Osteoarthritis

This study tests whether a single injection of Axolotl Ambient, a fluid rich in growth factors derived from human amniotic cells, can reduce pain and improve function in people with ankle osteoarthritis. Participants will be randomly assigned to receive either the investigational…

This study is testing a new thumb implant called the InDx CMC Implant for people with thumb arthritis. The implant replaces part of the thumb joint to improve hand function and reduce pain. Researchers will track safety and how well the implant works in 73 adults over time.

This study tests whether a drug called amobarbital, injected into the ankle joint during fracture repair surgery, can prevent post-traumatic osteoarthritis. The trial involves 5 adults aged 18–60 with severe ankle fractures. The main goal is to check safety, but researchers will …

This study followed 65 adults with ankle arthritis (from wear-and-tear, injury, or conditions like rheumatoid arthritis) who received the Cadence Total Ankle System implant. Researchers tracked how long the implant lasted without needing removal or revision, checking at 2, 5, and…

This study tested a special bone graft material (MatriBONE mixed with the patient's own bone marrow) for spinal fusion surgery in people with painful degenerative back problems. The goal was to see how well the bones fused together after 12 months. However, the trial was stopped …

This study looked at a shoulder implant used to treat pain and joint problems from conditions like arthritis, fractures, and rotator cuff tears. It involved 67 adults who received the implant and tracked how long it lasted and any side effects over 10 years. The goal was to confi…

This study tested a treatment called Chondron, made from a patient's own cartilage cells, for repairing ankle cartilage defects. The trial aimed to see if the treatment could improve cartilage quality and ankle function over 18 months. However, the study was terminated early and …

This study tested an experimental drug called LNA043, given as injections into the knee, to see if it could slow cartilage loss and reduce pain in people with knee osteoarthritis. The trial planned to follow 576 participants for up to 5 years, but it was terminated early. The mai…

This study tested a drug called lorecivivint, given as a knee injection, to see if it could safely slow knee osteoarthritis and improve pain and function over two years. It enrolled 276 people who had already completed an earlier study. The trial was terminated early, so the full…

This study looked at the TITAN Reverse Shoulder System, a device used to replace the shoulder joint in people with severe arthritis and a torn rotator cuff. The goal was to see if it relieves pain and improves movement. About 151 people were planned to take part, but the study wa…

This small, early-phase study tested a single injection of lorecivivint into the knee joint of 13 people with moderate-to-severe knee osteoarthritis. The goal was to see if the drug could slow cartilage loss, measured by MRI scans. The trial was terminated early, so the results a…

This study tested whether injecting a person's own fat-derived stem cells into arthritic joints could safely reduce pain and improve movement. Only 14 people with osteoarthritis of the knee, hip, ankle, shoulder, or wrist took part before the study was stopped early. The results …

This study looked at how well a custom knee replacement system worked for people with knee osteoarthritis. Researchers tracked complications in 52 adults who had the surgery. The study was stopped early, so results are limited.

This study aimed to develop a biomarker test using blood or joint fluid to detect tissue damage (necrosis) caused by metal-on-metal hip implants. Researchers planned to enroll 174 patients, including those needing revision surgery and a control group. The goal was to see if the t…

This study tested whether gloves with tiny semiconductors embedded in the fabric could reduce pain and improve hand function in people with hand osteoarthritis. Sixteen participants wore either the active gloves or identical-looking placebo gloves. The trial was terminated early,…

This study looked at three treatments for thumb base arthritis: a platelet-rich plasma (PRP) injection, a corticosteroid (Kenalog) injection, or a placebo (saline) injection. The goal was to see which best improved hand function and pain. The trial enrolled 74 people with early-s…

This study looked at whether adding a nerve block (adductor canal block) to a standard pain injection around the knee provides extra pain relief for people having total knee replacement. About 93 adults with osteoarthritis participated. The goal was to find the best way to manage…

This study tested an investigational drug called QUC398 in 101 people with painful knee osteoarthritis. Participants received either QUC398 injections or a placebo. The goal was to see if the drug could reduce knee pain and improve cartilage health. The trial was terminated early…

This study tested an injection called lorecivivint for people with knee osteoarthritis. The goal was to see if it safely reduces pain and improves knee function over three years. The study was stopped early and included 72 adults aged 40 to 80.

This early-stage study aimed to see if a concentrated dose of a person's own bone marrow cells, given during shoulder surgery, is safe for treating painful shoulder arthritis. Only 2 people aged 50 or older took part before the study was stopped. The main goal was to check for si…

This study tested whether low level laser therapy (LLLT) could reduce pain and improve hand function in people with hand osteoarthritis. About 83 military members and their families received either real or sham laser treatment weekly for six weeks. The trial was terminated early,…

This study compares a new minimally invasive procedure called genicular artery embolization (GAE) to standard steroid injections for reducing knee pain from osteoarthritis. It was designed for adults over 40 whose knee pain hasn't improved with other treatments. The goal is to se…

This study tested an experimental drug called GSK3858279 in 314 adults with moderate to severe knee osteoarthritis pain. The goal was to find the best dose that reduces pain safely. However, the trial was stopped early, so we have less information than planned.

This study tested a temporary peripheral nerve stimulation system (SPRINT PNS) placed near the knee for up to 60 days to relieve chronic pain from osteoarthritis. Only 12 people were enrolled, and the trial was terminated early. Researchers measured pain intensity, quality of lif…

This study tested two injected drugs, canakinumab and LNA043, for people with painful knee osteoarthritis. It aimed to see if they could reduce pain and improve cartilage. The trial was stopped early and included only 23 participants, so results are limited.

This study tested whether changes in pupil size can reliably measure pain. Twenty adults with hip or knee arthritis received brief heat pulses while researchers recorded their pupil responses and pain ratings. The goal was to see if pupil diameter could serve as an objective pain…

This study looked at whether people with nickel allergy do better with special nickel-free knee implants. Researchers compared standard implants to nickel-free ones in 9 patients with self-reported nickel sensitivity. The goal was to see if nickel allergy affects pain, function, …

This study aimed to see if using a patient's healthy knee as a guide for aligning a new knee joint during replacement surgery leads to better results than the standard method. Researchers planned to compare two groups of people with arthritis in one knee, using CT scans to plan t…

This study looked at two different ways surgeons place the top part of a reverse shoulder replacement: sitting on top of the bone (onlay) or set into the bone (inlay). The goal was to see if one method leads to better arm movement after surgery. The study enrolled 19 people with …

This study looked at a specific hip implant shell (the Pinnacle Acetabular Shell) used in total hip replacement. Researchers wanted to see how much the implant moved (migrated) over two years using a special X-ray technique called RSA. They also tracked how patients felt and func…

This study looked at whether custom-made knee implants (ConforMIS iTotal) help people move better than standard off-the-shelf implants after knee replacement surgery. About 215 adults with osteoarthritis took part. Researchers measured walking, daily activities, and sports perfor…

This study looked at how JAK-STAT inhibitors, a type of drug used for rheumatoid arthritis, affect certain immune cells called regulatory B cells. Researchers analyzed blood samples from 27 patients to see if these drugs could boost anti-inflammatory functions. The study was term…