Epilepsy

This study tests a liquid form of the seizure drug zonisamide in children aged 1 month to 17 years who have partial-onset seizures. The goal is to find the right dose and check for side effects. About 40 children will take the medicine for up to 12 weeks, with a follow-up visit o…

This study looks at the best way to switch children with Dravet or Lennox-Gastaut syndrome from artisanal (non-pharmaceutical) cannabidiol to Epidiolex, an FDA-approved CBD medication. About 25 children aged 2 to 18 will gradually increase their Epidiolex dose while reducing thei…

Researchers are testing whether MRI-guided high-intensity focused ultrasound can safely reduce seizures in adults with generalized epilepsy that does not respond to medication. The procedure uses sound waves to precisely target and ablate a small brain region involved in seizure …

This study tests a device called EASEE® that is implanted under the skin and above the skull to stimulate the brain and reduce seizures in people with drug-resistant focal epilepsy. Two hundred adults will receive the implant, and half will have the stimulation turned on for 6 mo…

This early-stage trial tests a new cell therapy called UX-GIP001 for adults with drug-resistant temporal lobe epilepsy. The treatment involves injecting special brain cells into the seizure area to calm overactive nerves. Only 12 people will take part, and the main goal is to che…

This study tests an oral drug, AV078, in people aged 12 and older with tuberous sclerosis complex (TSC) whose seizures are not controlled by standard medications. Participants are randomly assigned to receive AV078 or a placebo for 12 weeks. The goal is to see if AV078 safely red…

This study tests whether a fluorescent dye called 5-ALA can help surgeons see and remove abnormal brain tissue in people with drug-resistant epilepsy caused by focal cortical dysplasia (FCD). FCD lesions are often hard to distinguish from healthy brain during surgery, making comp…

This study tests a device that reads brain signals and delivers targeted electrical stimulation to reduce seizures in people with epilepsy. The device aims to calm overactive brain areas before a seizure starts. Researchers will monitor safety and track seizure frequency in 40 pa…

This pilot study tests whether MRI-guided high-intensity focused ultrasound (HIFU) can safely and effectively treat drug-resistant focal epilepsy in 13 adults. The procedure uses focused sound waves to heat and destroy small brain lesions causing seizures, without needing open su…

This early study will test a new way to use deep brain stimulation (DBS) in 4 adults with Lennox-Gastaut syndrome, a severe form of epilepsy. The device will automatically adjust stimulation based on whether the person is awake or asleep. Researchers want to see if this personali…

This pilot study tests a new care pathway for people with epilepsy who are starting or switching anti-seizure medication. The program combines remote monitoring software with support from a nurse to help patients manage their treatment and detect side effects or seizure changes e…

This early-phase study tests the drug cenobamate in 10 adults (ages 18–70) in the intensive care unit who are having frequent seizures or a prolonged seizure (status epilepticus). The goal is to see if cenobamate can quickly reach and maintain a target level in the blood, stop se…

This study looks at whether a non-invasive technique called focused ultrasound can safely treat brain lesions that cause seizures in children with drug-resistant epilepsy. About 20 children aged 4-17 will be followed to see if the treatment reduces seizure frequency and severity,…

This study tests a non-invasive brain training technique called neurofeedback for people with drug-resistant epilepsy. Participants learn to change their own brain activity to reduce seizures. The study compares real neurofeedback to a sham (fake) version to see if it truly works…

This early-stage trial tests whether focused ultrasound waves can safely reduce seizures in 20 adults with drug-resistant epilepsy. The procedure uses MRI guidance to precisely target a small brain area involved in seizure spread. Researchers will monitor side effects and seizure…

Researchers are testing whether a minimally invasive electrode placed under the scalp, called subgaleal EEG, can detect seizures as well as the standard approach that places electrodes inside the brain. The study enrolls 15 adults with drug-resistant epilepsy who are already sche…

This study will develop and test artificial intelligence (AI) to automatically classify sleep stages from overnight sleep recordings (polysomnography). The goal is to see if the AI can match or beat expert manual scoring, with the aim of supporting diagnosis of chronic insomnia a…

This study tests a new, more comfortable brain scanner (OPM MEG) that fits directly on the head to locate where seizures start in people with epilepsy. Researchers will compare its accuracy to standard methods in 70 patients aged 6 to 65 who are already scheduled for epilepsy sur…

This study looks at whether measuring a protein called S100B in the blood can help emergency doctors quickly tell if a person's fainting spell was caused by epilepsy or something else, like a heart problem. About 100 adults who come to the ER after losing consciousness will give …

