Mononeuropathy

This phase 2 trial tests whether tesamorelin, a daily self-injected drug, can speed nerve regrowth and reduce muscle loss after surgical repair of injured nerves in the arm. 36 adults with a cut ulnar nerve at the wrist will be randomly assigned to receive tesamorelin or no addit…

This study compares two treatments for long blockages (15-25 cm) in the leg's main artery. One is bypass surgery, which uses a vein or artificial tube to reroute blood flow. The other is a less invasive procedure using a balloon to open the artery, often with a stent. The trial w…

This study is testing whether a new approach—using ultrasound to guide a tiny needle to collect fluid near the ulnar nerve, then analyzing it for leprosy bacteria DNA—can more accurately diagnose leprosy and confirm when it's cured. Researchers will follow 108 participants for on…

This study looks at whether a simple ultrasound scan can accurately detect damage to the radial nerve in people with a broken upper arm bone. Some of these patients also have wrist or hand weakness. Researchers will compare ultrasound results with what surgeons find during the op…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose isolated dystonia, a movement disorder. The trial will enroll 1000 people with dystonia or other conditions that look like it, such as Parkinson's disease or ess…

This study tests a new way to measure sciatic nerve stiffness using ultrasound (shear wave elastography) during leg movements. Researchers will compare 30 people with low back pain and sciatica to 30 healthy volunteers. The goal is to see if nerve stiffness differs between the gr…

This study tests a device called Walkasins, worn on the lower legs, that vibrates to give sensory feedback about foot pressure. The goal is to see if using it daily for six months improves balance and walking in 200 adults aged 55+ with peripheral neuropathy. Participants will do…

This study tests whether describing a common pain shot (epidural steroid injection) in a very positive way helps reduce leg pain more than a neutral description. Researchers will compare three groups: positive framing of the shot, neutral framing of the shot, and neutral framing …

This trial tests a wearable robot called ENMS-BSF that combines soft muscles, electrical stimulation, and balance feedback to correct foot drop and foot inversion after a stroke. Sixty people who had a stroke at least six months ago and have mild-to-moderate walking problems will…

This study compares two types of nerve-stretching exercises (tensioner and slider) for people with sciatica. Eighty participants with leg pain lasting 3 to 12 months will receive one of the techniques plus standard physical therapy. Researchers will measure pain, disability, and …

This study compares a targeted nerve block injection to usual pain treatment for people with sudden sciatica in the emergency department. About 100 adults will be randomly assigned to receive either the nerve block or standard care. Researchers will measure pain levels and walkin…

This study tests whether a common back operation (microdiscectomy) actually relieves sciatica leg pain better than a pretend surgery. 122 adults with a herniated disc and persistent leg pain will be randomly assigned to get either the real operation or a sham procedure. Neither t…

This study tests two stretching techniques—post-isometric relaxation and active isolated stretching—in 40 adults with piriformis syndrome, a condition that causes buttock and hip pain. Over two weeks, participants will receive six sessions of one stretch type plus standard physio…

This study is testing whether combining two types of electrical stimulation can help people who have had a stroke lift their toes while walking. Participants will receive mild electrical currents on their scalp and leg while doing walking exercises. The goal is to see if this com…

This study tests whether a single 30-minute session of electrical nerve stimulation (PENS) can quickly reduce sciatica pain and improve daily function. 88 adults with long-term sciatica will be randomly assigned to receive PENS, TENS (skin patches), dry needling, or a placebo. Re…

This study tests whether a treatment called Percutaneous Electrical Nerve Stimulation (PENS), combined with exercise, can reduce pain and improve quality of life in people with long-term sciatica. 88 adults with chronic leg pain from sciatica will be randomly assigned to receive …

This study tests whether a modified version of the muscle relaxant metaxalone (640 mg) can reduce low back and leg pain in people with acute sciatica or spinal stenosis. Fifty adults aged 18 to 80 with new-onset pain will take either the drug or a placebo for 7 days. Researchers …

This study compares two exercise approaches for dead butt syndrome, a condition where the gluteal muscles become inactive, causing pain and discomfort. Forty participants will be randomly assigned to either gluteal activation exercises alone or combined with core strengthening. T…

This study tests whether adding a specific leg-rotation technique to standard physical therapy can better relieve sciatica caused by disc problems in the lower back. Researchers will measure pain, flexibility, and daily function in 70 adults aged 18 to 50. The goal is to see if t…

