This study tests whether a single injection of concentrated bone marrow cells can reduce pain and improve function in people with hip osteoarthritis better than a standard steroid injection. One hundred adults with moderate to severe hip arthritis will be randomly assigned to rec…

This study compares two ways to perform total hip replacement: the standard direct lateral approach and a newer, less invasive method called SuperPATH. Researchers want to see if SuperPATH reduces pain, blood loss, and recovery time while improving joint stability. 100 adults nee…

This study compares two spinal anesthetics, ropivacaine and bupivacaine, in 176 people having hip replacement surgery. The goal is to see which one allows faster return of feeling and movement while still controlling pain well enough for same-day discharge.

This study tests whether adding high-intensity pulsed electromagnetic field (HI-PEMF) therapy to standard exercise can reduce pain and improve daily function in people who have had a total hip replacement. Forty adults who had hip replacement due to osteoarthritis will receive ei…

This study looks at three different ways to manage pain during and after hip replacement surgery in people aged 60 and older. All participants will get spinal anesthesia, but some will also get a nerve block around the hip joint, with or without an extra anti-inflammatory drug. T…

This study looks at whether a well-formulated ketogenic diet can reduce pain and improve thinking in adults with osteoarthritis and mild cognitive impairment. Ten participants will follow a supervised low-carb, high-fat diet for a period, with before-and-after tests for pain, phy…

This study tests a pain-relief method called cryoneurolysis, which uses cold to temporarily freeze nerves, for people waiting months for hip or knee replacement surgery. The goal is to reduce pain and the need for opioid painkillers, which can be risky if used long-term. Research…

This study tests whether gently rocking in a chair three times a day for 30 minutes helps people aged 65 and older recover after hip replacement surgery. Sixty participants will be randomly assigned to either rock or sit still in a chair. Researchers will measure how many people …

This study looks at whether adding a nerve block to the back of the hip to two standard front-hip blocks can improve pain relief after hip surgery. About 50 adults having hip surgery will be split into two groups to compare pain scores and the need for extra pain medicine in the …

This study looks at whether a smartphone app that teaches cognitive behavioral therapy can help young adults (ages 15-39) with hip pain feel less depressed, anxious, and stressed. Researchers will also measure pain, physical function, and opioid use. Half of the 150 participants …

This study tests whether taking tranexamic acid pills for a week after knee replacement surgery helps people recover better. 350 adults having their first knee replacement will receive either the drug or a placebo. Researchers will track pain, stiffness, and function for up to 2 …

This study looks at whether injecting platelet-rich plasma (PRP) into the sacroiliac joint after hip replacement surgery can help people recover faster and have less pain. About 60 adults with hip arthritis who are scheduled for a hip replacement will take part. Half will get the…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This pilot study tests whether getting extra sleep (sleep banking) before knee or hip replacement surgery can help reduce chronic pain and the need for painkillers after the operation. Researchers will enroll 22 adults aged 18-74 scheduled for joint replacement at a Navy medical …

This study looks at whether using a device called the Alexis wound retractor during hip replacement surgery helps wounds heal faster and reduces infections. About 202 adults with hip arthritis having a first-time hip replacement will take part. Researchers will compare healing, s…

This study tests whether using ultrasound therapy before a steroid injection into the joint can improve pain and swelling for people with arthritis. About 100 adults with arthritis in their arms or legs will receive the combined treatment. The goal is to see if the ultrasound hel…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study compares general anesthesia (being fully asleep) with spinal anesthesia (numbing the lower body) in 600 adults having knee or hip replacement as outpatient surgery. The goal is to see which method leads to successful same-day discharge without readmission. Researchers …

This study tests a gel called Sensovisc, made of sodium hyaluronate, injected into the hip joint to relieve pain from osteoarthritis. The gel aims to restore the joint's natural fluid, reducing pain and improving movement. Researchers will track 25 adults with moderate hip arthri…

This study tests whether virtual lifestyle-focused pain care works as well as in-person care for adults with chronic back, knee, or hip pain living in rural areas. Participants will receive up to 10 sessions over six months, either in-person with a physiotherapist or virtually wi…

This study will follow about 950 people who receive hip or knee replacements using Stryker implants, some with the Mako robotic-arm system and some without. Researchers will track how long the implants last and how well patients feel and function over five years. The goal is to g…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study follows 60 adults getting hip or knee replacement to track their sleep before and up to 6 months after surgery. Participants use a special device and app to measure sleep quality, pain, and recovery. The goal is to learn when sleep returns to normal so doctors can give…

This study will follow 200 people who have had a complex or revision hip replacement at University Hospitals Leuven. The goal is to track how many need another surgery and why, and to improve care by learning from real-world results. No new treatment is being tested—this is an ob…

This study will use DEXA bone scans to see how the CoreHip hip replacement stem affects bone density around the implant over two years. Forty adults with hip arthritis or other hip conditions will be enrolled. The goal is to understand if the implant's design helps maintain healt…

This study at Montpellier University Hospital will look at whether low muscle mass and strength before hip replacement surgery affects how well people aged 75 and older regain their independence. About 20 volunteers will have blood tests, scans, and a tiny muscle sample taken dur…

This study aims to see if a submaximal bike test, called the Ekblom-Bak test, gives consistent results when repeated in people with hip or knee osteoarthritis. Forty patients will take the test twice, one to two weeks apart. The goal is to determine if this test can be reliably u…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study examines how much the tensor fascia latae muscle is damaged during hip replacement surgery through the front approach. Researchers will compare the amount of muscle damage to how well patients recover at 6 weeks and 6 months. The goal is to understand if less muscle da…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…