This study tests the Korus smart mattress in 10 healthy adults to see if it can accurately detect body positions (like lying on the stomach) and automatically reposition the person to a safer side-lying position. The goal is to prevent sudden unexpected death in epilepsy (SUDEP) …

Researchers are testing whether a structured educational program based on Kolcaba's Comfort Theory can improve quality of life for adults with epilepsy. The program addresses physical, emotional, social, and environmental comfort needs through planned sessions delivered alongside…

This trial investigates whether a home-based self-management program called HOBSCOTCH can improve thinking, memory, and quality of life in young adults (ages 18–29) and youth (ages 13–17) with epilepsy. Participants attend nine weekly one-on-one coaching sessions by phone or comp…

This study tests a non-invasive technique called temporal interference stimulation to boost deep sleep in people with epilepsy. Researchers will compare 4 nights of real stimulation to 4 nights of sham (fake) stimulation in up to 16 patients. The goal is to see if better sleep ca…

This study tests whether listening to specific music pieces every morning and night for six months can improve sleep and health in children aged 1.5 to 9 years with epilepsy, as well as their parents. Participants are randomly assigned to hear either a specially designed music tr…

This study tests whether taking a daily hot bath (40-42°C for 20 minutes) at home can reduce epileptic seizures in children with CDKL5 deficiency disorder. The trial will include 34 children aged 6 months to 14 years whose seizures are not controlled by medication. Researchers wi…

This study tests whether a non-invasive brain stimulation technique called temporal interference (TI) can reduce abnormal brain activity and improve sleep in adults with drug-resistant temporal lobe epilepsy. Twenty participants will stay in a sleep lab for six nights, receiving …

This study tests a new, non-invasive brain stimulation method called temporal interference (TI) for people with drug-resistant temporal lobe epilepsy. 30 adults will receive 5 days of TI stimulation targeting the hippocampus. The goal is to see if this reduces seizure frequency o…

This study looks at whether adding dog-assisted therapy to standard psychomotor therapy can improve quality of life for adults with hard-to-treat epilepsy. Researchers will enroll 76 participants who will attend 10 sessions. The main goal is to see if their quality of life score …

This small study will test whether a type of therapy called Compassion Focused Therapy, combined with Loving Kindness Meditation, can help children aged 12-17 with epilepsy who feel anxious, stressed, or ashamed about their condition. Participants will attend three online therapy…

This early study tests a new, flexible brain electrode in 5 people having brain surgery for tumors or epilepsy. The electrode is designed to be placed through a small hole in the skull, which may be safer than traditional methods. The main goal is to see if it works well and is s…

This study looks at whether teaching teens with epilepsy about their condition can improve their knowledge, help them take medication as prescribed, and reduce feelings of stigma. About 60 adolescents aged 12-18 will take part. Researchers will measure changes using surveys befor…

This study tests if waking epilepsy patients with an alarm during their hospital stay can trigger seizures sooner. The goal is to see if this approach can shorten the time patients need to stay in the epilepsy monitoring unit. The study will include 75 people aged 14 to 60 who ha…

This study investigates how the brain processes cognitive tasks like memory, attention, and language by recording electrical activity directly from within the brain. Participants are people with drug-resistant epilepsy who already have electrodes implanted for clinical monitoring…

This study will test whether using virtual reality headsets raises the risk of seizures in adolescents and adults with epilepsy. Forty participants will wear a VR headset while their brain activity is recorded with EEG, comparing periods with the display off, on, and with hand co…

This study tests whether temporal interference (TI) stimulation, a non-invasive technique using scalp electrodes, can safely modulate activity in deep brain regions. Researchers will enroll 60 adults with epilepsy who already have implanted electrodes for monitoring. They will de…

This study explores whether a single low-dose ketamine infusion can reduce depressive symptoms in adults with epilepsy who are already undergoing brain monitoring for their seizures. Participants receive one intravenous dose of ketamine while their brain activity is recorded dire…

This study measures specific substances (metabolites) in the breath and blood of people with inherited metabolic disorders, those on a special ketogenic diet for epilepsy, and healthy volunteers. The goal is to see if a simple breath test can reliably track these metabolites, pot…

This early study at Mayo Clinic tests a new implantable device called the Brain Interchange System in up to 8 people with drug-resistant epilepsy. The device records high-speed brain signals and can deliver targeted electrical stimulation to prevent seizures. Unlike current syste…

This study uses brain scans to see how epilepsy changes a brain chemical called adenosine in areas that control breathing and wakefulness. Researchers will compare 50 people with drug-resistant epilepsy to healthy volunteers. The goal is to better understand why some epilepsy pat…

