Hemorrhagic stroke

This study tests an experimental drug, NPI-001 (AT-001), in people with hereditary cystatin C amyloid angiopathy (HCCAA), a rare genetic condition that causes repeated brain bleeding and stroke. The trial includes about 15 participants aged 12 and older who carry the specific L68…

This study tests whether the drug deferiprone can safely lower iron levels in the brain after a bleeding aneurysm. About 66 adults who had a ruptured aneurysm will receive either deferiprone or a placebo for 14 days. Researchers will measure iron in spinal fluid, brain MRI scans,…

This study tests whether a procedure called spinal cord stimulation can reduce blood vessel spasms that often occur after a brain aneurysm rupture. Participants have already had standard treatment for their aneurysm and will receive either real or sham stimulation. The goal is to…

This trial investigates whether using a device to continuously measure pressure inside the brain's fluid-filled spaces can improve outcomes for people who have had a bleeding stroke from a ruptured aneurysm. About 372 adults with moderate to severe bleeding will be randomly assig…

This study tests whether naloxegol, a drug that blocks opioid effects in the gut, can prevent constipation and pneumonia in brain-injured patients in the ICU. These patients often receive opioids for sedation, which can slow digestion and lead to serious complications. The trial …

This study tests a wireless device that stimulates the vagus nerve during rehabilitation exercises to help people who have had a stroke recover arm and hand function. The approach, called targeted plasticity therapy, aims to enhance the brain's ability to rewire itself. The trial…

This study tests a blood-filtering device called DELP in people who have had a hemorrhagic stroke (bleeding in the brain). The filter removes fats and other substances from the blood to reduce brain swelling and damage. About 356 adults aged 18-80 with mild to moderate stroke sym…

This study compares two ways to help stroke survivors control their blood pressure using telehealth. About 86 participants will receive either enhanced remote monitoring or standard care. The goal is to see which approach better helps people reach a safe blood pressure target and…

This pilot study tests whether a blend of in-person therapy and home-based digital rehab (video calls and apps) works as well as traditional full in-person rehab for people recovering from stroke, brain bleeding, or head injury. Thirty participants will each try both approaches i…

This study tests an experimental drug called MW189 in 120 adults who have had a brain bleed (intracerebral hemorrhage). The goal is to see if the drug is safe and can reduce brain swelling. Participants receive the drug within 24 hours of their stroke and are monitored for side e…

This study tests whether giving stroke patients extra tests—like checking for hidden heart problems, artery stiffness, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people in Stockholm will get this expanded check-up and a personal…

This study tests whether adding spironolactone to standard blood pressure treatment helps lower blood pressure more effectively in people who have had a stroke. About 160 adults who had a bleeding or clot-caused stroke are taking spironolactone or continuing their usual care. Res…

This early study tests whether beta-sitosterol, a plant-based supplement, can safely help people recover from a severe type of stroke called subarachnoid hemorrhage. Forty adults who have had this stroke will take the supplement for six months. The study will check for side effec…

This study follows 160 people who have or will get a CODMAN CERTAS Plus valve, a device implanted in the brain to drain extra fluid. The main goal is to see if the valve is placed correctly and works without problems 30 days after surgery. Participants include children and adults…

This study tests whether the blood thinner edoxaban can prevent strokes in people with atrial fibrillation (an irregular heartbeat) who have already survived a brain bleed. About 948 participants will receive either edoxaban or non-anticoagulant therapy (like aspirin or no blood …

This phase 3 trial tests whether a drug called recombinant factor VIIa (rFVIIa), given within 2 hours of a bleeding stroke, can limit brain damage and improve recovery. About 860 adults aged 18–80 with spontaneous intracerebral hemorrhage are enrolled. The study compares rFVIIa t…

This pilot study tests whether a ketogenic diet—a high-fat, low-carbohydrate diet—is safe and feasible for children in the pediatric ICU with acute brain injuries like stroke or traumatic brain injury. The idea is that after injury, the brain may struggle to use sugar for energy,…