This study tests a gentle, hands-on technique called Strain-Counterstrain for people with pain from the piriformis muscle. Thirty adults with a tender spot in that muscle will receive a passive leg maneuver held for 90 seconds. Researchers will measure changes in pain threshold a…

This early study tests a small device that sends gentle electrical pulses to nerves to relieve severe, long-lasting knee, elbow, or shoulder pain. About 30 adults with chronic pain will first try a temporary implant for up to 8 hours. If it works well, they can get a permanent ve…

This early-stage study tests a single injection of C-1101 into the spine area for people with long-term sciatica (leg pain from a pinched nerve). The main goal is to check if the treatment is safe and tolerable compared to a saltwater placebo. Only 24 adults with pain that hasn't…

This study tests if low-level laser therapy can reduce pain and improve quality of life in people with meralgia paresthetica, a condition causing numbness or burning on the outer thigh. About 44 adults will receive either real laser or a sham laser, both combined with TENS (a mil…

This study tests whether giving a mild electrical stimulation to the nerve a week before surgery can improve hand function recovery in people with severe cubital tunnel syndrome. Thirty adults with severe nerve damage will be randomly assigned to receive either real stimulation o…

This study tests whether adding high-power laser therapy to standard care (like lifestyle changes and pain medication) can better relieve pain, tingling, and numbness in people with meralgia paresthetica—a nerve condition causing discomfort in the outer thigh. About 50 adults wit…

This study tests whether pain neuroscience education (PNE) can improve symptoms in people with mild to moderate carpal tunnel syndrome. Participants will receive PNE along with standard home exercises and a wrist splint. The goal is to see if understanding pain better leads to le…

This study tests whether taking ginger root extract daily for 8 weeks can reduce pain and improve gut health in people with chronic sciatica. Researchers will measure pain levels, gut bacteria, and brain changes in 80 adults. The goal is to see if ginger affects the gut-brain con…

This study tests a remote program called Move-MORE for people with sciatica (nerve pain from the lower back into the leg). The program combines mindfulness, gentle movement, and motivational coaching to help manage pain and improve daily function. Researchers will enroll 32 adult…

This study looks at whether kinesio taping, a special elastic tape applied to the elbow, can reduce pain from cubital tunnel syndrome when added to nerve-gliding exercises. About 36 adults with confirmed cubital tunnel syndrome will be split into three groups: exercise only, exer…

This study compares two hands-on techniques—SNAG (a gentle spinal glide) and sciatic nerve mobilization exercises—for easing non-specific sciatica pain. Thirty adults with pain lasting over 12 weeks will try both methods in a crossover design, with each session separated by 10 da…

This study compares two common surgeries for ulnar neuropathy at the elbow: simple decompression and subcutaneous anterior transposition. Researchers will enroll 378 adults with confirmed ulnar nerve issues to see which surgery better improves hand function and reduces pain. Part…

This study checks if a French version of the MEPS/MEPI elbow score works well for children aged 4 to 17. It includes kids with and without elbow injuries to see if the score accurately measures elbow pain and function. The goal is to make sure doctors can use this tool reliably i…

This study looks at how inhaled cannabis affects the brain in people with chronic low back pain. Researchers will use MRI scans to measure changes in brain blood flow and oxygen levels, and ask participants to rate their pain. The goal is to understand the brain mechanisms behind…

This study aims to see if a quick bedside sensory test can predict which painkiller—pregabalin, duloxetine, or a placebo—works best for people with nerve pain in their feet. About 190 adults with diabetic, chemotherapy-related, or idiopathic nerve pain will try each treatment for…

This study looks at how the constant vibration from tattoo machines may damage nerves in the hands of tattoo artists. Researchers will test touch, strength, and sensation in 20 tattoo artists and compare them to 20 people who don't use vibrating tools. The goal is to understand i…

This study is collecting information from 4,000 adults with peripheral neuropathy (nerve damage) to better understand the condition. Researchers will combine standard tests with nerve ultrasound to see if it helps diagnose and track the disease. No new treatments are being tested…

This study looks at why a numbing injection in the thigh (adductor canal block) works so well for knee surgery pain. Researchers think the medicine may spread to the sciatic nerve, but they want to measure how often this happens. About 70 adults having knee surgery will be tested…

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms …

This study is checking whether a common nerve test called needle EMG causes muscle bleeding in people taking blood thinners (DOACs). About 30 minutes after the test, researchers will use ultrasound to look for any small bleeds in the muscles where the needle went in. The goal is …