Cystitis

This study looks at two ways to manage recurrent urinary tract infections (UTIs) in women. One group takes a daily antibiotic called nitrofurantoin. The other group has a minor procedure to burn away tiny spots in the bladder (electrofulguration) and also takes the daily antibiot…

This phase II trial tests whether a 12-week course of higher-dose antibiotics combined with a urinary antiseptic (methenamine hippurate) can better control chronic UTI than standard low-dose antibiotics or antiseptic alone. About 192 adults with daily UTI symptoms for at least 3 …

This study tests whether injecting a substance made from donated amniotic membrane into the bladder can reduce pain and urgency in women with interstitial cystitis (painful bladder syndrome). One hundred women who have not gotten better with other treatments will receive either t…

This study looks at whether a heart procedure called left atrial occlusion can help patients who have both atrial fibrillation (an irregular heartbeat) and radiation cystitis (bladder inflammation from cancer treatment). These patients often take blood thinners to prevent strokes…

This study tests a gene therapy called Neovasculgen in 180 women with painful bladder syndrome and Hunner's lesions. The goal is to reduce scarring from previous treatments and prevent the bladder from shrinking. Participants receive either the drug or a placebo, and doctors chec…

This study tests a gene therapy called Neovasculgen for people with painful bladder syndrome/interstitial cystitis, a condition causing pelvic pain and frequent urination. The treatment is injected into the bladder wall during a procedure. The goal is to reduce pain and prevent t…

This study tests whether giving patients a special nutritional drink (immunonutrition) before bladder removal surgery can reduce complications like infections. About 232 adults having open cystectomy for various bladder conditions will be randomly assigned to receive the drink or…

This study compares two ways to prevent repeat urinary tract infections (UTIs) in women after menopause. One group takes a nightly antibiotic pill for 6 months, while the other uses a vaginal tablet containing a probiotic (Lactobacillus) and a tiny amount of estrogen. The goal is…

This study tests whether moxibustion, a traditional therapy that burns herbs near the skin, can prevent hemorrhagic cystitis (painful bladder inflammation) in 266 patients receiving stem cell transplants. Participants are randomly assigned to receive either standard care or stand…

This study tests whether taking D-mannose, a natural sugar, daily for a year can prevent recurrent urinary tract infections (UTIs) in post-menopausal women aged 55 and older. Researchers will compare D-mannose to a placebo in 90 women who have had multiple UTIs. The goal is to se…

This study tests whether a super-concentrated, freeze-dried aloe vera capsule can safely reduce symptoms of interstitial cystitis, a chronic bladder condition causing pain and frequent urination. About 30 adults with frequent urination and moderate-to-severe pain will receive eit…

This study tests whether a shared decision-making tool can help pharmacists and patients better understand when antibiotics are truly needed for uncomplicated cystitis (bladder infection). About 506 women with symptoms will be enrolled. The goal is to reduce unnecessary antibioti…

This study is testing whether a low-frequency pulsed electromagnetic field (PEMF) device can safely reduce pelvic pain and urinary symptoms in women with Interstitial Cystitis/Bladder Pain Syndrome. About 75 female adults will use the device at home, and researchers will track th…

This study tests whether delivering tiny electrical bursts to a nerve bundle in the lower back can reduce pain in women with bladder pain syndrome. Five women will receive the procedure once and be followed for six months. Researchers will measure pain, bladder symptoms, mood, an…

This study looks at 56 adults with non-muscle-invasive bladder cancer who receive BCG therapy, a standard treatment that often causes painful bladder symptoms. Researchers want to see if giving Blad-Care (a gel that restores the bladder's protective lining) early during BCG treat…

This study looks at whether a single injection of the antibiotic amikacin can effectively treat uncomplicated bladder infections in women visiting the emergency department. Instead of taking pills for several days, participants receive one shot into a muscle or vein. The goal is …

This study tests a brief, 4-session cognitive behavioral therapy (CBT) program for people with urologic chronic pelvic pain syndrome (UCPPS), including interstitial cystitis and chronic prostatitis. The treatment is mostly home-based with minimal therapist contact, teaching skill…

This study looks at whether people with different types of bladder pain respond better to different treatments. About 220 adults with interstitial cystitis/bladder pain syndrome will receive either pelvic floor physical therapy or cognitive-behavioral therapy. The goal is to see …

This study tests a drug called VNX001 for people with Interstitial Cystitis (a painful bladder condition) who have sudden, moderate-to-severe bladder pain. About 50 adults will receive up to 6 doses of the drug directly into the bladder over 14 days. The goal is to see if the dru…

This study tests a single dose of VNX001, a mix of lidocaine and heparin, to quickly reduce moderate to severe bladder pain in people with interstitial cystitis/bladder pain syndrome. About 120 adults with a history of IC/BPS for at least 9 months will receive either VNX001, plac…

This study tests whether adding acupuncture to standard behavioral changes can better relieve bladder pain in women with interstitial cystitis. Thirty-four women who have not had prior treatments will receive either behavioral management alone or behavioral management plus weekly…

This study looks at how hyperbaric oxygen therapy (HBOT) affects symptoms and urine markers in people with chronic radiation cystitis, a bladder condition caused by past radiation treatment. Researchers will collect urine, blood, and tissue samples from 100 participants before, d…

This study aims to find out if chronic pelvic pain conditions like prostatitis and interstitial cystitis can be inherited. Researchers will collect DNA and urine from 500 participants, including family members, to look for genetic links. The goal is to better understand the cause…

This study follows 1,000 adults who have long-term bladder or bowel problems from past cancer radiation and are receiving hyperbaric oxygen therapy (HBOT). Researchers want to learn which patients improve most and when treatment works best. The goal is to better understand how to…

This study looks at whether repeated sessions of hyperbaric oxygen therapy (HBOT) can damage DNA in people who have had radiation for cancer. HBOT is used to help heal tissues damaged by radiation, but it also creates reactive oxygen molecules that might harm DNA. Researchers wil…

This study aims to find genetic factors that may cause interstitial cystitis (also called bladder pain syndrome). Researchers are collecting blood or saliva samples and medical information from 1,000 people with the condition and their family members across North America. No trea…

This study looks at women aged 50 and older who have visible blood in their urine along with a bladder infection. Researchers want to find out if these women really need to undergo invasive tests like cystoscopy and CT scans to check for bladder or kidney cancer. By following 300…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…