This study looks at whether giving platelets (cells that help blood clot) to people with severe traumatic brain injuries who are on antiplatelet medications (blood thinners) can improve clotting and stop bleeding in the brain. About 225 adults with certain types of head bleeds wi…

This study tests whether a nerve block in the neck can increase blood flow to the brain in people who develop narrowed blood vessels after a bleeding stroke. Ten adults in the ICU will receive the block, and researchers will measure changes in blood flow and neurological function…

This study tests whether a combination of stereotactic (computer-guided) surgery and a clot-dissolving drug can help people recover from a deep brain hemorrhage. The trial enrolls 380 adults with small-to-moderate bleeds in the basal ganglia who have significant disability. The g…

This study planned to test whether donated umbilical cord blood could help adults with stroke or spinal cord injury. However, the trial was withdrawn before enrolling any participants, so no data or results are available.

This study tests whether a video-based telehealth program, including an iPad and remote blood pressure monitoring, can help stroke survivors better control their blood pressure after leaving the hospital. The program also aims to reduce racial disparities in post-stroke care. Abo…

This study tests whether a kidney ultrasound can help doctors detect acute kidney injury early in people who have had a hemorrhagic stroke. Researchers will measure blood flow in the kidneys of 45 adult patients and see if it predicts kidney problems. The goal is to catch kidney …

This study compares how well AI and radiologists diagnose brain diseases using CT and MRI scans. Over 30,000 patients will be included, and the AI has been trained on more than 100,000 previous scans. The goal is to see if AI can match human experts and whether combining AI with …

This study tests a new program called PA-ChatS that helps people increase physical activity in the first 6 weeks after a stroke. Participants wear a Fitbit to track steps and have weekly phone meetings with an occupational therapist for 6 weeks. The study includes 25 stroke survi…

This study follows adults hospitalized with hemorrhagic stroke to see how procalcitonin, a blood marker, changes over the first few days. The goal is to determine if procalcitonin can help doctors tell whether a fever is due to a bacterial infection or another cause, potentially …

This study tests whether a new scoring system, called PRO-ICH, can accurately predict how well people will recover after a spontaneous brain hemorrhage. Researchers will also check if adding certain blood markers improves the score's accuracy. The goal is to give doctors a reliab…

This observational study looks at how inserting a central venous catheter into the neck affects pressure inside the skull in patients with acute brain injury. Researchers will monitor brain pressure, blood flow, and oxygen levels during and after the procedure in about 120 ICU pa…

This study follows 250 people who had a type of stroke called intracerebral hemorrhage (ICH) to understand why some experience progressive cognitive decline. Participants undergo advanced brain scans and tests of thinking and movement at 12–24 months after their stroke, with foll…

This study follows 350 people who survived a brain bleed (intracerebral hemorrhage) and were part of earlier trials. Researchers will test memory, thinking, and movement skills over time, and collect blood samples to look for signs of ongoing inflammation. The goal is to see if s…

This study looks at 1,000 patients on blood thinners who had a minor head injury and a normal first CT scan. Researchers want to see if a second CT scan 24 hours later finds any delayed brain bleeding. The goal is to understand whether the extra scan is needed and how often it le…

This study looks for tiny plastic particles in brain tissue removed during surgery for spontaneous bleeding. Researchers will test if these plastics are linked to more inflammation and worse recovery in 150 patients. No new treatment is given; the goal is to understand if environ…

This study looks at whether having a rehabilitation doctor see stroke patients early in their hospital stay can shorten how long they stay and reduce the chance of coming back. Researchers are tracking 3,000 stroke patients to see if this coordinated care approach improves recove…

This study is creating a statewide collection of blood samples and medical information from people with various brain blood vessel diseases, such as stroke and dementia. The goal is to build a resource that scientists can use in future research to better understand and potentiall…

This study follows over 2,400 adults in Korea who have had their first stroke. Researchers will track their recovery, daily activities, and quality of life for 10 years. The goal is to learn what factors help or hinder long-term recovery after a stroke.

