Mononeuropathy
MONDO:0001397Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ischemia; traumatic injury; compression; connective tissue diseases; cumulative trauma disorders; and other conditions.
102 clinical trials for this condition and its sub-types.
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Broader categories
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New surgical technique aims to restore hand pinch after nerve injury
Disease control OngoingThis study tests a surgical procedure that moves two tendons in the forearm to help people with long-term ulnar nerve damage regain the ability to pinch. 17 adults aged 18-60 with stable joints and no other nerve injuries will be followed for 12 weeks after surgery. The goal is t…
Phase: NA • Sponsor: Sohag University • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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New hope for back pain sufferers: no surgery needed?
Symptom relief OngoingThis study looks at whether a non-surgical treatment called spinal decompression can help people with chronic low back pain. About 42 adults with back pain from disc problems or sciatica will receive the treatment over 12 weeks. Researchers will use MRI scans and movement tests t…
Phase: NA • Sponsor: University of South Florida • Aim: Symptom relief
Last updated Jun 27, 2026 12:34 UTC
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Can remote rehab beat home workouts for piriformis pain?
Symptom relief ENROLLING_BY_INVITATIONThis study compares two exercise programs—asynchronous telerehabilitation (remote guidance) and a standard home exercise plan—for people with piriformis syndrome, a condition causing buttock and leg pain. About 46 adults aged 18-45 with confirmed diagnosis will participate. The g…
Phase: NA • Sponsor: Hacettepe University • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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Could a simple tourniquet change cut Post-Surgery pain and opioid use?
Symptom relief OngoingThis study tests whether using a lower-pressure tourniquet during orthopedic surgeries can reduce pain and the need for opioid painkillers afterward. Standard tourniquets use high pressure, which can cause muscle weakness and pain. The experimental device sets pressure based on t…
Phase: NA • Sponsor: The Methodist Hospital Research Institute • Aim: Symptom relief
Last updated Jun 27, 2026 12:03 UTC
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Massage showdown: which therapy eases piriformis pain best?
Symptom relief ENROLLING_BY_INVITATIONThis study compares two types of hands-on therapy—Stecco Fascial Manipulation and Rolfing Structural Integration—for people with piriformis syndrome, a condition that causes buttock and leg pain. Forty-two adults aged 25 to 45 with at least four weeks of pain will receive four we…
Phase: NA • Sponsor: Danyal Ahmad • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC
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Can herbs and spinal manipulation ease chronic back pain? new study investigates
Symptom relief OngoingThis study looks at whether a combination of herbal medicine and Chuna manual therapy (a Korean spinal manipulation technique) can safely reduce pain and improve walking ability in people with low back pain or sciatica caused by lumbar spinal stenosis or spondylolisthesis. Resear…
Sponsor: Jaseng Medical Foundation • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Simple stretches may ease piriformis pain: new study
Symptom relief OngoingThis study looks at whether adding dynamic stretching to foam rolling helps people with piriformis syndrome more than foam rolling alone. Forty adults aged 35–50 with buttock pain will do either foam rolling or foam rolling plus dynamic stretches for several weeks. Researchers wi…
Phase: NA • Sponsor: University of Lahore • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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New wrap may shield nerves during second elbow surgery
Symptom relief OngoingThis study looks at whether a special nerve wrap can help people who need a second surgery for cubital tunnel syndrome, a condition where a nerve in the elbow gets compressed. Twenty adults with ongoing pain or numbness after their first surgery will receive the nerve protector d…
Phase: NA • Sponsor: Axogen Corporation • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Can a posture device replace surgery for cubital tunnel syndrome?
Symptom relief TerminatedThis study tests whether the UpRight Go posture trainer, a wearable device that vibrates when you slouch, can reduce pain, numbness, and weakness in people with cubital tunnel syndrome who haven't had surgery. Researchers at Yale University plan to enroll 40 adults and track symp…
Phase: NA • Sponsor: Yale University • Aim: Symptom relief
Last updated Jun 26, 2026 17:38 UTC
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Flat feet may be tied to a common cause of hip pain, study suggests
Knowledge-focused OngoingThis study looks at whether people with flat feet (pes planus) are more likely to have piriformis syndrome, a condition that causes pain in the hip and lower back. Researchers will compare foot posture and pain in adults aged 18-65 who have piriformis syndrome with those who do n…
Sponsor: Kahramanmaras Sutcu Imam University • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC
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Sugar water injection may reveal hidden strength in drop foot patients
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at whether a simple injection of sugar water (D5W) can reliably bring out a hidden sign of muscle strength in people with drop foot. Researchers will inject the fluid under the skin and check muscle strength before and after. The goal is to see if this test can h…
Phase: NA • Sponsor: US Neuropathy Centers • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Leg stretch may alter nerve pain sensitivity, tiny study hints
Knowledge-focused ENROLLING_BY_INVITATIONThis study tests whether a specific leg stretching technique, called sciatic nerve mobilization, can change how sensitive the nerves in your lower leg are to pressure pain. 34 healthy university students will either receive the stretch or no treatment. Researchers will measure pa…
Phase: NA • Sponsor: Fenerbahce University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Decision aids may ease patient uncertainty in hand surgery
Knowledge-focused TerminatedThis study tests whether giving patients with hand problems like carpal tunnel syndrome or trigger finger a decision aid—a booklet with clear information about their condition and treatment options—helps them feel more satisfied and less conflicted about their choices. About 126 …
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC