Hemiplegia

This trial compares two rehabilitation approaches—neurodevelopmental technique (NDT) and mirror therapy—to see which better improves coordination, leg function, and walking ability in people recovering from a sub-acute stroke. Forty adults aged 45 to 65 with hemiplegia (weakness …

This study compares two rehabilitation techniques—mirror therapy and modified constraint-induced movement therapy—to see which better improves arm function in people who had a stroke. Sixteen participants with hemiplegia (weakness on one side) will be randomly assigned to one of …

This study tests whether combining task-oriented training with functional electrical stimulation (FES) can improve balance and ankle strength in children aged 6-9 with hemiparesis (weakness on one side). Thirty-six children will participate in a structured exercise program three …

This early study tests a device that reads brain signals and stimulates the spinal cord to help people with chronic stroke move their arms and legs again. Only 3 participants will be implanted with electrodes on the brain and spine. The main goal is to check safety, but researche…

This study tests whether freezing specific nerves (cryoneurolysis) can reduce shoulder pain and improve movement in people with spasticity from conditions like stroke or brain injury. Fifty adults will either receive one session of nerve freezing or one session of Botox injection…

This study tests a surgery that moves a nerve from the neck to help people with arm weakness after a stroke. It is for those whose arm has not improved with rehab. The goal is to see if the surgery can improve arm movement and control.

This study tests a new device called SSMD to help people with arm weakness after a stroke or traumatic brain injury. About 150 adults will use the device in supervised sessions over 5-6 weeks. The goal is to see if it improves arm movement better than standard electrical stimulat…

This study tests whether adding a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to standard physical therapy can improve arm and hand function in people who have had a first ischemic stroke. Sixty-six adults aged 18 to 80 with…

This study tests whether pairing electrical stimulation of the brain's hand area with stimulation of a wrist nerve can improve hand and arm function in adults with hemiplegic cerebral palsy (hCP). Researchers will measure changes in muscle responses and dexterity tasks like movin…

This clinical trial investigates whether photobiomodulation, a non-invasive light therapy, can reduce muscle spasticity in adults who have had a stroke. About 42 participants with spastic hemiparesis will receive either active light therapy or a placebo treatment on their calf mu…

This study tests whether extracorporeal shock wave therapy (ESWT) can reduce spasticity—stiff, tight muscles—in the wrists of people who had a stroke at least six months ago. Researchers will give 32 participants either ESWT plus standard rehab or just standard rehab. They will u…

This study tests whether adding a mild brain stimulation technique (tDCS) to a standard arm therapy (constraint-induced therapy) helps people who had a stroke more than therapy alone. Forty adults with chronic stroke and mild-to-moderate arm weakness will be randomly assigned to …

This study tests a new, smarter electrical stimulation system to help people who have had a stroke walk better. The system uses a computer to adjust stimulation in real time, aiming to correct footdrop (when the foot drags). About 20 participants will compare this new system to a…

This study tests a wearable neuroprosthesis that uses mild electrical stimulation to help stroke survivors open their hand. Two participants will use the device at home for one year to see if it improves daily activities and quality of life. The goal is to understand how well the…

This study tests whether repetitive transcranial magnetic stimulation (rTMS) can improve heart rate variability and quality of life in people who have had a stroke. 44 participants will receive either real or sham rTMS for 4 weeks. The goal is to see if this brain stimulation can…

This study compares a home-based telerehabilitation program (Tele-CPASS) to standard in-person therapy for improving arm and hand function after a stroke. Forty-two recent stroke survivors with arm weakness will be randomly assigned to receive 20 hours of either remote or in-pers…

This study tests whether adding a wearable vibratory device to standard physiotherapy helps improve arm function in people with hemiplegia (paralysis on one side) after a stroke. Thirty adults who had a stroke 3 to 6 months ago will be split into two groups: one gets usual therap…

This study tests a special hand device that helps people who had a stroke and cannot open their hand to grab things. The device is designed to let users control it themselves to pick up, move, and release objects like a glass or spoon. Researchers will compare how well 30 partici…

This study tests whether combining mirror therapy with a soft robotic glove can improve hand function in people who have had a stroke and have weakness on one side. 104 participants will be randomly assigned to receive either standard rehab, mirror therapy alone, the robotic glov…

This study is testing a device called SynPhNe that stroke survivors can use at home to retrain their hand function. The goal is to see if it improves hand movement compared to standard care alone. The study will include 40 adults who had a stroke at least 6 months ago and have mo…

This study tests whether a new AI-powered algorithm can improve how people with chronic arm weakness from a stroke control a robotic arm brace. Participants will use both the standard control method and the experimental algorithm while moving blocks. The goal is to see if the new…

This study is testing a device called MyHand 2 that helps people who have had a stroke use their affected hand better. The device is worn on the hand and assists with movement. Researchers want to see if it is easy to use and helpful for daily tasks. The study involves 60 adults …

This study looks at whether walking on a treadmill can improve how stroke survivors move. Many people who have had a stroke walk unevenly and have different skin temperatures on their affected side. The researchers will measure changes in walking speed, endurance, and body heat p…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve breathing muscle strength in people who had a stroke 1-3 years ago. Researchers will measure lung function in 50 participants before and after treatment. If successful, TAVNS coul…