This study investigates how a drug called Cobenfy KarXT, which affects the brain's cholinergic (acetylcholine) system, alters brain activity during memory and thinking tasks. About 30 people with essential tremor or epilepsy who are already scheduled for deep brain stimulation (D…

This study uses thin, flexible electrode arrays placed on the brain to record electrical signals in people with epilepsy who are already undergoing surgery. Researchers aim to better understand how the brain processes sensory information, memory, and language, and how epilepsy af…

This study tests whether a structured educational program led by a specialized epilepsy nurse helps adults with epilepsy better understand and manage their condition. The program, called Epilepsy Enhanced Care, involves a one-on-one session covering epilepsy types, medications, s…

This study looks at how the brain works in 200 children with hard-to-treat epilepsy who are already scheduled for brain monitoring. Researchers will measure brain activity during tasks like learning and decision-making. The goal is to better understand thinking and memory, which …

This study looks at how the brain works when people make decisions. Researchers will work with 30 adult epilepsy patients who already have electrodes in their brains for medical reasons. While patients play a simple decision-making game, the team will track their brain activity, …

This study will use brain electrodes (SEEG) and breathing monitors in 20 adults with drug-resistant epilepsy to map which brain areas control breathing during a challenge. The goal is to understand why some patients experience fatal breathing arrest after seizures (SUDEP). No tre…

This study will collect real-world data from 100 people with drug-resistant epilepsy who receive or are considered for a procedure using the OneRF Ablation System. The system uses radiofrequency energy to target and destroy small areas of brain tissue causing seizures. Researcher…

This early-phase study tests whether the drug Cobenfy KarXT can change brain activity linked to memory in 50 adults with epilepsy who are already scheduled for brain surgery. Participants will take either the drug or a placebo on separate days and perform memory tasks while their…

This early study tests whether a small device can safely collect fluid from the brain during planned surgery for glioma or epilepsy. Six participants will have the device placed temporarily during their operation. The goal is to see if the device works and is safe, not to treat t…

This study looks at whether people with epilepsy digest food and liquids at a normal rate after following standard pre-surgery fasting rules. Researchers will use a quick, painless bedside ultrasound to check the stomach contents of 30 adults with epilepsy before their scheduled …

This study tests a new DNA technology called long-read genome sequencing in 20 children with severe epilepsy whose standard genetic tests came back normal. The goal is to find hidden genetic causes that standard tests miss, which could lead to better treatments and genetic counse…

This study will give 21 people with migraine with aura an infusion of a protein called PACAP-38, or a placebo, to see if it can trigger an aura attack. The goal is to better understand what causes migraine aura, not to test a treatment. Participants will be monitored for 12 hours…

This study aims to find out if the number of seizures a child has when first diagnosed with epilepsy can predict how well their seizures will be controlled in the long run. Researchers will review medical records and interview 100 patients at Assiut University Children's Hospital…

This study explores whether a special MRI technique called CEST can locate the brain area causing seizures in people with drug-resistant epilepsy. Researchers will scan 20 patients before surgery and compare the MRI results with standard methods. If it works, this could reduce th…

This study tests whether a camera can record useful video of the brain during neurosurgery to help surgeons tell healthy tissue from diseased tissue. Researchers will record 50 adult patients undergoing brain surgery for tumors, epilepsy, or other conditions. The goal is to see i…

This study will follow 200 children with epilepsy to find clues—like brain scans or EEG patterns—that show which kids are likely to become resistant to standard seizure medications. The goal is to catch these cases early and consider alternative treatments such as a ketogenic die…

This study tests whether watching a single episode of the medical drama House M.D. can boost knowledge about neurocysticercosis, a parasitic brain infection that can cause epilepsy. Sixty young adults aged 18-35 will be randomly assigned to either watch the episode or not, and th…

This observational study will look at 185 children with epilepsy to find out how many also have ADHD symptoms. Researchers will track changes in ADHD symptoms and quality of life over 12 weeks. The goal is to identify risk factors and understand how ADHD affects epilepsy outcomes…

This study looks at 70 children aged 1 month to 18 years who have neurological disorders like epilepsy, migraine, or stroke. Researchers will use echocardiograms and ECGs to check for hidden heart problems. The goal is to understand if heart issues are common in these children an…

This study will test whether a mobile app called EPIDAY can predict the daily risk of epileptic seizures in 50 adults with focal epilepsy. Participants will use the app to report symptoms and track seizures for three months. The goal is to see if machine learning can turn these r…