New hope for stubborn stomach bug: rifabutin combo shows promise

NCT ID NCT05874544

Completed Disease control Sponsor: Shanghai Jiao Tong University School of Medicine Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 32 times

Summary

This study tested whether a three-drug combination containing rifabutin works better than other treatments for people whose H. pylori infection did not clear with earlier antibiotics. 360 adults who had failed prior treatment took one of three therapies. The main goal was to see which treatment cleared the infection most often, measured by a breath test six weeks later. Side effects were also tracked.

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Contacts and locations

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Locations

Renji Hospital, School of Medicine, Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, 200127, China
Shanghai Songjiang District Central Hospital

Shanghai, Shanghai Municipality, China
The Second Affiliated Hospital of Zhejiang University school of Medicine

Hangzhou, Zhejiang, China

Conditions

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HELICOBACTER PYLORI INFECTION