Helicobacter pylori infectious disease

This study tested different combinations of the acid-blocker tegoprazan with antibiotics to treat H. pylori, a common stomach infection. 640 adults who had never been treated before received one of several drug regimens for 14 days. The goal was to see which combination worked be…

This completed study tested whether a new drug called keverprazan, combined with the antibiotic amoxicillin, can effectively treat a first-time H. pylori infection in adults. 264 participants took either keverprazan or esomeprazole (a standard acid reducer) plus amoxicillin for 1…

This study tested a two-drug combination—tegoprazan (a stomach acid blocker) and amoxicillin (an antibiotic)—to treat H. pylori infection, a common stomach bug that can cause ulcers. The trial enrolled 50 adults who had not been treated for H. pylori before. The goal was to see i…

This study tested different doses of the antibiotics minocycline and metronidazole, combined with bismuth and a stomach acid blocker, to treat Helicobacter pylori infections that didn't clear with previous treatments. 480 adults who had failed earlier therapy were randomly assign…

This study looked at 121 people with heart disease who were getting a stent. Researchers checked if they also had a silent H. pylori stomach infection and whether treating that infection reduced stomach symptoms or bleeding. The goal was to see if eradicating the bug helps patien…

This study tested two different drug combinations to treat Helicobacter pylori, a stomach infection that can cause ulcers. About 400 adults took either a two-drug regimen (tegoprazan and amoxicillin) or a four-drug regimen (including bismuth and furazolidone). The goal was to see…

This study tested whether a two-drug combination (vonoprazan plus either amoxicillin or doxycycline) works as well as the standard four-drug bismuth quadruple therapy for eradicating H. pylori infection. 579 adults with H. pylori took one of three 14-day treatments. Researchers m…

This study looked at how the antibiotic cefiderocol works in hospitalized infants under 3 months old with suspected or confirmed gram-negative bacterial infections. Researchers measured drug levels in the blood and checked for side effects in 30 babies. The goal was to find the r…

This study tested the safety and how the body processes the antibiotic cefiderocol in hospitalized children aged 3 months to 18 years with serious bacterial infections. The goal was to see if the drug is safe and how it works in the body. 53 children participated, and the study i…

This study tested a 14-day treatment using two drugs (vonoprazan and amoxicillin) against a more complex seven-then-seven-day regimen for H. pylori infection in 337 adults in Taiwan. The goal was to see if the simpler dual therapy works just as well, with fewer side effects and e…

This study tested whether adding a traditional Chinese herbal formula (Banxiaxiexin decoction) to standard antibiotics can better treat H. pylori infection and related indigestion. 104 adults with both conditions took either the herbal combo or standard therapy for 14 days. The m…

This study tested whether a yogurt containing LG21 probiotics can clear H. pylori infection in children aged 4-6. 140 kids were split into two groups: one ate the yogurt daily for 12 weeks, the other got no treatment. The main goal was to see if the yogurt could turn a positive s…

This study tested a new antibiotic called MK-7655A in 115 children from birth to 18 years old who had serious bacterial infections. The goal was to see if the drug is safe and works better than standard treatments. Children were randomly assigned to receive either the new drug or…

This study tested whether a simpler two-drug treatment (tegoprazan and amoxicillin) works better than the standard four-drug therapy for eradicating H. pylori, a bacteria that can cause stomach ulcers. 370 adults with H. pylori infection were randomly assigned to one of the two t…

This completed study in Laos tested over 1,200 adults for H. pylori, a stomach bacteria linked to cancer. Those infected received a 14-day course of antibiotics and acid-reducing medication. The study also screened high-risk participants for early signs of stomach cancer. The goa…

This study looked at 508 adults with H. pylori infection to see if a 7-day triple therapy (vonoprazan, amoxicillin, tetracycline) works as well as a 14-day dual therapy (vonoprazan, amoxicillin). The goal was to compare how often the infection is cleared and how many side effects…

This study tested two different 14-day drug combinations to treat Helicobacter pylori, a bacteria that causes stomach inflammation and ulcers. Over 750 adults were randomly assigned to either a triple therapy (omeprazole, amoxicillin, clarithromycin) or a quadruple therapy (omepr…

This study tested whether a new triple therapy containing DWP14012 is as good as the standard treatment for eradicating H. pylori, a bacteria that can cause stomach ulcers. 461 adults with confirmed H. pylori infection took part. The main goal was to see if the infection was gone…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested two different drug combinations in 782 people with H. pylori infection that was resistant to the antibiotic clarithromycin. One group received a triple therapy with a proton pump inhibitor, amoxicillin, and metronidazole, while the other received a quadruple the…

