Diabetic kidney disease

This study tested whether taking two doses of sodium bicarbonate (baking soda) over 24 hours could reduce uric acid crystals in the urine of adults with type 1 diabetes. Uric acid crystals can harm the kidneys, so lowering them might help prevent diabetic kidney disease. The tria…

This phase 2 trial tested whether adding the experimental drug lorundrostat to standard SGLT2 inhibitor therapy can lower blood pressure in adults with chronic kidney disease and albuminuria (protein in urine). Sixty participants received either lorundrostat or a placebo for four…

This study tested a plant-based tablet called PH3 in 100 adults with diabetic nephropathy (kidney damage from diabetes). The goal was to see if PH3 can safely reduce protein in the urine, a sign of kidney stress, over 24 weeks. Researchers also looked at the best dose to use in f…

This study tested whether a class of diabetes drugs called SGLT2 inhibitors can slow the progression of kidney disease in adolescents with type 1 diabetes. Researchers measured changes in urine protein levels and blood sugar control over 6 months in 86 participants aged 10-18. Th…

This completed study tested whether lotus seed capsules could improve nerve health, blood sugar, and immune function in 60 people with type 2 diabetes and nerve damage. Participants took either lotus seed or placebo capsules for 9 months alongside their regular diabetes treatment…

This study tested whether resveratrol, a natural substance found in grapes and peanuts, could improve blood sugar control and kidney health in 60 teenagers with type 1 diabetes and early kidney damage. Participants took resveratrol tablets twice daily for 6 months. The study meas…

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This study tested whether levocetirizine, an allergy medication, can reduce protein leakage in the urine of people with diabetic kidney disease. The trial enrolled 60 adults aged 40-65 with type 2 diabetes and early kidney damage. Researchers measured changes in albuminuria to se…

This study tested a new drug called CU01-1001 in 240 adults with type 2 diabetes and early kidney damage (albuminuria). Participants took the drug or a placebo for 24 weeks to see if it could reduce protein leakage in urine, a sign of kidney health. The goal is to find a treatmen…

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This study looked at how well the drug Roxadustat works for anemia in people with diabetic kidney disease stages 3-4. 124 participants took the drug for 24 weeks, and researchers measured changes in hemoglobin and iron levels. The goal was to see if the drug can safely raise red …

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve kidney, heart, and pancreas function in teens aged 12-21 with type 2 diabetes and obesity. Researchers measured blood flow to the kidneys, kidney filtering ability, and insulin production b…

This study tested whether canagliflozin, a diabetes drug, can slow kidney decline in 308 Japanese patients with diabetic nephropathy. Participants took either the drug or a placebo daily for about two years. The main goal was to see if fewer people on the drug had a 30% drop in k…

This phase 2 trial tested HRS-7535, a new drug, in 281 adults with type 2 diabetes and diabetic kidney disease. Participants received either the drug or a placebo for 16 weeks. The main goal was to see if HRS-7535 could reduce protein in the urine, a sign of kidney damage, and he…

This study tested a program that helps low-income African Americans with diabetic kidney disease get their basic needs, like food and housing, while also providing lifestyle coaching. Fifty participants received one-on-one sessions and a device to track blood sugar and blood pres…

This study tested whether a probiotic supplement containing two live bacteria strains could help people with diabetic kidney disease. Fifty adults with type 2 diabetes and early-stage kidney problems took either the probiotic or a placebo daily for 6 months. Researchers measured …

This completed study tested whether adding allopurinol (a gout medication) to standard lisinopril treatment could better protect kidneys in people with type 2 diabetes. 80 patients with normal uric acid levels were split into two groups: one received both drugs, the other lisinop…

This completed Phase 2 trial tested QRX-3, a drug that boosts NAD activity in kidney cells to reduce damage and improve function. 127 adults with chronic kidney disease stages 3-5 took part over 12 months. Researchers measured changes in kidney function and protein levels in urin…

This study uses machine learning to tell apart diabetic kidney disease from other kidney diseases in people with type 2 diabetes. Researchers analyzed data from over 2,200 patients across 14 medical centers to build a model that uses routine clinical and lab information. The goal…

This early-phase trial tested a radioactive tracer called Tc-99m-Tilmanocept to see if it can help doctors detect diabetic kidney disease using SPECT/CT scans. The study involved 57 adults with suspected diabetic kidney disease. The goal was to measure how the tracer behaves in t…

This study tested a new wearable patch that collects sweat to measure sodium and creatinine levels, which are important for monitoring kidney health and dehydration. Five adults with kidney disease wore the patch while their sweat was analyzed using a special light-based techniqu…

This study looked at two ways to help people with diabetic nerve pain in their legs: high-intensity laser therapy and moderate aerobic exercise. Sixty adults with symptoms like numbness, tingling, or burning took part. The goal was to see which approach improves leg function and …

This completed study analyzed electronic health records from over 6,500 patients in China who started taking finerenone for chronic kidney disease and type 2 diabetes. Researchers tracked kidney function, potassium levels, and side effects like high potassium. The goal was to see…

This study looked at how the amount of salt in the diet changes the effects of the diabetes drug ertugliflozin on blood pressure and kidney function. Overweight adults with type 2 diabetes followed either a low-salt or high-salt diet while taking the drug or a placebo. The goal w…

This study measured certain inflammatory markers in the saliva and blood of 126 people with type 2 diabetes, some of whom also had kidney disease (diabetic nephropathy). The goal was to see if these markers differ based on gum health. Researchers hope to better understand the lin…

This study tested whether a personalized, home-based exercise program done via video calls could improve muscle function in people with moderate-to-severe chronic kidney disease (CKD) who are not on dialysis. Thirty-two sedentary adults aged 30-75 with CKD took part. They did com…

This study followed nearly 6,000 people with kidney disease from around the world. Researchers collected routine test results like kidney function and protein in urine to better understand how the disease progresses. The goal was to gather information, not to test a new treatment…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This study looked at whether the diabetes drug metformin can be used safely in people with type 2 diabetes who also have kidney disease. Researchers gave increasing doses of metformin to 82 patients with different stages of kidney failure and measured the drug levels in their red…