This study compares two modern therapies—mirror therapy and virtual reality (VR)—to see which better improves arm function in people with hemiplegia after a stroke. Forty-two participants aged 18-75, who had a stroke 6-12 months ago, will be randomly assigned to one session of ei…

This study tests whether psilocybin, a psychedelic substance, is safe for people who had a stroke at least a year ago. Researchers will monitor blood pressure and other vital signs in 20 participants. The goal is to see if psilocybin can help with lingering symptoms like weakness…

This study tests whether wearable robotic gloves and virtual reality exercises can improve hand and arm function in people who have had a stroke. About 42 adults aged 30-60 with lasting hand weakness will be randomly assigned to standard therapy, therapy with a robotic glove, or …

This study looks at whether adding virtual reality therapy to standard rehabilitation and action observation therapy can improve arm and hand function in people who had a stroke 6 weeks to 6 months ago. About 38 adults will be split into two groups: one gets standard care plus ac…

This study tests whether a suprascapular nerve block (a numbing injection) plus physical therapy can improve shoulder joint awareness and reduce pain in stroke survivors with hemiplegic shoulder pain. Fourteen participants will be randomly assigned to receive either the nerve blo…

This study tests whether kinesio taping (a special elastic tape) or PNF (a type of movement therapy) better helps stroke survivors with hand weakness. Fifty-four adults who had a stroke 6 to 24 months ago will receive one or both treatments 3 days a week for 8 weeks. Researchers …

This study looks at whether botulinum toxin type A injections can improve hand and leg function and quality of life in 30 children aged 8 to 17 with spastic hemiparetic cerebral palsy. Participants receive one injection and are followed for 12 weeks. The goal is to see if this tr…

This study tests whether combining a mild nerve stimulation (taVNS) with intensive hand therapy (CIMT) can improve arm function in infants aged 8-24 months who have one-sided weakness due to brain injury. Ten infants will receive 40 hours of therapy over two weeks, and researcher…

This study tests a non-invasive brain stimulation technique called iTBS to see if it can improve balance and leg movement in people who had a stroke more than six months ago. Researchers will measure changes in walking and brain activity. The goal is to find a safe, practical way…

This study tests whether adding a mild electrical stimulation to the skin of the affected hand (called SAES) can improve hand function in children aged 6-18 with hemiparesis (one-sided weakness) due to cerebral palsy or stroke. 34 participants will be randomly assigned to receive…

This study tests whether a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) can improve arm and leg movement in people who had a stroke more than six months ago. 48 participants will receive either real or sham stimulation over 15 sessio…

After a stroke, many people lose the ability to open their affected hand. This study tests three different non-invasive brain stimulation methods combined with hand therapy to see which works best. Researchers will enroll 63 adults who had a stroke 6 to 24 months ago and compare …

This study tests whether adding mild electrical pulses to leg muscles during stationary cycling helps people with stroke-related leg weakness improve their heart fitness and walking ability. Thirty adults who had a stroke within the past year will cycle three times a week for eig…

This study tests a new non-invasive brain stimulation technique called mirror-PAS, which combines visual and motor signals to promote brain plasticity. Researchers will compare it to standard brain stimulation in 36 people with stroke-related arm weakness or phantom limb pain. Th…

This study compares three different robotic exoskeletons to see which one helps stroke survivors walk better. Researchers will enroll 96 people who had a stroke 3 to 8 months ago and have weakness on one side. Participants will use the devices during gait training, and the goal i…

This study uses a special robot called IntelliArm to measure how arm stiffness, spasticity, and movement change during recovery from a first stroke. Researchers will track 56 people who had a stroke less than a month ago, measuring their arm function with standard tests and robot…

This study looks at whether placebos—given openly or hidden—can change brain activity and improve movement in people who had a stroke at least six months ago. Researchers will use brain scans and motor tests to measure effects. The goal is to understand how placebos work in the b…

This study tests whether gentle muscle vibrations can help the brain form new connections after a stroke or traumatic brain injury. Researchers will measure brain and spinal cord activity in 56 participants before, during, and after a 5-week vibration treatment. The goal is to un…

This study is looking at whether the brains and spinal cords of adults with cerebral palsy shrink or change over time, which might explain why some people lose function as they age. Researchers will collect and compare past and new MRI scans from 30 adults with CP across the U.S.…

This study aims to better understand the link between motor (movement) and cognitive (thinking) problems in people with brain damage from conditions like cerebral palsy or stroke. Researchers will assess 400 participants aged 3 to 90 using robotic tools and standard tests. The go…

This study is working to create better methods for evaluating how children with and without stroke or cerebral palsy use their arms and hands. Researchers will observe 80 children, including those with perinatal stroke and typically developing infants, using video and play-based …

This study looks at how a routine exercise program can help the brain rewire itself after a stroke. Researchers will measure changes in genes and proteins linked to brain repair in 48 stroke survivors with weakness on one side. The goal is to understand the biological effects of …

This study reviews medical records of 34 hemiplegic patients who received botulinum toxin injections for muscle spasticity between 2017 and 2020. Researchers will analyze which muscles were injected, dosages used, and how spasticity and function changed over time. No new treatmen…

This study uses fMRI to look at brain and spinal cord activity in people who have had a stroke and have weakness on one side. Participants will perform a simple shoulder movement while being scanned. The goal is to understand which neural pathways are used for movement after a st…