This study looks at two different blood pressure goals for adults who just had brain tumor surgery. Half the patients will have a target of less than 160 mmHg, the other half less than 140 mmHg. Researchers want to see which group leaves the hospital sooner, without more bleeding…

This study was designed to see how changing the head position affects pressure inside the skull in people who had a brain bleed from a burst aneurysm. It planned to monitor adults with a pressure monitor already in place. However, the study was withdrawn before enrolling anyone, …

This study looks at how social factors like income, education, and lifestyle might influence the risk of a brain aneurysm bursting. Researchers will analyze data from 1,800 patients using artificial intelligence to find patterns. The goal is to improve risk prediction and help pr…

This study looks at whether stopping overnight neurological checks in stroke patients can help prevent delirium, a common and serious complication. Researchers will compare patients who continue standard overnight checks with those who have them stopped, measuring rates of deliri…

This study looks at whether a computer-guided breathing machine (ventilator) protocol can help patients with serious brain injuries. The goal is to use low air volumes to protect the lungs while keeping carbon dioxide levels normal to protect the brain. About 728 adults on ventil…

This study was designed to track hidden symptoms like memory or concentration problems in people recovering from a brain bleed (subarachnoid hemorrhage). Researchers planned to follow patients for one year using questionnaires to see how these symptoms affected daily life and ret…

This study follows 1,000 stroke survivors and their caregivers to understand how social factors and discrimination affect recovery. Researchers will survey participants over time to measure outcomes like quality of life and caregiver strain. The goal is to identify why some group…

This study looks at spinal fluid and blood from 150 adults who had bleeding from a brain aneurysm. Researchers use a special laser technique to find proteins and genes that might predict when dangerous blood vessel spasms will happen. The goal is to better understand these marker…

This study follows 1000 adults who have had a stroke to better understand how the brain recovers. Researchers use brain scans, electrical signals, and physical tests to find patterns linked to recovery. The goal is to improve predictions and treatments for stroke survivors.

This study followed 602 people who had a stroke to see how many later had seizures. Researchers looked at blood tests, brain scans, and EEG recordings to find clues that might predict who is at risk. The goal is to better understand why some stroke survivors develop epilepsy.

This study follows about 300 children who had seizures shortly after birth to see if their genes influence whether they develop epilepsy later in childhood. Researchers will combine genetic information with brain scans and EEG results to create a risk score. No new treatments are…

This study uses MRI scans to check for hidden brain aneurysms in close relatives (parents, siblings, or children) of people who have had a bleeding aneurysm. It aims to find who is at higher risk and how lifestyle factors like smoking or high blood pressure affect that risk. Abou…

This study tests a new computer-based visual training task for people who have lost part of their vision due to a stroke. Participants watch moving patterns on a screen and learn to detect motion direction, with the goal of improving visual abilities. The study first checks if th…

This study follows 400 people who had a brain aneurysm rupture and were treated with a procedure called embolization. The goal is to learn about their long-term recovery and whether the aneurysm can come back. Researchers will track neurological outcomes using a standard scale. T…

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study looks at brain activity and heart patterns in people who have had a stroke and compares them to healthy adults. Researchers use special head sensors and heart monitors to measure differences. The goal is to better understand how stroke changes the brain and heart. No t…

This study looks at how the brain's visual system changes in the year after a stroke that damages the vision center. Researchers will measure vision and brain structure over time, and give participants a home-based computer training program that asks them to detect moving dots. T…

This study tested a new device that measures blood flow, pressure, and temperature inside the brain, while also draining fluid. It was designed for patients with serious brain injuries who already need standard monitoring. Only one person took part, and the goal was to see if the…

This study looks at whether a structured care plan can help people who had a brain hemorrhage (intracerebral hemorrhage) start moving earlier and more safely. About 198 participants will be guided through a step-by-step mobility program while their heart, breathing, and brain sta…