Sound waves vs. seizures: new ultrasound treatment tested for epilepsy

NCT ID NCT07591350

Not yet recruiting Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests whether MRI-guided high-intensity focused ultrasound (HIFU) can safely and effectively treat drug-resistant focal epilepsy in 13 adults. The procedure uses focused sound waves to heat and destroy small brain lesions causing seizures, without needing open surgery. Researchers will check if the target temperature is reached and monitor for complications over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MRI-guided high-intensity focused ultrasound (HIFU) thermoablation
What this could lead to: If successful, this could offer a non-surgical option to control seizures in people with drug-resistant epilepsy who cannot have traditional brain surgery.
What could go wrong: This is a very small, early pilot study with only 13 participants, so results may not apply widely. The procedure may not safely reach the target temperature or could cause complications.

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Conditions

The condition(s) this trial relates to.

Drug Resistant Epilepsy epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY

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Other studies related to the condition(s) this trial covers.