This study tested whether a three-drug combination containing rifabutin can wipe out Helicobacter pylori infections that didn't respond to earlier treatments. 360 adults who had failed prior therapy were randomly assigned to one of three regimens. The goal was to see which approa…

This study looked at whether treating Helicobacter pylori (a common stomach infection) with antibiotics can raise platelet counts in people with immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding and bruising. Researchers enrol…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study compared two methods for diagnosing H. pylori infection: the rapid urease test (a simple, cheap test done during endoscopy) and a newer molecular test (PCR) that can also detect antibiotic resistance. Researchers enrolled 100 adults who needed an endoscopy. The goal wa…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested whether a probiotic called Bifidobacterium breve PRL2020 could reduce stomach issues like diarrhea in 121 children aged 3-12 who were taking amoxicillin antibiotics. The children took the probiotic alongside their antibiotic treatment. The goal was to see if it …

This study looked at 335 adults hospitalized with bacterial infections to see if taking NSAIDs (like ibuprofen) before admission made their infections more severe. Researchers compared those with complicated infections (abscesses, needing surgery) to those with simpler infections…

This study looked at health records from over 5,000 adults to see if having an H. pylori stomach infection is linked to metabolic syndrome—a cluster of conditions like high blood sugar, high blood pressure, and excess belly fat. Researchers compared people with and without the in…

This study looked at 7,227 patients in Nanjing to understand how resistant the H. pylori bacteria is to common antibiotics. The goal was to find out which antibiotics still work best and to help doctors choose the right treatment for each patient. No new treatments were tested; i…

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

This study looked at 42 adults with both H. pylori infection and small intestinal bacterial overgrowth (SIBO). Researchers used advanced DNA and chemical tests on stool samples to map the types of gut bacteria and their byproducts. The goal was to better understand how these two …

This study looked at 100 adults with H. pylori infection to find out which antibiotics the bacteria are resistant to and which harmful genes they carry. Researchers took stomach biopsies during endoscopy to test the bacteria and also asked about diet and medication use. The goal …

This early-phase study tested a single dose of the antibiotic omadacycline (Nuzyra) in 23 children aged 8 to 17 who were hospitalized with bacterial infections. Researchers measured how the drug moved through the body and checked for side effects. The goal was to gather safety an…

This study looked at whether antibiotics for H. pylori (a stomach infection) change the natural bacteria in the vagina. Researchers followed 73 women getting treatment and 10 healthy women. They collected vaginal samples before and after treatment to see if the bacteria mix shift…

This study looked back at medical records of 3000 people treated for H. pylori infection to see how often treatment actually works outside of controlled trials. Researchers collected data on which treatments were used and what factors, like antibiotic resistance or patient habits…

This study tested a new imaging technique using a radioactive tracer called 11C-trimethoprim to see how it spreads in the bodies of 16 adults with suspected bacterial infections. Participants had PET/CT scans to track the tracer over time. The goal was to learn how the tracer beh…

This study looked at how a new drug called linaprazan glurate interacts with common antibiotics (clarithromycin, amoxicillin) and bismuth in 56 adults. Some participants were healthy and H. pylori-negative, while others had H. pylori infection. The goal was to measure drug levels…

This study looked at 300 people to see if a common stomach infection, H. pylori, is linked to unhealthy blood fat levels that can lead to heart disease. Researchers measured triglycerides and 'good' cholesterol to calculate a heart risk score. The goal is to understand if treatin…

This study looked at whether a specific gene (TLR9) influences how children's bodies react to H. pylori, a bacteria that can cause stomach pain and inflammation. Researchers compared 50 infected children with 50 uninfected children, all aged 1 to 18, using endoscopy and genetic t…

This study compared a generic vonoprazan 20 mg tablet to the brand-name Voquezna in 28 healthy adults. Participants took a single dose of each under fasting conditions to see if the generic releases the same amount of drug into the bloodstream. The goal was to check bioequivalenc…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study tested over 1,000 people in Bhutan for H. pylori, a stomach infection that can lead to stomach cancer. Researchers measured infection rates and stomach damage to understand the problem and plan a national prevention program. Participants were from rural villages, and t…

This study tested special wearable pumps (elastomeric pumps) to give antibiotics through a drip to hospital patients. Nine adults with bacterial infections took part to see if the pumps are safe, easy to use, and could save time and money compared to traditional methods. The goal…

This study looked back at medical records of 1,730 adults with H. pylori infection who received bismuth-containing quadruple therapy as their first treatment. Researchers compared how well different drug combinations worked and what side effects occurred. The goal was to identify…