Helicobacter pylori infectious disease

This trial compares a 14-day course of vonoprazan plus minocycline against two other dual therapies (vonoprazan with amoxicillin or tetracycline) for eradicating Helicobacter pylori, a common stomach infection linked to ulcers and cancer. About 492 adults who have never been trea…

This trial compares two ways to eradicate H. pylori, a common stomach infection linked to ulcers and stomach cancer. One group receives a 10-day course of a high-dose acid blocker plus one antibiotic, while the other gets the standard 14-day four-drug regimen. The goal is to see …

This trial compares two 14-day antibiotic combinations for treating Helicobacter pylori, a common stomach bacteria that can cause ulcers and stomach cancer. One combination uses metronidazole, the other uses a similar drug called tinidazole. The study will see if tinidazole is ju…

This study compares a personalized treatment plan for H. pylori infection against the usual standard care in 360 veterans. The personalized approach uses genetic testing and antibiotic sensitivity to choose the best drugs. The goal is to see which method cures more infections wit…

This trial tests whether a dietary supplement called Pylori Duo, which contains probiotics and licorice extract, can reduce gastrointestinal side effects from standard H. pylori treatment and help prevent the infection from coming back. About 140 adults with confirmed H. pylori i…

This trial tests whether a 10-day course of high-dose vonoprazan plus amoxicillin can clear Helicobacter pylori infection as effectively as the standard 14-day regimen. Adults aged 18 to 70 with a current H. pylori infection and no prior treatment are randomly assigned to one of …

This study tests whether a simpler two-drug treatment (vonoprazan plus one antibiotic) works as well as a three-drug treatment (vonoprazan plus two antibiotics) for H. pylori infection. About 150 adults with confirmed H. pylori will take either regimen for 14 days. The main goal …

This Phase 3 trial tests whether a new acid-reducing drug, anaprazole, works better than the standard drug esomeprazole when used with bismuth and two antibiotics to treat H. pylori infection. About 556 adults in China will take either anaprazole or esomeprazole pills twice daily…

This study compares two 14-day treatments for H. pylori, a stomach bacteria that can cause ulcers and cancer. About 90 adults will receive either a levofloxacin-based sequential therapy or a bismuth-based quadruple therapy. The goal is to see which treatment works better and has …

This study tests a new way to treat Helicobacter pylori (H. pylori) infections that didn't get better with the first round of antibiotics. Instead of using a scope to take a stomach sample, doctors will use a stool test to find which antibiotics will work best. About 531 adults w…

This study tests whether a 7-day course of antibiotics chosen by a stool test works as well as a 14-day course for people with stubborn H. pylori infections. About 290 adults who have failed previous treatment will get a stool test to find which drugs their infection resists, the…

This study tests whether a 7-day course of antibiotics, chosen based on a stool test, can clear H. pylori infection as effectively as a standard 14-day course. About 544 adults with a first-time H. pylori infection will provide a stool sample for drug-resistance testing and then …

This study compares a 7-day high-dose vonoprazan-amoxicillin treatment to a standard 14-day regimen for eradicating H. pylori, a common stomach bacteria linked to ulcers and cancer. About 290 adults with confirmed infection will be randomly assigned to one of the two groups. The …

This phase 3 trial will test how well two different triple therapies—one using a standard acid reducer (proton pump inhibitor) and one using a newer drug (vonoprazan)—work to eliminate H. pylori infection. It will also see if adding zinc improves results. The study plans to enrol…

This study will test whether standard treatment to eliminate H. pylori bacteria can improve ongoing stomach and gut symptoms in 100 adults. Participants will receive antibiotics and acid-reducing medication, and their symptoms will be tracked using a questionnaire. The goal is to…

This study tests two ways of taking amoxicillin with tegoprazan to treat H. pylori, a stomach infection that can cause ulcers. About 240 adults will take the same total daily dose of antibiotics, but one group takes it three times a day and the other twice a day. The goal is to s…

This study tests whether adding a traditional Chinese medicine granule (Huazhi Rougan) to standard antibiotics can better treat both H. pylori infection and metabolic-associated fatty liver disease (MASH). About 286 adults with both conditions will receive either the herbal granu…

This study will collect data from 10,000 people undergoing upper endoscopy to build an AI model that predicts the risk of developing stomach or esophageal cancer. Researchers will combine information from endoscopy images, tissue samples, genetics, and gut bacteria. Participants …

This study looks at whether combining a blood test for H. pylori bacteria with a painless stomach ultrasound can predict serious complications from peptic ulcers, like bleeding or a hole in the stomach. Researchers will study 230 adults with stomach symptoms to see if these non-i…

This study will look at 130 people with H. pylori-related gastritis to see if the infection is linked to anxiety, depression, or other psychological symptoms. Researchers will also check whether treating the infection improves mental health. The goal is to better understand the c…

This pilot study will check if simethicone, a medicine used to reduce gas during endoscopy, makes it harder to detect H. pylori bacteria. About 100 adults with a positive H. pylori test will take simethicone or a placebo before their procedure. The goal is to see if the drug lowe…

This study will measure two molecules, called miRNA-155 and miRNA-204, in stomach tissue from 100 children with ongoing belly pain. The goal is to see if these molecules are linked to gastritis (stomach inflammation) and infection with H. pylori bacteria. Researchers will use spe…

This study will check how common Helicobacter pylori infection is in 100 adults with inflammatory bowel disease (Crohn's or colitis) at the Guadeloupe hospital. Researchers will take extra stomach biopsies during routine endoscopy to study the stomach's bacteria. The goal is to s…

This study looks at whether standard antibiotic doses are effective for ICU patients on ECMO (heart-lung support) or kidney dialysis. Researchers will measure drug levels in 40 adults with serious infections. The goal is to see if dosing adjustments are needed to avoid under- or …

This study will survey 300 general practitioners in Upper Egypt to evaluate their knowledge, attitudes, and practices regarding Helicobacter pylori infection. Researchers aim to identify common barriers that prevent proper diagnosis and treatment. The goal is to highlight gaps th…

This observational study will check if having an H. pylori stomach infection is linked to more active lupus in 115 adults. Researchers will use a stool test to detect the bacteria and a standard lupus score to measure disease activity. No treatments are given; the goal is simply …